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Downregulation of miR-154 in human glioma and its clinicopathological and prognostic significance
Conclusions These results suggest that miR-154 downregulation may be involved in glioma formation and progression, and that miR-154 might serve as a potential prognostic biomarker for patients with this disease. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - October 8, 2016 Category: Research Authors: Wang, L., Wu, L., Wu, J. Tags: Research Reports Source Type: research

Laparoendoscopic single-site surgery varicocelectomy versus conventional laparoscopic varicocele ligation: A meta-analysis
Conclusion These data suggest that LESSV offers a well tolerated and efficient alternative to conventional laparoscopic varicocelectomy, with less pain, a shorter recovery time and better cosmetic satisfaction. Further well-designed studies are required to confirm these findings and update the results of this meta-analysis. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - October 8, 2016 Category: Research Authors: Li, M., Wang, Z., Li, H. Tags: Meta-Analysis Source Type: research

Speckled variance optical coherence tomography for the assessment of nail involvement in acrodermatitis continua of Hallopeau: A case study
This study used a multibeam OCT instrument to produce speckled variance OCT (SV-OCT) blood-flow images, which were used to measure the degree of change over successive scans. Nail changes, inflammation and response to therapy were evaluated in a 75-year-old female patient with psoriasis who had severe acrodermatitis continua of Hallopeau of the hands, treated for 4 weeks with 40 mg adalimumab (administered subcutaneously every other week) and 25 mg prednisone (administered orally, daily). SV-OCT provided a detailed assessment of the nail structures in relation to inflammation of psoriatic tissues. Restoration of the normal...
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Conti, A., Ciardo, S., Mandel, V. D., Bigi, L., Pellacani, G. Tags: Real-Life Experiences Source Type: research

The role of methotrexate as combination therapy with etanercept in rheumatoid arthritis: Retrospective analysis of a local registry
Conclusion These data confirm, in a real-life setting, the importance of methotrexate as a combination therapy with etanercept and suggest that the minimal effective dose of methotrexate is >10 mg/week. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Becciolini, A., Biggioggero, M., Favalli, E. G. Tags: Real-Life Experiences Source Type: research

Long-term efficacy of high doses of intravenous immunoglobulins in generalized scleromyxoedema: Case report
Scleromyxoedema is a rare disease with a progressive and disabling course involving dermal deposition of mucin and fibroblast proliferation; it is characterized clinically by a diffuse papular eruption, skin thickening, oedema and decreased skin flexibility, especially of the face and hands. Current therapy options are based on evidence from a limited number of case reports. The clinical manifestations and treatment of a 64-year-old man affected by scleromyxoedema with severe skin involvement of the face, arms and hands, decreased mouth opening and hypomotility of the fingers are reported. Dysphagia, asthenia and immunoglo...
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Arginelli, F., Rongioletti, F., Girolomoni, G., Pellacani, G., Guardoli, D., Conti, A. Tags: Real-Life Experiences Source Type: research

Glomerular filtration rate in patients with psoriasis treated with etanercept
Conclusion EGFR was unaffected by 6 months’ etanercept treatment. Physicians should be aware of the risk of CKD when providing comprehensive care to patients with moderate-to-severe psoriasis. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Gisondi, P., Girolomoni, G. Tags: Real-Life Experiences Source Type: research

Combination therapy with etanercept in psoriasis: Retrospective analysis of efficacy and safety outcomes from real-life practice
Conclusions Short-term comedication in combination with etanercept may optimize treatment options and improve long-term drug survival in patients with psoriasis. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Babino, G., Giunta, A., Ruzzetti, M., Sole Chimenti, M., Chimenti, S., Esposito, M. Tags: Real-Life Experiences Source Type: research

From patients needs to treatment outcomes in psoriasis: Results from the 'pSORRIDI experience
Conclusions Among patients with psoriasis, there may be a need for an improvement in the diagnosis of underlying comorbid conditions, and in disease management of both psoriasis and any comorbid conditions. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Esposito, M., Faleri, S., Babino, G., Messinese, S., Mazzotta, A., Schipani, C., Chimenti, M. S., Marchei, M., Rizza, S., Pandolfi, M., Chimenti, S., Giunta, A. Tags: Real-Life Experiences Source Type: research

