Melatonin increases brown adipose tissue mass and function in Z ücker diabetic fatty rats: implications for obesity control
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - February 6, 2018 Category: Research Authors: Gumersindo Fern ández Vázquez, Russel J. Reiter, Ahmad Agil Tags: Original Article Source Type: research
Corrigendum
(Source: Journal of Pineal Research)
Source: Journal of Pineal Research - February 3, 2018 Category: Research Tags: CORRIGENDUM Source Type: research
Issue Information
(Source: Journal of Pineal Research)
Source: Journal of Pineal Research - February 3, 2018 Category: Research Tags: ISSUE INFORMATION Source Type: research
Melatonin redirects carbohydrates metabolism during sugar starvation in plant cells
Journal of Pineal Research, EarlyView. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - January 29, 2018 Category: Research Source Type: research
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Journal of Pineal Research, Ahead of Print. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - January 29, 2018 Category: Research Source Type: research
Protective role of melatonin in cardiac ischemia ‐reperfusion injury: From pathogenesis to targeted therapy
Journal of Pineal Research,Volume 64, Issue 3, April 2018. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - January 24, 2018 Category: Research Source Type: research
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Journal of Pineal Research,Volume 64, Issue 3, April 2018. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - January 24, 2018 Category: Research Source Type: research
Biological effects of melatonin on osteoblast/osteoclast cocultures, bone, and quality of life: Implications of a role for MT2 melatonin receptors, MEK1/2, and MEK5 in melatonin ‐mediated osteoblastogenesis
This study examines mechanisms related to the ratios of osteoblasts and osteoclasts using coculture models (transwell or layered) of human mesenchymal stem cell (MSC) and human peripheral blood monocytes (PBMCs). Human MSC/PBMC cocultures exposed to melatonin in osteogenic (OS+) medium for 21 days induced osteoblast differentiation and mineralization; however, only in layered cocultures did melatonin inhibit osteoclastogenesis. Melatonin effects were mediated through MT2 melatonin receptors, MEK1/2, and MEK5. In layered but not transwell cocultures, melatonin increased OPG:RANKL ratios by inhibiting RANKL, suggesting that...
Source: Journal of Pineal Research - January 17, 2018 Category: Research Authors: Sifat Maria, Rebekah M. Samsonraj, Fahima Munmun, Jessica Glas, Maria Silvestros, Mary P. Kotlarczyk, Ryan Rylands, Amel Dudakovic, Andre J. Wijnen, Larry T. Enderby, Holly Lassila, Bala Dodda, Vicki L. Davis, Judy Balk, Matt Burow, Bruce A. Bunnell, Paul Tags: ORIGINAL ARTICLE Source Type: research
Inhibiting MT2 ‐TFE3‐dependent autophagy enhances melatonin‐induced apoptosis in tongue squamous cell carcinoma
Abstract
Autophagy modulation is a potential therapeutic strategy for tongue squamous cell carcinoma (TSCC). Melatonin possesses significant anticarcinogenic activity. However, whether melatonin induces autophagy and its roles in cell death in TSCC are unclear. Herein, we show that melatonin induced significant apoptosis in the TSCC cell line Cal27. Apart from the induction of apoptosis, we demonstrated that melatonin‐induced autophagic flux in Cal27 cells as evidenced by the formation of GFP‐LC3 puncta, and the upregulation of LC3‐II and downregulation of SQSTM1/P62. Moreover, pharmacological or genetic blockage of ...
