Effects of diet on adenosine monophosphate-activated protein kinase activity and disease progression in an amyotrophic lateral sclerosis model
Conclusions
In this mouse model, increased AMPK activity seems to play a negative role in motor neuron survival, possibly through a novel mechanism involving Hsp70 downregulation. These changes can be modified by diet. Inhibition of AMPK may provide a therapeutic strategy for ALS.
Source: Journal of International Medical Research - Category: Research Authors: Zhao, Z., Sui, Y., Gao, W., Cai, B., Fan, D. Tags: Research Reports Source Type: research
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