Melatonin promotes circadian rhythm ‐induced proliferation through Clock/histone deacetylase 3/c‐Myc interaction in mouse adipose tissue
Abstract
Melatonin is synthesized in the pineal gland and controls circadian rhythm of peripheral adipose tissue, resulting in changes in body weight. Although core regulatory components of clock rhythmicity have been defined, insight into the mechanisms of circadian rhythm‐mediated proliferation in adipose tissue is still limited. Here, we showed that melatonin (20 mg/kg/d) promoted circadian and proliferation processes in white adipose tissue. The circadian amplitudes of brain and muscle aryl hydrocarbon receptor nuclear translocator‐like 1 (Bmal1, P<.05) and circadian locomotor output cycles kaput (Clock, P<....
Source: Journal of Pineal Research - March 20, 2017 Category: Research Authors: Zhenjiang Liu, Lu Gan, Dan Luo, Chao Sun Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
(Source: Journal of Pineal Research)
Source: Journal of Pineal Research - March 18, 2017 Category: Research Tags: ISSUE INFORMATION Source Type: research
Melatonin restores hippocampal neural precursor cell proliferation and prevents cognitive deficits induced by jet lag simulation in adult mice
Abstract
Frequent flyers and shift workers undergo circadian dysrhythmia with adverse impact on body and mind. The circadian rhythm disorder “jet lag” disturbs hippocampal neurogenesis and spatial cognition, which represent morphological and functional adult brain plasticity. This raises the question if pro‐neurogenic stimuli might prevent those consequences. However, suitable measures to mitigate jet lag‐induced adverse effects on brain plasticity have been neglected so far. Here, we used adult C57Bl6 mice to investigate the pro‐neurogenic stimuli melatonin (8 mg/kg i.p.) as well as environmental enrichment as ...
Source: Journal of Pineal Research - March 11, 2017 Category: Research Authors: Deetje Iggena, York Winter, Barbara Steiner Tags: ORIGINAL ARTICLE Source Type: research
Melatonin promotes sorafenib ‐induced apoptosis through synergistic activation of JNK/c‐jun pathway in human hepatocellular carcinoma
This study demonstrates that melatonin in combination with sorafenib synergistically inhibits proliferation and induces apoptosis in human HCC cells; therefore, supplementation of sorafenib with melatonin may serve as a potential therapeutic choice for advanced HCC. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - March 5, 2017 Category: Research Authors: Shibo Lin, Katrin Hoffmann, Chao Gao, Marius Petrulionis, Ingrid Herr, Peter Schemmer Tags: ORIGINAL ARTICLE Source Type: research
Melatonin reverses H2O2 ‐induced senescence in SH‐SY5Y cells by enhancing autophagy via sirtuin 1 deacetylation of the RelA/p65 subunit of NF‐κB
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - February 28, 2017 Category: Research Authors: Chutikorn Nopparat, Puritat Sinjanakhom, Piyarat Govitrapong Tags: Original Article Source Type: research
An AANAT/ASMT transgenic animal model constructed with CRISPR/Cas9 system serving as the mammary gland bioreactor to produce melatonin ‐enrich milk in sheep
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - February 28, 2017 Category: Research Authors: Teng Ma, Jingli Tao, Minghui Yang, Changjiu He, Xiuzhi Tian, Xiaosheng Zhang, Jinlong Zhang, Shoulong Deng, Jianzhong Feng, Zhenzhen Zhang, Jing Wang, Pengyun Ji, Yukun Song, Pingli He, Hongbing Han, Juncai Fu, Zhengxing Lian, Guoshi Liu Tags: Original Article Source Type: research
Melatonin regulates PARP1 to control the senescence ‐associated secretory phenotype (SASP) in human fetal lung fibroblast cells
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - February 28, 2017 Category: Research Authors: Songtao Yu, Xiaojiao Wang, Peiliang Geng, Xudong Tang, Lisha Xiang, Xin Lu, Jianjun Li, Zhihua Ruan, Jianfang Chen, Ganfeng Xie, Zhe Wang, Juanjuan Ou, Yuan Peng, Xi Luo, Xuan Zhang, Yan Dong, Hongshan Chen, Houjie Liang Tags: Original Article Source Type: research
Melatonin protects against lipid ‐induced mitochondrial dysfunction in hepatocytes and inhibits stellate cell activation during hepatic fibrosis in mice
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - February 28, 2017 Category: Research Authors: Nabanita Das, Ashok Mandala, Shamreen Naaz, Suresh Giri, Mukul Jain, Debasish Bandyopadhyay, Russel J. Reiter, Sib Sankar Roy Tags: Original Article Source Type: research
Overexpression of rice serotonin N ‐acetyltransferase 1 in transgenic rice plants confers resistance to cadmium and senescence and increases grain yield
Abstract
While ectopic overexpression of serotonin N‐acetyltransferase (SNAT) in plants has been accomplished using animal SNAT genes, ectopic overexpression of plant SNAT genes in plants has not been investigated. Because the plant SNAT protein differs from that of animals in its subcellular localization and enzyme kinetics, its ectopic overexpression in plants would be expected to give outcomes distinct from those observed from overexpression of animal SNAT genes in transgenic plants. Consistent with our expectations, we found that transgenic rice plants overexpressing rice (Oryza sativa) SNAT1 (OsSNAT1) did not show e...