Source: Journal of Pineal Research - January 11, 2018 Category: Research Authors: Tengfei Fan, Huifeng Pi, Min Li, Zhenhu Ren, Zhijing He, Feiya Zhu, Li Tian, Manyu Tu, Jia Xie, Mengyu Liu, Yuming Li, Miduo Tan, Gaoming Li, Weijia Qing, Russel J. Reiter, Zhengping Yu, Hanjiang Wu, Zhou Zhou Tags: ORIGINAL ARTICLE Source Type: research
Melatonin prevents hypochlorous acid ‐mediated cyanocobalamin destruction and cyanogen chloride generation
Abstract
Hypochlorous acid (HOCl) is a potent cytotoxic oxidant generated by the enzyme myeloperoxidase (MPO) in the presence of hydrogen peroxide (H2O2) and chloride (Cl−). Elevated levels of HOCl play an important role in various pathological conditions through oxidative modification of several biomolecules. Recently, we have highlighted the ability of HOCl to mediate the destruction of the metal‐ion derivatives of tetrapyrrole macrocyclic rings such as hemoproteins and vitamin B12 (VB12) derivatives. Destruction of cyanocobalamin, a common pharmacological form of VB12 mediated by HOCl, results in the generation of t...
Source: Journal of Pineal Research - January 9, 2018 Category: Research Authors: Roohi Jeelani, Dhiman Maitra, Charalampos Chatzicharalampous, Syed Najeemuddin, Robert T. Morris, Husam M. Abu ‐Soud Tags: ORIGINAL ARTICLE Source Type: research
Protective role of melatonin in cardiac ischemia ‐reperfusion injury: from pathogenesis to targeted therapy
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - January 1, 2018 Category: Research Authors: Hao Zhou, Qiang Ma, Pingjun Zhu, Jun Ren, Russel J. Reiter, Yundai Chen Tags: Review Source Type: research
Melatonin ameliorates A β42‐induced alteration of βAPP processing secretases via the melatonin receptor through the Pin1/ GSK3β/ NF‐κB pathway in SH‐SY5Y cells
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - January 1, 2018 Category: Research Authors: Vorapin Chinchalongporn, Mayuri Shukla, Piyarat Govitrapong Tags: Original Article Source Type: research
Increase in motility and invasiveness of MCF7 cancer cells induced by nicotine is abolished by melatonin through inhibition of ERK phosphorylation
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - January 1, 2018 Category: Research Authors: Sara Proietti, Angela Catizone, Maria Grazia Masiello, Simona Dinicola, Gianmarco Fabrizi, Mirko Minini, Giulia Ricci, Roberto Verna, Russel J. Reiter, Alessandra Cucina, Mariano Bizzarri Tags: Original Article Source Type: research
Melatonin redirects carbohydrates metabolism during sugar starvation in plant cells
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - January 1, 2018 Category: Research Authors: Agnieszka Kobyli ńska, Sławomir Borek, Małgorzata M. Posmyk Tags: Original Article Source Type: research
Biological Effects of Melatonin on Osteoblast/Osteoclast Co ‐cultures, Bone and Quality of Life: implications of a role for MT2 melatonin receptors, MEK1/2 and MEK5 in melatonin‐mediated osteoblastogenesis
This study examines mechanisms related to the ratios of osteoblasts and osteoclasts using co‐culture models (transwell or layered) of human mesenchymal stem cell (MSCs) and human peripheral blood monocytes (PBMCs). Human MSCs/PBMCs co‐cultures exposed to melatonin in osteogenic (OS+) medium for 21 days induced osteoblast differentiation and mineralization; however, only in layered co‐cultures did melatonin inhibit osteoclastogenesis. Melatonin effects were mediated through MT2 melatonin receptors, MEK1/2 and MEK5. In layered but not transwell co‐cultures, melatonin increased OPG:RANKL ratios by inhibiting RANKL, su...
Source: Journal of Pineal Research - December 29, 2017 Category: Research Authors: Sifat Maria, Rebekah M. Samsonraj, Fahima Munmun, Jessica Glas, Maria Silvestros, Mary P. Kotlarczyk, Ryan Rylands, Amel Dudakovic, Andre J. van Wijnen, Larry T. Enderby, Holly Lassila, Bala Dodda, Vicki L. Davis, Judy Balk, Matt Burow, Bruce A. Bunnell, Tags: Original Article Source Type: research
