Melatonin protects against the pathological cardiac hypertrophy induced by transverse aortic constriction through activating PGC ‐1β: in vivo and in vitro studies
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - July 14, 2017 Category: Research Authors: Mengen Zhai, Zhenhua Liu, Bin Zhang, Lin Jing, Buying Li, Kaifeng Li, Xiuju Chen, Meng Zhang, Bo Yu, Kai Ren, Yang Yang, Wei Yi, Jian Yang, Jincheng Liu, Dinghua Yi, Hongliang Liang, Zhenxiao Jin, Russel J. Reiter, Weixun Duan, Shiqiang Yu Tags: Original Article Source Type: research
Rapid modulation of the silent information regulator 1 (SIRT1) by melatonin after hypoxia ‐ischemia in the neonatal rat brain
This study aimed to gain more insight into the role of SIRT1 in the protective effect of melatonin after HI by studying the early (1h) modulation of SIRT1 and its downstream targets, and the consequences on necrosis, apoptosis, autophagy and glial cell activation. We found that melatonin administered 5 min after the ischemic insult significantly reduced necrotic cell death assessed 1h after its administration. In parallel, we found a reduced activation of the early phases of intrinsic apoptosis, detected by reduced BAX translocation to the mitochondria and preservation of the mitochondrial expression of cytochrome C, indic...
Source: Journal of Pineal Research - July 14, 2017 Category: Research Authors: Silvia Carloni, Giulia Riparini, Giuseppe Buonocore, Walter Balduini Tags: Original Article Source Type: research
Issue Information
(Source: Journal of Pineal Research)
Source: Journal of Pineal Research - July 3, 2017 Category: Research Tags: ISSUE INFORMATION Source Type: research
Melatonin protects against maternal obesity ‐associated oxidative stress and meiotic defects in oocytes via the SIRT3‐SOD2 dependent pathway
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - June 28, 2017 Category: Research Authors: Longsen Han, Haichao Wang, Ling Li, Xiaoyan Li, Juan Ge, Russel J. Reiter, Qiang Wang Tags: Original Article Source Type: research
Synergistic effect of melatonin and ghrelin in preventing cisplatin ‐induced ovarian damage via regulation of FOXO3a phosphorylation and binding to the p27Kip1 promoter in primordial follicles
In conclusion, these findings suggest that melatonin and ghrelin co‐administration is suitable for use as a fertoprotective adjuvant therapy during cisplatin chemotherapy in young female cancer patients.
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - June 28, 2017 Category: Research Authors: Hoon Jang, Younghwa Na, Kwonho Hong, Sangho Lee, Sohyeon Moon, Minha Cho, Miseon Park, Ok ‐Hee Lee, Eun Mi Chang, Dong Ryul Lee, Jung Jae Ko, Woo Sik Lee, Youngsok Choi Tags: Original Article Source Type: research
Melatonin protects bone marrow mesenchymal stem cells against iron overload ‐induced aberrant differentiation and senescence
Abstract
Bone marrow mesenchymal stem cells (BMSCs) are an expandable population of stem cells which can differentiate into osteoblasts, chondrocytes and adipocytes. Dysfunction of BMSCs in response to pathological stimuli contributes to bone diseases. Melatonin, a hormone secreted from pineal gland, has been proved to be an important mediator in bone formation and mineralization. The aim of this study was to investigate whether melatonin protected against iron overload‐induced dysfunction of BMSCs and its underlying mechanisms. Here, we found that iron overload induced by ferric ammonium citrate (FAC) caused irregularly...
Source: Journal of Pineal Research - June 20, 2017 Category: Research Authors: Fan Yang, Lei Yang, Yuan Li, Gege Yan, Chao Feng, Tianyi Liu, Rui Gong, Ye Yuan, Ning Wang, Elina Idiiatullina, Timur Bikkuzin, Valentin Pavlov, Yang Li, Chaorun Dong, Dawei Wang, Yang Cao, Zhenbo Han, Lai Zhang, Qi Huang, Fengzhi Ding, Zhengang Bi, Benzh Tags: ORIGINAL ARTICLE Source Type: research
Regulation of bone mass through pineal ‐derived melatonin‐MT2 receptor pathway
Abstract
Tryptophan, an essential amino acid through a series of enzymatic reactions gives rise to various metabolites, viz. serotonin and melatonin, that regulate distinct biological functions. We show here that tryptophan metabolism in the pineal gland favors bone mass accrual through production of melatonin, a pineal‐derived neurohormone. Pineal gland‐specific deletion of Tph1, the enzyme that catalyzes the first step in the melatonin biosynthesis lead to a decrease in melatonin levels and a low bone mass due to an isolated decrease in bone formation while bone resorption parameters remained unaffected. Skeletal ana...
