Melatonin promotes sorafenib ‐induced apoptosis through synergistic activation of JNK/c‐jun pathway in human hepatocellular carcinoma

This study demonstrates that melatonin in combination with sorafenib synergistically inhibits proliferation and induces apoptosis in human HCC cells; therefore, supplementation of sorafenib with melatonin may serve as a potential therapeutic choice for advanced HCC.

Source: Journal of Pineal Research - March 5, 2017 Category: Research Authors: Shibo Lin, Katrin Hoffmann, Chao Gao, Marius Petrulionis, Ingrid Herr, Peter Schemmer Tags: ORIGINAL ARTICLE Source Type: research