Melatonin regulates lipid metabolism in porcine oocytes
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - December 31, 2016 Category: Research Authors: Jun ‐Xue Jin, Sanghoon Lee, Anukul Taweechaipaisankul, Geon A Kim, Byeong Chun Lee Tags: Original Article Source Type: research
Corrigendum
(Source: Journal of Pineal Research)
Source: Journal of Pineal Research - December 25, 2016 Category: Research Tags: CORRIGENDUM Source Type: research
Issue Information
(Source: Journal of Pineal Research)
Source: Journal of Pineal Research - December 25, 2016 Category: Research Tags: Issue Information Source Type: research
Melatonin is required for H2O2 ‐ and NO‐mediated defense signaling through MAPKKK3 and OXI1 in Arabidopsis thaliana
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - November 17, 2016 Category: Research Authors: Hyoung Yool Lee, Kyoungwhan Back Tags: Original Article Source Type: research
IGFBP3 and MAPK/ERK signaling mediates melatonin ‐induced antitumor activity in prostate cancer
Abstract
Treatment of prostate cancer (PCa), a leading cause of cancer among males, lacks successful strategies especially in advanced, hormone‐refractory stages. Some clinical studies have shown an increase in neuroendocrine‐like cells parallel to the tumor progression but their exact role is a matter of debate. The prostate is a well‐known target for melatonin, which reduces PCa cells proliferation and induces neuroendocrine differentiation. To evaluate the mechanisms underlying the indole effects on neuroendocrine differentiation and its impact on PCa progression, we used a cell culture model (LNCaP) and a murine ...
Source: Journal of Pineal Research - November 8, 2016 Category: Research Authors: Juan C. Mayo, David Hevia, Isabel Quiros ‐Gonzalez, Aida Rodriguez‐Garcia, Pedro Gonzalez‐Menendez, Vanesa Cepas, Iván Gonzalez‐Pola, Rosa M. Sainz Tags: Original Article Source Type: research
Melatonin promotes circadian rhythm ‐induced proliferation through interaction of Clock/HDAC3/c‐Myc in mice adipose tissue
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - October 31, 2016 Category: Research Authors: Zhenjiang Liu, Lu Gan, Dan Luo, Chao Sun Tags: Original Article Source Type: research
Long term melatonin treatment delays ovarian aging
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - October 31, 2016 Category: Research Authors: Hiroshi Tamura, Mai Kawamoto, Shun Sato, Isao Tamura, Ryo Maekawa, Toshiaki Taketani, Hiromi Aasada, Eiichi Takaki, Akira Nakai, Russel J. Reiter, Norihiro Sugino Tags: Original Article Source Type: research
Melatonin synergizes the chemotherapeutic effect of 5 ‐fluorouracil in colon cancer by suppressing PI3K/AKT and NF‐κB/iNOS signaling pathways
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - October 31, 2016 Category: Research Authors: Yue Gao, Xiangsheng Xiao, Changlin Zhang, Wendan Yu, Wei Guo, Zhifeng Zhang, Zhenglin Li, Xu Feng, Jiaojiao Hao, Kefang Zhang, Bingyi Xiao, Miao Chen, Wenlin Huang, Shunbin Xiong, Xiaojun Wu, Wuguo Deng Tags: Original Article Source Type: research
Novel protective role of nuclear melatonin receptor ROR α in diabetic cardiomyopathy
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - October 31, 2016 Category: Research Authors: Yichao Zhao, Longwei Xu, Song Ding, Nan Lin, Qingqi Ji, Lingchen Gao, Yuanyuan Su, Jun Pu, Ben He Tags: Original Article Source Type: research
Melatonin attenuates postmyocardial infarction injury via increasing Tom70 expression
Abstract
Mitochondrial dysfunction leads to reactive oxygen species (ROS) overload, exacerbating injury in myocardial infarction (MI). As a receptor for translocases in the outer mitochondrial membrane (Tom) complex, Tom70 has an unknown function in MI, including melatonin‐induced protection against MI injury. We delivered specific small interfering RNAs against Tom70 or lentivirus vectors carrying Tom70a sequences into the left ventricles of mice or to cultured neonatal murine ventricular myocytes (NMVMs). At 48 h post‐transfection, the left anterior descending coronary arteries of mice were permanently ligated, whil...
Source: Journal of Pineal Research - October 31, 2016 Category: Research Authors: Hai ‐Feng Pei, Juan‐Ni Hou, Fei‐Peng Wei, Qiang Xue, Fan Zhang, Cheng‐Fei Peng, Yi Yang, Yue Tian, Juan Feng, Jin Du, Lei He, Xiu‐Chuan Li, Er‐He Gao, De Li, Yong‐Jian Yang Tags: Original Article Source Type: research
Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1
Abstract
Melatonin reportedly protects against several cardiovascular diseases including ischemia/reperfusion (I/R), atherosclerosis, and hypertension. The present study investigated the effects and mechanisms of melatonin on cardiomyocyte autophagy, apoptosis, and mitochondrial injury in the context of myocardial infarction (MI). We demonstrated that melatonin significantly alleviated cardiac dysfunction after MI. Four weeks after MI, echocardiography and Masson staining indicated that melatonin notably mitigated adverse left ventricle remodeling. The mechanism may be associated with increased autophagy, reduced apoptosis...
Source: Journal of Pineal Research - October 24, 2016 Category: Research Authors: Jianqiang Hu, Lei Zhang, Yang Yang, Yanjie Guo, Yanhong Fan, Mingming Zhang, Wanrong Man, Erhe Gao, Wei Hu, Russel J. Reiter, Haichang Wang, Dongdong Sun Tags: Original Article Source Type: research
Issue Information
(Source: Journal of Pineal Research)
Source: Journal of Pineal Research - October 23, 2016 Category: Research Tags: Issue Information Source Type: research
Melatonin promotes cardiomyogenesis of embryonic stem cells via inhibition of HIF ‐1α stabilization
In this study, by employing differentiating mouse embryonic stem cells, we report that melatonin significantly upregulated the expression of cardiac cell‐specific markers (myosin heavy chains six and seven) as well as the percentage of myosin heavy chain‐positive cells. Importantly, melatonin decreased HIF‐1α stabilization and transcriptional activity and, in contrast, induced HIF‐2α stabilization. Interestingly, the deletion of HIF‐1α completely inhibited the pro‐cardiomyogenic effect of melatonin as well as the melatonin‐mediated HIF‐2α stabilization. Moreover, melatonin increased Sirt‐1 levels in a...
Source: Journal of Pineal Research - October 15, 2016 Category: Research Authors: Jana Kudov á, Ondřej Vašíček, Milan Číž, Lukáš Kubala Tags: Original Article Source Type: research
IGFBP3 and MAPK/ERK signaling mediates melatonin ‐induced anti‐tumor activity in prostate cancer
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - October 12, 2016 Category: Research Authors: Juan C. Mayo, David Hevia, Isabel Quiros ‐Gonzalez, Aida Rodriguez‐Garcia, Pedro Gonzalez‐Menendez, Vanesa Cepas, Iván Gonzalez‐Pola, Rosa M. Sainz Tags: Original Article Source Type: research
Melatonin Enhances Survival and Preserves Functional Integrity of Stem Cells: A Review
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - October 12, 2016 Category: Research Authors: Mel S. Lee, Tsung ‐Cheng Yin, Pei‐Hsun Sung, John Y. Chiang, Cheuk‐Kwan Sun, Hon‐Kan Yip Tags: Review Source Type: research
