Histopathological evidence of involvement of eccrine sweat glands in adverse cutaneous drug reactions

Background: Involvement of eccrine sweat glands in adverse cutaneous drug reactions (ACDRs) has not received sufficient interest. Objective: To examine histopathological changes in eccrine sweat glands in ACDRs. Patients and methods: Forty ACDR cases were recruited. Lesional and nonlesional biopsies underwent thorough histopathological evaluation of the eccrine apparatus. Results: The eccrine apparatus was involved in 97.5% of lesional skin biopsies, secretory coils most frequently, and in 42.1% of apparently normal skin biopsies, and the difference was statistically significant (P
Source: Journal of the Egyptian Women’s Dermatologic Society - Category: Dermatology Tags: Original articles Source Type: research