Melatonin enhances cold tolerance in drought‐primed wild‐type and abscisic acid‐deficient mutant barley
Abstract
Melatonin is involved in multiple plant developmental processes and various stress responses. To explore the roles of melatonin played as well as its association with abscisic acid (ABA) in a process of drought priming‐induced cold tolerance (DPICT), a wild‐type barley and its ABA‐deficient mutant Az34 counterpart were selected for comparison, in which the effects of melatonin application (either foliarly or rhizospherically) and/or drought priming on the cold tolerance of both types of barleys were systematically investigated. It was demonstrated that the early drought priming induced an increase of endogen...
Source: Journal of Pineal Research - July 7, 2016 Category: Research Authors: Xiangnan Li, Dun‐Xian Tan, Dong Jiang, Fulai Liu Tags: Original Article Source Type: research
Melatonin mediates selenium ‐induced tolerance to cadmium stress in tomato plants
In this study, we investigated the influence of three forms of Se (selenocysteine, sodium selenite, and sodium selenate) on the biosynthesis of melatonin and the tolerance against Cd in tomato plants. Pretreatment with different forms of Se significantly induced the biosynthesis of melatonin and its precursors (tryptophan, tryptamine, and serotonin); selenocysteine had the most marked effect on melatonin biosynthesis. Furthermore, Se and melatonin supplements significantly increased plant Cd tolerance as evidenced by decreased growth inhibition, photoinhibition, and electrolyte leakage (EL). Se‐induced Cd tolerance was c...
Source: Journal of Pineal Research - June 30, 2016 Category: Research Authors: Meng ‐Qi Li, Md. Kamrul Hasan, Cai‐Xia Li, Golam Jalal Ahammed, Xiao‐Jian Xia, Kai Shi, Yan‐Hong Zhou, Russel J. Reiter, Jing‐Quan Yu, Ming‐Xing Xu, Jie Zhou Tags: Original Article Source Type: research
2 ‐Hydroxymelatonin promotes the resistance of rice plant to multiple simultaneous abiotic stresses (combined cold and drought)
Abstract
We investigated the physiological roles of 2‐hydroxymelatonin (2‐OHMel) in rice seedlings. When they were challenged with simultaneous multiple abiotic stressors, such as a combination of cold and drought, those pretreated with 2‐OHMel were resistant, whereas no tolerance was observed in seedlings treated with either melatonin or water (control). The tolerance phenotype was associated with the induction of several transporter proteins, including the proton transporter (UCP1), potassium transporter (HKT1), and water channel protein (PIP2;1). Treatment with 2‐OHMel increased the content of the osmoprotectant...
Source: Journal of Pineal Research - June 30, 2016 Category: Research Authors: Hye ‐Jung Lee, Kyoungwhan Back Tags: Original Article Source Type: research
Elevated heart rate and nondipping heart rate as potential targets for melatonin: a review
Abstract
Elevated heart rate is a risk factor for cardiovascular and all‐cause mortalities in the general population and various cardiovascular pathologies. Insufficient heart rate decline during the night, that is, nondipping heart rate, also increases cardiovascular risk. Abnormal heart rate reflects an autonomic nervous system imbalance in terms of relative dominance of sympathetic tone. There are only a few prospective studies concerning the effect of heart rate reduction in coronary heart disease and heart failure. In hypertensive patients, retrospective analyses show no additional benefit of slowing down the heart ...
Source: Journal of Pineal Research - June 30, 2016 Category: Research Authors: Fedor Simko, Tomas Baka, Ludovit Paulis, Russel J. Reiter Tags: Review Source Type: research
The impaired myocardial ischemic tolerance in adult offspring of diabetic pregnancy is restored by maternal melatonin treatment
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - June 13, 2016 Category: Research Authors: Ling Gao, Yi‐Chao Zhao, Yan Liang, Xian‐Hua Lin, Ya‐Jing Tan, Dan‐Dan Wu, Xin‐Zhu Li, Bo‐Zhi Ye, Fan‐Qi Kong, Jian‐Zhong Sheng, He‐Feng Huang Tags: Original Article Source Type: research
Melatonin reduces endoplasmic reticulum stress and autophagy in liver of leptin ‐deficient mice
In this study, wild‐type and obese (ob/ob) mice received daily intraperitoneal injections of melatonin at a dose of 500 μg/kg body weight for 4 weeks, and the livers of these mice were used to evaluate the oxidative stress status, proteolytic (autophagy and proteasome) activity, unfolded protein response, inflammation and insulin signalling. Our results show, for the first time, that melatonin could significantly reduce endoplasmic reticulum stress in leptin‐deficient obese animals and ameliorate several symptoms that characterize this disease. Our study supports the potential of melatonin as a therapeutic treatment f...
