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Long-term safety of etanercept in psoriasis: Retrospective study focused on infections
Conclusion These data support the good safety profile of etanercept in patients with psoriasis or psoriatic arthritis. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Orsini, D., Narcisi, A., Arcese, A., Costanzo, A. Tags: Immuno-Mediated Diseases And Comorbities Source Type: research

Serological markers associated with disease activity in patients with rheumatoid arthritis treated with rituximab
Conclusions C3 and IgM levels may represent potentially useful serological markers of disease activity during rituximab treatment in patients with RA. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Conigliaro, P., Triggianese, P., Chimenti, M. S., Lucchetti, R., Kroegler, B., Perricone, R. Tags: Immuno-Mediated Diseases and Treatment Immunogenicity Source Type: research

Long-term treatment with adalimumab in psoriatic arthritis: serum adalimumab concentration, immunogenicity and the link with clinical response
Conclusions Serum adalimumab could be an important tool that may improve the management of psoriatic arthritis in patients responding to long-term treatment. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Chimenti, M. S., Triggianese, P., Narcisi, A., Marinari, B., Teoli, M., Faleri, S., Arcese, A., Perricone, R., Costanzo, A. Tags: Immuno-Mediated Diseases and Treatment Immunogenicity Source Type: research

Cardiovascular risk evaluation through heart rate variability analysis in psoriatic patients before and after 24 weeks of etanercept therapy: Prospective study
Conclusion Treatment with etanercept in patients with moderate-to-severe psoriasis could affect cardiovascular autonomic regulation, and subsequently reduce cardiovascular risk. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Potenza, C., Raimondi, G., Pampena, R., Proietti, I., Viola, G. L., Bernardini, N., Tolino, E., Zuber, S., Balduzzi, V., Scordamaglia, B., Skroza, N. Tags: Immuno-Mediated Diseases and Treatment Immunogenicity Source Type: research

How the immune system responds to therapeutic biological agents
This article considers the relative pathogenic mechanisms influencing immunogenicity in biological agents and discusses mechanisms of tolerance and adaptive immune response, including adaptive T-regulatory cell induction and immune response induction. Methods of determining cellular and humoral immune response to biological agents are identified and examined. Assays to detect antidrug antibodies and their isotypes can assist in monitoring immunogenicity and in preventing adverse events. Such strategies also enable resource conservation and may provide regulatory authorities with new insights that can be useful during the p...
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Vultaggio, A., Petroni, G., Pratesi, S., Nencini, F., Cammelli, D., Ferraro, A., Maggi, E., Matucci, A. Tags: Immuno-Mediated Diseases and Treatment Immunogenicity Source Type: research

S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis
Conclusion Both S100A8 and S100A9 may represent good therapeutic targets in psoriasis and psoriatic arthritis. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Chimenti, M. S., Triggianese, P., Botti, E., Narcisi, A., Conigliaro, P., Giunta, A., Teoli, M., Perricone, R., Costanzo, A. Tags: Gene/Molecular Research on Immune-Mediated Diseases Source Type: research

Effective tumour necrosis factor-blocking therapy reduces reactive oxygen metabolite level in rheumatoid arthritis
Conclusion TNF-α inhibition can control disease activity and reduce circulating levels of reactive oxygen species in patients with RA. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Cacciapaglia, F., Grazia Anelli, M., Rizzo, D., Morelli, E., Mazzotta, D., Scioscia, C., Iannone, F., Lapadula, G. Tags: Gene/Molecular Research on Immune-Mediated Diseases Source Type: research

Expression of immunoglobulin-like transcript 4 as an inhibitory receptor in patients with psoriatic arthritis
Conclusion The effect of adalimumab on monocyte surface phenotype may be due to modification of the inflammatory milieu associated with therapy-induced reduction of disease activity in psoriatic arthritis. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Chimenti, M. S., Bergamini, A., Triggianese, P., Guarino, M. D., Gigliucci, G., Conigliaro, P., Perricone, C., Perricone, R. Tags: Gene/Molecular Research on Immune-Mediated Diseases Source Type: research

Synovial fluid from patients with rheumatoid arthritis modulates monocyte cell-surface phenotype
Conclusions Soluble mediators in SF-RA could contribute to modulating inflammation and local effectiveness of the immune response. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Chimenti, M. S., Conigliaro, P., Triggianese, P., Baffari, E., Squillaci, E., Bolacchi, F., Perricone, R., Bergamini, A. Tags: Gene/Molecular Research on Immune-Mediated Diseases Source Type: research

Salivary interleukin-1{beta}: Oral inflammatory biomarker in patients with psoriasis
Conclusion Saliva is a valid noninvasive tool for monitoring inflammation in psoriasis. TNF-α inhibitor treatments appear to interfere with the oral inflammatory process in patients with psoriasis. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Ganzetti, G., Campanati, A., Santarelli, A., Sartini, D., Molinelli, E., Brisigotti, V., Di Ruscio, G., Bobyr, I., Emanuelli, M., Offidani, A. Tags: Gene/Molecular Research on Immune-Mediated Diseases Source Type: research

The effect of etanercept on vascular endothelial growth factor production by cutaneous mesenchymal stem cells from patients with psoriasis
Conclusions Etanercept reduces the production of VEGF in MSCs, which may modulate angiogenesis and contributes towards preventing the start of the "psoriatic march". (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Campanati, A., Orciani, M., Ganzetti, G., Consales, V., Di Primio, R., Offidani, A. Tags: Gene/Molecular Research on Immune-Mediated Diseases Source Type: research

Foreword: Seminars in Research 2014 Joint Experiences in Rheumatology and Dermatology
(Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Costanzo, A., Spinelli, F. R. Tags: Foreword Source Type: research

Epidural blood patch for spontaneous intracranial hypotension with chronic subdural haematoma: A case report and literature review
Spinal leakage of cerebrospinal fluid (CSF) is considered to be the primary cause of spontaneous intracranial hypotension (SIH). Subdural haematoma (SDH) is a serious complication of SIH. This current report presents a case of bilateral SDH with SIH that was treated with epidural blood patching (EBP). A 43-year-old male complained of experiencing orthostatic headaches for 2 months without neurological signs. The patient worsened in a local hospital and was transferred to the Sir Run Run Hospital. Brain computed tomography showed bilateral SDH with a midline shift. The patient underwent emergency trephination in the left fr...
Source: Journal of International Medical Research - July 21, 2016 Category: Research Authors: Zhang, J., Jin, D., Pan, K.-H. Tags: Case Report Source Type: research

Retention during capsule endoscopy: Is it a real problem in routine practice?
Conclusions Scanning patients before CE did not predict capsule retention. Retention is a complication of CE, but occurs as a result of the underlying disease. The risk of retention is increased in patients with motility disorders, suspected small bowel ulcers or malignancies. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - July 21, 2016 Category: Research Authors: Ormeci, A. C., Akyuz, F., Baran, B., Gokturk, S., Ormeci, T., Pinarbasi, B., Mutluay Soyer, O., Evirgen, S., Akyuz, U., Karaca, C., Demir, K., Kaymakoglu, S., Besisik, F. Tags: Clinical Notes Source Type: research

Results of prosthetic rehabilitation on managing transtibial vascular amputation with silicone liner after wound closure
Conclusion A standardized silicone liner programme reduced the duration of rehabilitation and could be a valuable replacement for soft dressing-based stump management. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - July 21, 2016 Category: Research Authors: Chin, T., Toda, M. Tags: Clinical Notes Source Type: research