Issue Information
(Source: Journal of Pineal Research)
Source: Journal of Pineal Research - September 7, 2017 Category: Research Tags: ISSUE INFORMATION Source Type: research

Melatonin alleviates weanling stress in mice: involvement of intestinal microbiota
In conclusion, melatonin affects body weight gain, intestinal morphology, and intestinal ETEC infection through intestinal microbiota in weanling mice. The findings highlight the importance of intestinal microbiota in mediating the various physiological functions of melatonin in the host. This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - September 1, 2017 Category: Research Authors: Wenkai Ren, Peng Wang, Jiameng Yan, Gang Liu, Benhua Zeng, Tarique Hussain, Can Peng, Jie Yin, Bie Tan, Tiejun Li, Hong Wei, Guoqiang Zhu, Russel J. Reiter, Yulong Yin Tags: Original Article Source Type: research

Melatonin improves the fertilization capacity and developmental ability of bovine oocytes by regulating cytoplasmic maturation events
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - August 23, 2017 Category: Research Authors: Xue ‐Ming Zhao, Na Wang, Hai‐Sheng Hao, Chong‐Yang Li, Ya‐Han Zhao, Chang‐Liang Yan, Hao‐Yu Wang, Wei‐Hua Du, Dong Wang, Yan Liu, Yun‐Wei Pang, Hua‐Bin Zhu Tags: Original Article Source Type: research

Melatonin limits paclitaxel ‐induced mitochondrial dysfunction in vitro and protects against paclitaxel‐induced neuropathic pain in the rat
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - August 22, 2017 Category: Research Authors: Helen F. Galley, Barry McCormick, Kirsten L. Wilson, Damon A. Lowes, Lesley Colvin, Carole Torsney Tags: Original Article Source Type: research

Protection of melatonin in experimental models of newborn hypoxic ‐ischemic brain injury through MT1 receptor
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - August 10, 2017 Category: Research Authors: Bharati Sinha, Qiaofeng Wu, Wei Li, Yanyang Tu, Ana C. Sirianni, Yanchun Chen, Jiying Jiang, Xinmu Zhang, Shuanhu Zhou, Wu Chen, Russel J. Reiter, Simon Manning, Nirav J. Patel, Ali M. Aziz ‐Sultan, Terri E. Inder, Robert M. Friedlander, Jianfang Fu, Xi Tags: Original Article Source Type: research

Melatonin reduces inflammatory response in peripheral T helper lymphocytes from relapsing ‐remitting multiple sclerosis patients
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - August 10, 2017 Category: Research Authors: Nuria Álvarez‐Sánchez, Ivan Cruz‐Chamorro, María Díaz‐Sánchez, Helia Sarmiento‐Soto, Pablo Medrano‐Campillo, Alicia Martínez‐López, Patricia Judith Lardone, Juan Miguel Guerrero, Antonio Carrillo‐Vico Tags: Original Article Source Type: research

Cadmium ‐induced melatonin synthesis in rice requires light, hydrogen peroxide, and nitric oxide: key regulatory roles for tryptophan decarboxylase and caffeic acid O‐methyltransferase
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - August 9, 2017 Category: Research Authors: Kyungjin Lee, Geun ‐Hee Choi, Kyoungwhan Back Tags: Original Article Source Type: research

Rapid modulation of the silent information regulator 1 by melatonin after hypoxia ‐ischemia in the neonatal rat brain
This study aimed to gain more insight into the role of SIRT1 in the protective effect of melatonin after HI by studying the early (1 hour) modulation of SIRT1 and its downstream targets, and the consequences on necrosis, apoptosis, autophagy, and glial cell activation. We found that melatonin administered 5 minutes after the ischemic insult significantly reduced necrotic cell death assessed 1 hour after its administration. In parallel, we found a reduced activation of the early phases of intrinsic apoptosis, detected by reduced BAX translocation to the mitochondria and preservation of the mitochondrial expression of cyt...
Source: Journal of Pineal Research - August 7, 2017 Category: Research Authors: Silvia Carloni, Giulia Riparini, Giuseppe Buonocore, Walter Balduini Tags: ORIGINAL ARTICLE Source Type: research