Source: Journal of Pineal Research - June 12, 2016 Category: Research Authors: Beatriz Lux án‐Delgado, Yaiza Potes, Adrian Rubio‐González, Beatriz Caballero, Juan José Solano, María Fernández‐Fernández, Manuel Bermúdez, Marcela Rodrigues Moreira Guimarães, Ignacio Vega‐Naredo, José Antonio Boga, Ana Coto‐Montes Tags: Original Article Source Type: research
Melatonin attenuates neuronal apoptosis through up ‐regulation of K+–Cl− cotransporter KCC2 expression following traumatic brain injury in rats
In conclusion, our findings suggested that melatonin restores KCC2 expression, inhibits neuronal apoptosis and attenuates secondary brain injury after TBI, partially through activation of BDNF/ERK pathway. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - June 12, 2016 Category: Research Authors: Haijian Wu, Anwen Shao, Mingfei Zhao, Sheng Chen, Jun Yu, Jingyi Zhou, Feng Liang, Ligen Shi, Brandon J. Dixon, Zhen Wang, Chenhan Ling, Yuan Hong, Jianmin Zhang Tags: Original Article Source Type: research
Melatonin attenuates neuronal apoptosis through up‐regulation of K+–Cl− cotransporter KCC2 expression following traumatic brain injury in rats
In conclusion, our findings suggested that melatonin restores KCC2 expression, inhibits neuronal apoptosis and attenuates secondary brain injury after TBI, partially through activation of BDNF/ERK pathway. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - June 12, 2016 Category: Research Authors: Haijian Wu, Anwen Shao, Mingfei Zhao, Sheng Chen, Jun Yu, Jingyi Zhou, Feng Liang, Ligen Shi, Brandon J. Dixon, Zhen Wang, Chenhan Ling, Yuan Hong, Jianmin Zhang Tags: Original Article Source Type: research
Constitutive photomorphogenesis protein 1 (COP1) and COP9 signalosome, evolutionarily conserved photomorphogenic proteins as possible targets of melatonin
The objective of this review was to provide new information on the possible role of COP1 and COP9 as melatonin targets. The hypothesis is based on common functional aspects of melatonin and COP1 and COP9, including their dependence on light, regulation of the metabolism, and their control of tumor growth. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - June 12, 2016 Category: Research Authors: Emilio J. Sanchez‐Barcelo, Maria D. Mediavilla, Jerry Vriend, Russel J. Reiter Tags: Review Article Source Type: research
Melatonin prevents the dynamin ‐related protein 1‐dependent mitochondrial fission and oxidative insult in the cortical neurons after 1‐methyl‐4‐phenylpyridinium treatment
Abstract
Mitochondrial dysfunction and oxidative stress are involved in the pathogenesis of Parkinson's disease (PD). Mitochondrial morphology is dynamic and precisely regulated by the mitochondrial fission and fusion machinery. Aberrant mitochondrial fragmentation controlled by the mitochondrial fission protein, dynamin‐related protein 1 (Drp1), may result in cell death. Our previous results showed that melatonin protected neurons by inhibiting oxidative stress in a 1‐methyl‐4‐phenylpyridinium (MPP+)‐induced PD model. However, the effect of melatonin on mitochondrial dynamics remains uncharacterized. Herein, we ...
Source: Journal of Pineal Research - June 10, 2016 Category: Research Authors: Jih ‐Ing Chuang, I‐Ling Pan, Chia‐Yun Hsieh, Chiu‐Ying Huang, Pei‐Chun Chen, Jyh Wei Shin Tags: Original Article Source Type: research
Melatonin prevents the dynamin‐related protein 1‐dependent mitochondrial fission and oxidative insult in the cortical neurons after 1‐methyl‐4‐phenylpyridinium treatment
Abstract
Mitochondrial dysfunction and oxidative stress are involved in the pathogenesis of Parkinson's disease (PD). Mitochondrial morphology is dynamic and precisely regulated by the mitochondrial fission and fusion machinery. Aberrant mitochondrial fragmentation controlled by the mitochondrial fission protein, dynamin‐related protein 1 (Drp1), may result in cell death. Our previous results showed that melatonin protected neurons by inhibiting oxidative stress in a 1‐methyl‐4‐phenylpyridinium (MPP+)‐induced PD model. However, the effect of melatonin on mitochondrial dynamics remains uncharacterized. Herein, we ...
Source: Journal of Pineal Research - June 10, 2016 Category: Research Authors: Jih‐Ing Chuang, I‐Ling Pan, Chia‐Yun Hsieh, Chiu‐Ying Huang, Pei‐Chun Chen, Jyh Wei Shin Tags: Original Article Source Type: research
Melatonin reversed TNF α‐inhibited osteogenesis of human MSCs by stabilizing SMAD1 protein
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - June 5, 2016 Category: Research Authors: Chengjie Lian, Zizhao Wu, Bo Gao, Yan Peng, Anjing Liang, Caixia Xu, Lei Liu, Xianjian Qiu, Junjun Huang, Hang Zhou, Yifeng Cai, Peiqiang Su, Dongsheng Huang Tags: Original Manuscript Source Type: research
Elevated heart rate and non‐dipping heart rate as potential targets for melatonin: a review
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - June 5, 2016 Category: Research Authors: Fedor Simko, Tomas Baka, Ludovit Paulis, Russel J. Reiter Tags: Review Source Type: research
Melatonin mediates selenium‐induced tolerance to cadmium stress in tomato plants
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - June 5, 2016 Category: Research Authors: Meng‐Qi Li, Md.Kamrul Hasan, Cai‐Xia Li, Golam Jalal Ahammed, Xiao‐Jian Xia, Kai Shi, Yan‐Hong Zhou, Russel J. Reiter, Jing‐Quan Yu, Ming‐Xing Xu, Jie Zhou Tags: Original Manuscript Source Type: research
2‐Hydroxymelatonin promotes the resistance of rice plant to multiple simultaneous abiotic stresses (combined cold and drought)
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - June 5, 2016 Category: Research Authors: Hye‐Jung Lee, Kyoungwhan Back Tags: Original Manuscript Source Type: research
