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Clinical significance of CD44s, CD44v3 and CD44v6 in breast cancer
Conclusions CD44s and CD44v6 appear to play opposing roles in the development of breast cancer, but their precise functions and mechanisms of action remain unclear. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - March 16, 2015 Category: Research Authors: Wu, X.-J., Li, X.-D., Zhang, H., Zhang, X., Ning, Z.-H., Yin, Y.-M., Tian, Y. Tags: Original Article Source Type: research

Changes in serum alanine aminotransferase levels in telbivudine versus lamivudine treatment for chronic hepatitis B: A meta-analysis
Conclusion Both LAM and TBV are effective in normalizing ALT levels in patients with CHB, but TBV may be a better choice due to its lower rates of drug resistance. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - March 16, 2015 Category: Research Authors: Dai, M., Xiao, G.-M., Wang, F.-L., Zhang, J.-S., Li, Y.-M., Yang, H.-Z. Tags: Meta-Analysis Source Type: research

Outcome of posterior cruciate ligament reconstruction using the single- versus double bundle technique: A meta-analysis
Conclusions The small amount of data available indicates that double bundle reconstruction is superior to the single bundle technique after isolated PCL injury. These findings should be interpreted with caution due to the low quality and limited sample size of the studies concerned. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - March 16, 2015 Category: Research Authors: Zhao, J.-x., Zhang, L.-h., Mao, Z., Zhang, L.-c., Zhao, Z., Su, X.-y., Zhang, L.-n., Gao, Y., Sun, Y., Tang, P.-f. Tags: Meta-Analysis Source Type: research

Relationship between obesity and sex, and prevalence of asthma-like disease and current wheeze in Han children in Nanjing, China
Conclusions BMI and sex were associated independently with the prevalence of asthma-like disease and current wheeze in Han Chinese children. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - January 30, 2015 Category: Research Authors: Yao, J., Zhou, Y., Wang, J., Wu, H., Liu, H., Shi, Y., Lei, Q., Xia, W., Ji, C., Ye, X., Han, Q., Liang, H., Liu, F., Zhao, D. Tags: Clinical Reports Source Type: research

The effects of motor and intellectual functions on the effectiveness of comprehensive rehabilitation in young children with cerebral palsy
Conclusion There might be a close and reciprocal relationship between the baseline levels of impairment of motor and intellectual function with regard to the effectiveness of CR. Early intervention is important to gain a good outcome in children with CP. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - January 30, 2015 Category: Research Authors: Zhang, H., Zhang, B., Jia, F., Liang, D., Li, H., Chen, Y., Yang, L., Ge, P., Liang, J. Tags: Clinical Reports Source Type: research

Clinical value of repeat blood cultures in neonatal patients receiving antibiotic treatment
Conclusions Repeat blood cultures in neonatal patients who have developed new symptoms >4 days after initial testing may be beneficial. The use of repeat blood culture is not recommended for any other indication. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - January 30, 2015 Category: Research Authors: Al-lawama, M., Badran, E. Tags: Clinical Reports Source Type: research

Relationship between tumour angiogenesis and expression of cyclo-oxygenase-2 and vascular endothelial growth factor-A in human renal cell carcinoma
Conclusion Microvessel density was increased in tumour tissues that expressed COX-2 and VEGF-A, suggesting that COX-2 and VEGF-A are related to tumour angiogenesis in human renal cell carcinoma. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - January 30, 2015 Category: Research Authors: Yang, S., Gao, Q., Jiang, W. Tags: Research Notes Source Type: research

Peripapillary retinal nerve fibre layer thickness in women with iron deficiency anaemia
Conclusion Iron deficiency anaemia reduces RNFL thickness in adult women. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - January 30, 2015 Category: Research Authors: Akdogan, E., Turkyilmaz, K., Ayaz, T., Tufekci, D. Tags: Research Notes Source Type: research

A dissolved oxygen dressing: A pilot study in an ischemic skin flap model
Conclusions Flaps treated with a dissolved oxygen dressing had fewer clinical failures and improved histological profiles compared with control-treated flaps, suggesting that increasing local oxygen supply may improve the local wound healing environment. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - January 30, 2015 Category: Research Authors: Zellner, S., Manabat, R., Roe, D. F. Tags: Research Notes Source Type: research

Magnetic resonance imaging characteristics of hepatocyte apoptosis (induced by right portal vein ligation) and necrosis (induced by combined right portal vein and right hepatic artery ligation) in rats
Conclusions Hepatocyte apoptosis and necrosis induced by ligation procedures exhibited specific changes that were evident on MRI, DWI and MRS, and could be detected in vivo by MRI, in a rat model. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - January 30, 2015 Category: Research Authors: Huang, B., Geng, D., Zhan, S., Li, H., Xu, X., Yi, C. Tags: Research Reports Source Type: research

Effects of diet on adenosine monophosphate-activated protein kinase activity and disease progression in an amyotrophic lateral sclerosis model
Conclusions In this mouse model, increased AMPK activity seems to play a negative role in motor neuron survival, possibly through a novel mechanism involving Hsp70 downregulation. These changes can be modified by diet. Inhibition of AMPK may provide a therapeutic strategy for ALS. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - January 30, 2015 Category: Research Authors: Zhao, Z., Sui, Y., Gao, W., Cai, B., Fan, D. Tags: Research Reports Source Type: research

Burnout: Evaluation of the efficacy and tolerability of TARGET 1(R) for professional fatigue syndrome (burnout)
Conclusions TARGET 1® significantly improved the symptoms of burnout after 12 weeks’ use. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - January 30, 2015 Category: Research Authors: Jacquet, A., Grolleau, A., Jove, J., Lassalle, R., Moore, N. Tags: Research Reports Source Type: research

The impact of the peritoneal glucose load index on hydration status and inflammation in peritoneal dialysis patients
Conclusions PGLI values >3 g/kg/day may be associated with poor glycaemic control, over hydration and augmented inflammation. PGLI might be a useful tool for the quantitative assessment of the PGL and could be applied when managing PD patients. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - January 30, 2015 Category: Research Authors: Hassan, K., Hassan, F., Edgem, R., Moshe, S., Hassan, S. Tags: Research Reports Source Type: research

Myocardial performance is impaired in patients with branch retinal vein occlusion
Conclusion Myocardial performance is decreased in patients with BRVO, independent of whether or not they have hypertension. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - January 30, 2015 Category: Research Authors: Kaderli, B., Kaderli, A. A., Gullulu, S., Inan, U. U., Senturk, T., Aydinlar, A., Yucel, A. A., Avci, R. Tags: Research Reports Source Type: research

Early haemoperfusion with continuous venovenous haemofiltration improves survival of acute paraquat-poisoned patients
Conclusion Combined therapy with HP and CVVH can prevent early death and prolong survival duration following acute paraquat poisoning, providing the opportunity for further treatment. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - January 30, 2015 Category: Research Authors: Gao, Y., Zhang, X., Yang, Y., Li, W. Tags: Research Reports Source Type: research