Maternal administration of melatonin exerts short ‐ and long‐term neuroprotective effects on the offspring from lipopolysaccharide‐treated mice
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - August 4, 2017 Category: Research Authors: Ana Paula Dom ínguez Rubio, Fernando Correa, Julieta Aisemberg, Damián Dorfman, María Victoria Bariani, Ruth Rosenstein, María Zorrilla Zubilete, Ana María Franchi Tags: Original Article Source Type: research

Melatonin ameliorates hypoglycemic stress ‐induced brain endothelial tight junction injury by inhibiting protein nitration of TP53‐induced glycolysis and apoptosis regulator (TIGAR)
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - August 4, 2017 Category: Research Authors: Cheng ‐kun Wang, Muhammad Masood Ahmed, Quan Jiang, Nan‐nan Lu, Chao Tan, Yin‐ping Gao, Qaisar Mahmood, Dan‐yang Chen, Kohji Fukunaga, Mei Li, Zhong Chen, Christopher S. Wilcox, Ying‐mei Lu, Zheng‐Hong Qin, Feng Han Tags: Original Article Source Type: research

Issue Information
(Source: Journal of Pineal Research)
Source: Journal of Pineal Research - August 2, 2017 Category: Research Tags: ISSUE INFORMATION Source Type: research

Melatonin suppresses platelet activation and function against cardiac ischemia/reperfusion injury via PPAR γ/FUNDC1/mitophagy pathways
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - July 27, 2017 Category: Research Authors: Hao Zhou, Dandan Li, Pingjun Zhu, Shunying Hu, Nan Hu, Sai Ma, Ying Zhang, Tianwen Han, Jun Ren, Feng Cao, Yundai Chen Tags: Original Article Source Type: research

Melatonin impedes Tet1 ‐dependent mGluR5 promoter demethylation to relieve pain
In conclusion, melatonin relieves pain by impeding Tet1‐dependent demethylation of mGluR5 in dorsal horn neurons through the MT2 receptor. Our findings link melatonin/MT2 signaling to Tet1‐dependent epigenetic demethylation of nociceptive genes for the first time and suggest melatonin as a promising therapy for the treatment of pain. This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - July 18, 2017 Category: Research Authors: Ming ‐Chun Hsieh, Yu‐Cheng Ho, Cheng‐Yuan Lai, Dylan Chou, Hsueh‐Hsiao Wang, Gin‐Den Chen, Tzer‐Bin Lin, Hsien‐Yu Peng Tags: Original Article Source Type: research

Melatonin protects against maternal obesity ‐associated oxidative stress and meiotic defects in oocytes via the SIRT3‐SOD2‐dependent pathway
Abstract Maternal obesity in humans is associated with poor outcomes across the reproductive spectrum. Emerging evidence indicates that these defects are likely attributed to factors within the oocyte. Although various molecules and pathways may contribute to impaired oocyte quality, prevention of fertility issues associated with maternal obesity is a challenge. Using mice fed a high‐fat diet (HFD) as an obesity model, we document spindle disorganization, chromosome misalignment, and elevated reactive oxygen species (ROS) levels in oocytes from obese mice. Oral administration of melatonin to HFD mice not only reduces ROS...
Source: Journal of Pineal Research - July 18, 2017 Category: Research Authors: Longsen Han, Haichao Wang, Ling Li, Xiaoyan Li, Juan Ge, Russel J. Reiter, Qiang Wang Tags: ORIGINAL ARTICLE Source Type: research

Melatonin inhibits nucleus pulposus (NP) cell proliferation and extracellular matrix (ECM) remodeling via the melatonin membrane receptors mediated PI3K ‐Akt pathway
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - July 18, 2017 Category: Research Authors: Zheng Li, Xingye Li, Chong Chen, Matthew T. V. Chan, William Ka Kei Wu, Jianxiong Shen Tags: Original Article Source Type: research