Melatonin attenuates neuronal apoptosis through up ‐regulation of K+–Cl− cotransporter KCC2 expression following traumatic brain injury in rats

In conclusion, our findings suggested that melatonin restores KCC2 expression, inhibits neuronal apoptosis and attenuates secondary brain injury after TBI, partially through activation of BDNF/ERK pathway.

Source: Journal of Pineal Research - June 12, 2016 Category: Research Authors: Haijian Wu, Anwen Shao, Mingfei Zhao, Sheng Chen, Jun Yu, Jingyi Zhou, Feng Liang, Ligen Shi, Brandon J. Dixon, Zhen Wang, Chenhan Ling, Yuan Hong, Jianmin Zhang Tags: Original Article Source Type: research