Remission and low disease activity in a cohort of real-life patients with rheumatoid arthritis treated with first-line antitumour necrosis factor
Conclusion Remission with first-line anti-TNF treatment is an achievable goal in clinical practice, allowing a reduction in concomitant csDMARD and prednisone treatment. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Conigliaro, P., Chimenti, M. S., Triggianese, P., Ballanti, E., Sunzini, F., Duca, I., Perricone, R. Tags: Real-Life Experiences Source Type: research

Beneficial effects of long-term treatment with bosentan on the development of pulmonary arterial hypertension in patients with systemic sclerosis
Conclusion Long-term treatment with bosentan reduces the risk of developing PAH in patients with systemic sclerosis. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Murdaca, G., Lantieri, F., Puppo, F., Bezante, G. P., Balbi, M. Tags: Immuno-Mediated Diseases and CV Risk Source Type: research

Post-translational modifications in rheumatoid arthritis and atherosclerosis: Focus on citrullination and carbamylation
Coronary heart disease is the main cause of mortality in patients with rheumatoid arthritis (RA), a disease known to be associated with accelerated atherosclerosis. The role of inflammation and immunity in atherosclerotic process offers possible explanations for the increased cardiovascular risk in patients with RA. The immune response to citrullinated peptides has been extensively studied in RA; antibodies directed to citrullinated peptides are now a cornerstone for RA diagnosis. However, few studies have investigated the response to citrullinated peptides and the development of atherosclerotic plaque. Antibodies to carba...
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Spinelli, F. R., Pecani, A., Conti, F., Mancini, R., Alessandri, C., Valesini, G. Tags: Immuno-Mediated Diseases and CV Risk Source Type: research

Asymmetric dimethylarginine and arterial stiffness in patients with rheumatoid arthritis: A case-control study
Conclusions Arterial stiffness appears to be increased in rheumatoid arthritis and independently associated with systemic inflammation and physical disability. ADMA concentration was not increased in this small group of patients with rheumatoid arthritis compared with healthy controls; nor was it associated with arterial stiffness. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Erre, G. L., Piras, A., Mura, S., Mundula, N., Piras, M., Taras, L., Longu, M. G., Saba, P. S., Ganau, A., Carru, C., Passiu, G. Tags: Immuno-Mediated Diseases and CV Risk Source Type: research

Influence of body mass index and weight on etanercept efficacy in patients with psoriasis: A retrospective study
Conclusion Obesity has a negative effect on the efficacy of etanercept in psoriasis. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Giunta, A., Babino, G., Ruzzetti, M., Manetta, S., Chimenti, S., Esposito, M. Tags: Immuno-Mediated Diseases and Obesity Source Type: research

Treatment of psoriasis with etanercept in immunocompromised patients: Two case reports
We report cases of severe plaque psoriasis in a patient with HIV infection and in a liver transplant recipient who were successfully treated with etanercept, an anti-TNF-α agent, without notable side-effects. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: De Simone, C., Perino, F., Caldarola, G., DAgostino, M., Peris, K. Tags: Immuno-Mediated Diseases And Comorbities Source Type: research

Suicide risk and psychiatric comorbidity in patients with psoriasis
Conclusions Patients with psoriasis have an increased risk of psychiatric comorbidities, suicidal ideation, and long-term course of the disease compared with patients who have other dermatological conditions. Psychiatric assessment is highly recommended in patients with psoriasis. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Pompili, M., Innamorati, M., Trovarelli, S., Narcisi, A., Bellini, S., Orsini, D., Forte, A., Erbuto, D., Botti, E., Lamis, D. A., Girardi, P., Costanzo, A. Tags: Immuno-Mediated Diseases And Comorbities Source Type: research