Melatonin inhibits tumorigenicity of glioblastoma stem ‐like cells via the AKT–EZH2–STAT3 signaling axis
Abstract
Glioblastoma stem‐like cells (GSCs) displaying self‐renewing and tumor‐propagating capacity play a particularly important role in maintaining tumor growth, therapeutic resistance, and tumor recurrence. Therefore, new therapeutic strategies focusing on impairing GSC maintenance are urgently needed. Here, we used GSCs isolated from surgical specimens from patients with glioblastoma multiforme (GBM) to study the roles and underlying mechanisms associated with melatonin in GSC biology. The results showed that melatonin directly targeted glioma tumor cells by altering GSC biology and inhibiting GSC proliferation....
Source: Journal of Pineal Research - June 3, 2016 Category: Research Authors: Xueran Chen, Aijun Hao, Xian Li, Zhaoxia Du, Hao Li, Hongzhi Wang, Haoran Yang, Zhiyou Fang Tags: Original Article Source Type: research
Melatonin inhibits tumorigenicity of glioblastoma stem‐like cells via the AKT–EZH2–STAT3 signaling axis
Abstract
Glioblastoma stem‐like cells (GSCs) displaying self‐renewing and tumor‐propagating capacity play a particularly important role in maintaining tumor growth, therapeutic resistance, and tumor recurrence. Therefore, new therapeutic strategies focusing on impairing GSC maintenance are urgently needed. Here, we used GSCs isolated from surgical specimens from patients with glioblastoma multiforme (GBM) to study the roles and underlying mechanisms associated with melatonin in GSC biology. The results showed that melatonin directly targeted glioma tumor cells by altering GSC biology and inhibiting GSC proliferation....
Source: Journal of Pineal Research - June 3, 2016 Category: Research Authors: Xueran Chen, Aijun Hao, Xian Li, Zhaoxia Du, Hao Li, Hongzhi Wang, Haoran Yang, Zhiyou Fang Tags: Original Article Source Type: research
On the significance of an alternate pathway of melatonin synthesis via 5 ‐methoxytryptamine: comparisons across species
Abstract
Melatonin is a phylogenetically ancient molecule. It is ubiquitously present in almost all organisms from primitive photosynthetic bacteria to humans. Its original primary function is presumable to be that of an antioxidant with other functions of this molecule having been acquired during evolution. The synthetic pathway of melatonin in vertebrates has been extensively studied. It is common knowledge that serotonin is acetylated to form N‐acetylserotonin by arylalkylamine N‐acetyltransferase (AANAT) or arylamine N‐acetyltransferase (SNAT or NAT) and N‐acetylserotonin is, subsequently, methylated to melaton...
Source: Journal of Pineal Research - May 21, 2016 Category: Research Authors: Dun ‐Xian Tan, Rüdiger Hardeland, Kyoungwhan Back, Lucien C. Manchester, Moises A. Alatorre‐Jimenez, Russel J. Reiter Tags: Review Article Source Type: research
Melatonin attenuates traumatic brain injury ‐induced inflammation: a possible role for mitophagy
This study aimed to examine the effect of melatonin on inflammation via elimination of damaged mitochondria after controlled cortical impact, an in vivo model of traumatic brain injury (TBI). Here, we demonstrated that inhibition of mitophagy, the selective degradation of damaged mitochondria by autophagy, markedly enhanced inflammation induced by TBI. Melatonin treatment activated mitophagy through the mTOR pathway, then to attenuate TBI‐induced inflammation. Furthermore, treatment with melatonin significantly ameliorated neuronal death and behavioral deficits after TBI, while 3‐methyladenine reversed this effect by ...
Source: Journal of Pineal Research - May 21, 2016 Category: Research Authors: Chao Lin, Honglu Chao, Zheng Li, Xiupeng Xu, Yinlong Liu, Lijun Hou, Ning Liu, Jing Ji Tags: Original Article Source Type: research
Melatonin inhibits the sphingosine kinase 1/sphingosine ‐1‐phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin
This study investigate whether modulation of the SphK1/S1P system associates to the beneficial effects of melatonin in an animal model of acute liver failure (ALF) induced by the rabbit hemorrhagic disease virus (RHDV). Rabbits were experimentally infected with 2 × 104 hemagglutination units of a RHDV isolate and received 20 mg/kg of melatonin at 0, 12, and 24 hr postinfection. Liver mRNA levels, protein concentration, and immunohistochemical labeling for SphK1 increased in RHDV‐infected rabbits. S1P production and protein expression of the S1PR1 receptor were significantly elevated following RHDV infection. These e...
Source: Journal of Pineal Research - May 21, 2016 Category: Research Authors: Irene Crespo, Beatriz San ‐Miguel, Diana I. Sánchez, Bárbara González‐Fernández, Marcelino Álvarez, Javier González‐Gallego, María J. Tuñón Tags: Original Article Source Type: research