Source: Journal of Pineal Research - June 20, 2017 Category: Research Authors: Kunal Sharan, Kirsty Lewis, Takahisa Furukawa, Vijay K. Yadav Tags: ORIGINAL ARTICLE Source Type: research
Melatonin delays photoreceptor degeneration in a mouse model of autosomal recessive retinitis pigmentosa
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - June 5, 2017 Category: Research Authors: Xiao ‐Jian Xu, Shu‐Min Wang, Ying Jin, Yun‐Tao Hu, Kang Feng, Zhi‐Zhong Ma Tags: Original Article Source Type: research
Enhancement of high glucose ‐induced PINK1 expression by melatonin stimulates neuronal cell survival: Involvement of MT2/Akt/NF‐κB pathway
In conclusion, we have demonstrated the melatonin stimulates PINK1 expression via an MT2/Akt/NF‐κB pathway, and such stimulation is important for the prevention of neuronal cell apoptosis under high glucose conditions.
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - June 5, 2017 Category: Research Authors: Xaykham Onphachanh, Hyun Jik Lee, Jae Ryong Lim, Young Hyun Jung, Jun Sung Kim, Chang Woo Chae, Sei ‐jung Lee, Amr Ahmed Gabr, Ho Jae Han Tags: Original Article Source Type: research
Regulation of bone mass through pineal ‐derived melatonin‐MT2 pathway
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - May 17, 2017 Category: Research Authors: Kunal Sharan, Kirsty Lewis, Takahisa Furukawa, Vijay K. Yadav Tags: Original Article Source Type: research
Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3 ‐dependent regulation of oxidative stress and apoptosis
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - May 13, 2017 Category: Research Authors: Mengen Zhai, Buying Li, Weixun Duan, Lin Jing, Bin Zhang, Meng Zhang, Liming Yu, Zhenhua Liu, Bo Yu, Kai Ren, Erhe Gao, Yang Yang, Hongliang Liang, Zhenxiao Jin, Shiqiang Yu Tags: Original Article Source Type: research
Melatonin inhibits neuronal dysfunction ‐associated with neuroinflammation by atopic psychological stress in NC/Nga atopic‐like mouse models
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - May 13, 2017 Category: Research Authors: Gunhyuk Park, Seung Hoon Lee, Dal ‐Seok Oh, Yong‐ung Kim Tags: Original Article Source Type: research
The role of melatonin in the neurodevelopmental etiology of schizophrenia: A study in human olfactory neuronal precursors
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - May 13, 2017 Category: Research Authors: Tania Galv án‐Arrieta, Citlali Trueta, Montserrat G. Cercós, Marcela Valdés‐Tovar, Salvador Alarcón, Julian Oikawa, Horacio Zamudio‐Meza, Gloria Benítez‐King Tags: Original Article Source Type: research
Melatonin Successfully Rescues Hippocampal Bioenergetics and Improves Cognitive Function following Drug Intoxication by Promoting Nrf2 ‐ARE Signaling Activity
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - May 8, 2017 Category: Research Authors: Li ‐You Chen, Ting‐Yi Renn, Wen‐Chieh Liao, Fu‐Der Mai, Ying‐Jui Ho, George Hsiao, Ai‐Wei Lee, Hung‐Ming Chang Tags: Original Article Source Type: research
The role and therapeutic potential of melatonin in age ‐related ocular diseases
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - May 1, 2017 Category: Research Authors: Almudena Crooke, Fernando Huete ‐Toral, Basilio Colligris, Jesús Pintor Tags: Review Source Type: research
