Melatonin impedes Tet1 ‐dependent mGluR5 promoter demethylation to relieve pain

In conclusion, melatonin relieves pain by impeding Tet1‐dependent demethylation of mGluR5 in dorsal horn neurons through the MT2 receptor. Our findings link melatonin/MT2 signaling to Tet1‐dependent epigenetic demethylation of nociceptive genes for the first time and suggest melatonin as a promising therapy for the treatment of pain. This article is protected by copyright. All rights reserved.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fjpi.12436

Source: Journal of Pineal Research - July 18, 2017 Category: Research Authors: Ming ‐Chun Hsieh, Yu‐Cheng Ho, Cheng‐Yuan Lai, Dylan Chou, Hsueh‐Hsiao Wang, Gin‐Den Chen, Tzer‐Bin Lin, Hsien‐Yu Peng Tags: Original Article Source Type: research