Melatonin as an Antioxidant: Under Promises but Over Delivers
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - August 7, 2016 Category: Research Authors: Russel J. Reiter, Juan C. Mayo, Dun ‐Xian Tan, Rosa M. Sainz, Moises Alatorre‐Jimenez, Lilian Qin Tags: Review Source Type: research
Issue Information
(Source: Journal of Pineal Research)
Source: Journal of Pineal Research - August 2, 2016 Category: Research Tags: Issue Information Source Type: research
Melatonin antagonizes cadmium ‐induced neurotoxicity by activating the transcription factor EB‐dependent autophagy–lysosome machinery in mouse neuroblastoma cells
Abstract
Cadmium (Cd), a highly ubiquitous heavy metal, induces neurotoxicity. Melatonin, a major secretory product of the pineal gland, protects against Cd‐induced neurotoxicity. However, the mechanism that accounts for this protection remains to be elucidated. Herein, we exposed mouse neuroblastoma cells (Neuro‐2a cells) to different concentrations of cadmium chloride (CdCl2) (12.5, 25, and 50 μ mol L−1) for 24 hours. We showed that Cd inhibits autophagosome–lysosome fusion and impairs lysosomal function, subsequently leading to nerve cell death. In addition, Cd decreases the level of transcription factor EB...
Source: Journal of Pineal Research - August 2, 2016 Category: Research Authors: Min Li, Huifeng Pi, Zhiqi Yang, Russel J. Reiter, Shangcheng Xu, Xiaowei Chen, Chunhai Chen, Lei Zhang, Min Yang, Yuming Li, Pan Guo, Gaoming Li, Manyu Tu, Li Tian, Jia Xie, Mindi He, Yonghui Lu, Min Zhong, Yanwen Zhang, Zhengping Yu, Zhou Zhou Tags: Original Article Source Type: research
Melatonin ‐induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - August 1, 2016 Category: Research Authors: N éstor Prieto‐Domínguez, Raquel Ordóñez, Anna Fernández, Carolina Méndez‐Blanco, Anna Baulies, Carmen Garcia‐Ruiz, José C. Fernández‐Checa, José L. Mauriz, Javier González‐Gallego Tags: Original Article Source Type: research
Melatonin enhances thermotolerance by promoting cellular protein protection in tomato plants
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - July 31, 2016 Category: Research Authors: Wen Xu, Shu ‐Yu Cai, Yun Zhang, Yu Wang, Golam Jalal Ahammed, Xiao‐Jian Xia, Kai Shi, Yan‐Hong Zhou, Jing‐Quan Yu, Russel J. Reiter, Jie Zhou Tags: Original Article Source Type: research
The cardioprotective effect of melatonin and exendin ‐4 treatment in a rat model of cardiorenal syndrome
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - July 28, 2016 Category: Research Authors: Sarah Chua, Fan ‐Yen Lee, Hsin‐Ju Chiang, Kuan‐Hung Chen, Hung‐I Lu, Yen‐Ta Chen, Chih‐Chao Yang, Kun‐Chen Lin, Yi‐Ling Chen, Gour‐Shenq Kao, Chih‐Hung Chen, Hsueh‐Wen Chang, Hon‐Kan Yip Tags: Original Article Source Type: research
Melatonin enhances hyperthermia ‐induced apoptotic cell death in human leukemia cells
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - July 27, 2016 Category: Research Authors: Carlos Quintana, Javier Cabrera, Juan Perdomo, Francisco Est évez, Juan F. Loro, Russel J. Reiter, José Quintana Tags: Original Article Source Type: research
Melatonin reversed tumor necrosis factor ‐alpha‐inhibited osteogenesis of human mesenchymal stem cells by stabilizing SMAD1 protein
This study demonstrated that melatonin rescued TNFα‐inhibited osteogenesis of human mesenchymal stem cells and that the interactions between SMURF1 and SMAD1 mediated the crosstalk between melatonin signaling and TNFα signaling. Additionally, melatonin treatment was found to downregulate TNFα‐induced SMURF1 expression and then decrease SMURF1‐mediated ubiquitination and degradation of SMAD1 protein, leading to steady bone morphogenetic protein‐SMAD1 signaling activity and restoration of TNFα‐impaired osteogenesis. Thus, melatonin has prospects for treating osteoporosis caused by inflammatory factors due to it...