Source: Journal of Pineal Research - February 28, 2017 Category: Research Authors: Kyungjin Lee, Kyoungwhan Back Tags: ORIGINAL ARTICLE Source Type: research
Effects of melatonin on seedling growth, mineral nutrition, and nitrogen metabolism in cucumber under nitrate stress
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - February 23, 2017 Category: Research Authors: Ruimin Zhang, Yunkuo Sun, Zeyu Liu, Wen Jin, Yan Sun Tags: Original Article Source Type: research
Olanzapine ‐induced Early Cardiovascular Effects are Mediated by the Biological Clock and Prevented by Melatonin
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - February 21, 2017 Category: Research Authors: Francisco Romo ‐Nava, Frederik N. Buijs, Marcela Valdés‐Tovar, Gloria Benítez‐King, MariCarmen Basualdo, Mercedes Perusquía, Gerhard Heinze, Carolina Escobar, Ruud M. Buijs Tags: Original Article Source Type: research
Melatonin systemically ameliorates drought stress ‐induced damage in Medicago sativa plants by modulating nitro‐oxidative homeostasis and proline metabolism
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - February 21, 2017 Category: Research Authors: Chrystalla Antoniou, Giannis Chatzimichail, Rafaella Xenofontos, Giannis Pavlou, Evangelia Panagiotou, Anastasis Christou, Vasileios Fotopoulos Tags: Original Article Source Type: research
Novel protective role of the circadian nuclear receptor retinoic acid ‐related orphan receptor‐α in diabetic cardiomyopathy
Abstract
Diabetic cardiomyopathy is a major complication that significantly contributes to morbidity and mortality in diabetics with few therapies. Moreover, antidiabetic drugs reported inconsistent or even adverse cardiovascular effects, suggesting that it is important to exploit novel therapeutic targets against diabetic cardiomyopathy. Here, we observed that the nuclear melatonin receptor, the retinoic acid‐related orphan receptor‐α (RORα), was downregulated in diabetic hearts. By utilizing a mouse line with RORα disruption, we demonstrated that RORα deficiency led to significantly augmented diastolic dysfunctio...
Source: Journal of Pineal Research - February 21, 2017 Category: Research Authors: Yichao Zhao, Longwei Xu, Song Ding, Nan Lin, Qingqi Ji, Lingchen Gao, Yuanyuan Su, Ben He, Jun Pu Tags: ORIGINAL ARTICLE Source Type: research
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(Source: Journal of Pineal Research)
Source: Journal of Pineal Research - February 17, 2017 Category: Research Tags: Issue Information Source Type: research
Melatonin and sirtuins: A “not‐so unexpected” relationship
Abstract
Epigenetic modifications, including methylation or acetylation as well as post‐transcriptional modifications, are mechanisms used by eukaryotic cells to increase the genome diversity in terms of differential gene expression and protein diversity. Among these modifying enzymes, sirtuins, a class III histone deacetylase (HDAC) enzymes, are of particular importance. Sirtuins regulate the cell cycle, DNA repair, cell survival, and apoptosis, thus having important roles in normal and cancer cells. Sirtuins can also regulate metabolic pathways by changing preference for glycolysis under aerobic conditions as well as g...
Source: Journal of Pineal Research - February 13, 2017 Category: Research Authors: Juan C. Mayo, Rosa M. Sainz, Pedro Gonz ález Menéndez, Vanesa Cepas, Dun‐Xian Tan, Russel J. Reiter Tags: REVIEW ARTICLE Source Type: research
