Endocan level in serum and lesional skin of psoriasis vulgaris patients

Background: It is proven that severe psoriasis might be associated with an increased mortality rate because of a higher prevalence of metabolic syndrome and cardiovascular disorders. Endocan is a human cell-specific molecule that is expressed by the vascular endothelium. Endothelial dysfunction is widely accepted as being involved in the development of psoriasis, as well as atherosclerosis. Objective: To investigate serum and tissue levels of endocan in psoriatic patients versus nonpsoriatic controls, as it may have a role in the pathogenesis of psoriasis, and to correlate these levels to psoriasis area severity index score, as well as metabolic syndrome. Patients and methods: Quantitative, enzyme-linked immunosorbent assay was performed to measure endocan concentrations in serum and lesional skin samples in 40 psoriasis vulgaris patients versus 40 age-matched and sex-matched nonpsoriatic controls. Results: Endocan levels in sera and skin biopsies were significantly higher in patients (53.65±82.60 and 30.00±7.75 ng/ml, respectively) compared with controls (7.51±5.33 and 15.43±7.82 ng/ml, respectively) (P
Source: Journal of the Egyptian Women’s Dermatologic Society - Category: Dermatology Tags: Original articles Source Type: research