Source: Journal of Pineal Research - July 24, 2016 Category: Research Authors: Chengjie Lian, Zizhao Wu, Bo Gao, Yan Peng, Anjing Liang, Caixia Xu, Lei Liu, Xianjian Qiu, Junjun Huang, Hang Zhou, Yifeng Cai, Peiqiang Su, Dongsheng Huang Tags: Original Article Source Type: research
Melatonin modulates neonatal brain inflammation through ER stress, autophagy and miR ‐34a/SIRT1 pathway
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - July 22, 2016 Category: Research Authors: Silvia Carloni, G éraldine Favrais, Elie Saliba, Maria Cristina Albertini, Sylvie Chalon, Mariangela Longini, Pierre Gressens, Giuseppe Buonocore, Walter Balduini Tags: Original Article Source Type: research
Melatonin antagonizes cadmium‐induced neurotoxicity by activating the transcription factor EB ‐dependent autophagy‐lysosome machinery in mouse neuroblastoma cells
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - July 11, 2016 Category: Research Authors: Min Li, Huifeng Pi, Zhiqi Yang, Russel J. Reiter, Shangcheng Xu, Xiaowei Chen, Chunhai Chen, Lei Zhang, Yang Min, Yuming Li, Pan Guo, Gaoming Li, Manyu Tu, Li Tian, Jia Xie, Mindi He, Yonghui Lu, Min Zhong, Yanwen Zhang, Zhengping Yu, Zhou Zhou Tags: Original Article Source Type: research
A label ‐free differential proteomics analysis reveals the effect of melatonin on promoting fruit ripening and anthocyanin accumulation upon postharvest in tomato
Abstract
To better understand the function of melatonin in tomato fruit ripening and quality improvement, a label‐free quantitation method was used to investigate the proteins that differ between the control (CK) and 50 μm melatonin treatment (M50) fruits. Proteomics data identified 241 proteins that were significantly influenced by melatonin. These proteins were involved in several ripening‐related pathways, including cell wall metabolism, oxidative phosphorylation, carbohydrate, and fatty acid metabolism. Moreover, the application of exogenous melatonin increased eight proteins that are related to anthocyanin accumu...
Source: Journal of Pineal Research - July 10, 2016 Category: Research Authors: Qianqian Sun, Na Zhang, Jinfang Wang, Yunyun Cao, Xingsheng Li, Haijun Zhang, Lei Zhang, Dun ‐Xian Tan, Yang‐Dong Guo Tags: Original Article Source Type: research
A label‐free differential proteomics analysis reveals the effect of melatonin on promoting fruit ripening and anthocyanin accumulation upon postharvest in tomato
Abstract
To better understand the function of melatonin in tomato fruit ripening and quality improvement, a label‐free quantitation method was used to investigate the proteins that differ between the control (CK) and 50 μm melatonin treatment (M50) fruits. Proteomics data identified 241 proteins that were significantly influenced by melatonin. These proteins were involved in several ripening‐related pathways, including cell wall metabolism, oxidative phosphorylation, carbohydrate, and fatty acid metabolism. Moreover, the application of exogenous melatonin increased eight proteins that are related to anthocyanin accumu...
Source: Journal of Pineal Research - July 10, 2016 Category: Research Authors: Qianqian Sun, Na Zhang, Jinfang Wang, Yunyun Cao, Xingsheng Li, Haijun Zhang, Lei Zhang, Dun‐Xian Tan, Yang‐Dong Guo Tags: Original Article Source Type: research
Melatonin antagonizes cadmium ‐induced neurotoxicity by activating the transcription factor EB ‐dependent autophagy‐lysosome machinery in mouse neuroblastoma cells
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - July 9, 2016 Category: Research Authors: Min Li, Huifeng Pi, Zhiqi Yang, Russel J. Reiter, Shangcheng Xu, Xiaowei Chen, Chunhai Chen, Lei Zhang, Yang Min, Yuming Li, Pan Guo, Gaoming Li, Manyu Tu, Li Tian, Jia Xie, Mindi He, Yonghui Lu, Min Zhong, Yanwen Zhang, Zhengping Yu, Zhou Zhou Tags: Original Article Source Type: research
Melatonin enhances cold tolerance in drought ‐primed wild‐type and abscisic acid‐deficient mutant barley
Abstract
Melatonin is involved in multiple plant developmental processes and various stress responses. To explore the roles of melatonin played as well as its association with abscisic acid (ABA) in a process of drought priming‐induced cold tolerance (DPICT), a wild‐type barley and its ABA‐deficient mutant Az34 counterpart were selected for comparison, in which the effects of melatonin application (either foliarly or rhizospherically) and/or drought priming on the cold tolerance of both types of barleys were systematically investigated. It was demonstrated that the early drought priming induced an increase of endogen...
Source: Journal of Pineal Research - July 7, 2016 Category: Research Authors: Xiangnan Li, Dun ‐Xian Tan, Dong Jiang, Fulai Liu Tags: Original Article Source Type: research
Issue Information
(Source: Journal of Pineal Research)
Source: Journal of Pineal Research - July 7, 2016 Category: Research Tags: Issue Information Source Type: research
