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The efficacy of intrauterine injection of human chorionic gonadotropin before embryo transfer in assisted reproductive cycles: Meta-analysis
Conclusion Women undergoing IVF/ICSI may benefit from intrauterine hCG injection before embryo transfer. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - December 9, 2015 Category: Research Authors: Ye, H., Hu, J., He, W., Zhang, Y., Li, C. Tags: Meta-Analysis Source Type: research

Meta-analysis comparing doublet and single cytotoxic agent therapy as first-line treatment in elderly patients with advanced nonsmall-cell lung cancer
Conclusions Doublet therapy was associated with significantly increased OS, 1-year SR and ORR compared with single agent therapy. Race may be considered when choosing doublet versus single-agent therapy as first-line treatment of NSCLC in elderly patients. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - December 9, 2015 Category: Research Authors: Wang, S., Wang, Q., Tian, J., Zhou, Z., Jiao, L., Fu, Y., Chen, S., Zhang, J., Xu, L. Tags: Meta-Analysis Source Type: research

Identification of a novel de novo GATA3 mutation in a patient with HDR syndrome
We describe the case of a 21-year-old male with hypocalcaemia, hyperphosphataemia, recurrent limb twitch, deafness, proteinuria, increased serum creatinine and urea nitrogen levels, and shrinkage of both kidneys. Brain computed tomography showed intracranial calcifications. The patient was diagnosed with hypoparathyroidism, sensorineural deafness and renal dysplasia (HDR) syndrome. DNA sequence analysis of the GATA3 gene showed a novel de novo mutation, c. 529dupC (p. Arg177profs*126), in exon 2, resulting in a frameshift mutation with a premature stop codon after a new 126 amino acid sequence. We provide further evidence ...
Source: Journal of International Medical Research - September 18, 2015 Category: Research Authors: Chen, L., Chen, B., Leng, W., Lui, X., Wu, Q., Ouyang, X., Liang, Z. Tags: Case Report Source Type: research

Role of high sensitivity C-reactive protein and other risk factors in intracranial and extracranial artery occlusion in patients with ischaemic stroke
Conclusions Coronary heart disease and a history of stroke are risk factors for ischaemic stroke with IEAO. Hs-CRP may be used as a marker for IEAO. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 18, 2015 Category: Research Authors: Xie, D., Deng, L., Liu, X.-d., Li, J.-m., Zhang, Y.-b. Tags: Clinical Reports Source Type: research

Multicentre investigation of pathogenic bacteria and antibiotic resistance genes in Chinese patients with acute exacerbation of chronic obstructive pulmonary disease
Conclusions K. pneumoniae and P. aeruginosa are the most common pathogenic bacteria in AECOPD cases in Beijing, China. Our antibiotic resistance findings may be helpful in selecting antibiotic therapy. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 18, 2015 Category: Research Authors: Ma, X., Cui, J., Wang, J., Chang, Y., Fang, Q., Bai, C., Zhou, X., Zhou, H., Feng, H., Wang, Y., Zhao, W., Wen, Z., Wang, P., Liu, Y., Yu, L., Li, C., Chen, L. Tags: Clinical Reports Source Type: research

Polymorphism rs4263535 in GABRA1 intron 4 was related to deeper sedation by intravenous midazolam
Conclusions Polymorphism rs4263535 in GABRA1 intron 4 was associated with deeper sedation by intravenous midazolam. Patients with the A/A rs4263535 genotype required a smaller dose of midazolam. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 18, 2015 Category: Research Authors: Choi, Y.-J., Lee, S. Y., Yang, K.-S., Park, J.-Y., Yoon, S. Z., Yoon, S. M. Tags: Research Notes Source Type: research

Health anxiety and depression in patients with fibromyalgia syndrome
Conclusions Patients with FMS had significantly higher HAI-SF and BDI scores than healthy controls. Psychiatric support is essential for patients with FMS. Treatment should include biological, psychological and social approaches. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 18, 2015 Category: Research Authors: Ucar, M., Sarp, U., Karaaslan, O., Gul, A. I., Tanik, N., Arik, H. O. Tags: Research Notes Source Type: research

Expression and clinicopathological significance of microRNA-21 and programmed cell death 4 in malignant melanoma
Conclusions These findings suggest that miR-21 and PDCD4 might be potential biomarkers for malignant melanoma and might provide treatment targets in the future. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 18, 2015 Category: Research Authors: Jiao, J., Fan, Y., Zhang, Y. Tags: Research Notes Source Type: research

Prognostic value of neutrophil-to-lymphocyte ratio in pulmonary arterial hypertension
Conclusions NLR was correlated with important prognostic markers in PAH such as NYHA FC, BNP and TAPSE. This simple marker may be useful in the assessment of disease severity in patients with PAH. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 18, 2015 Category: Research Authors: Ozpelit, E., Akdeniz, B., Ozpelit, M. E., Tas, S., Bozkurt, S., Tertemiz, K. C., Sevinc, C., Badak, O. Tags: Research Reports Source Type: research

The effect of extraction angle on endotracheal tube extubation force: Simulation and randomized clinical trial
Conclusion Findings in a manikin simulation were confirmed by those of a randomized clinical trial, where extubation at 60° required less force than 90°, and was accompanied by less SBP elevation. Extubation at 60° is less invasive than extubation at 90°. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 18, 2015 Category: Research Authors: Mihara, R., Komasawa, N., Matsunami, S., Minami, T. Tags: Research Reports Source Type: research

Evaluation of rapid immunochromatographic tests for norovirus in neonatal and infant faecal specimens
Conclusions QN2 offers improved performance and is more useful than QN for the diagnosis of norovirus infection in the neonatal and infant period. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 18, 2015 Category: Research Authors: Takahashi, N., Nojima, I., Araki, T., Takasugi, M., Sakane, T., Kodera, A., Ikeda, M., Tsukahara, H. Tags: Research Reports Source Type: research

Protein microarray with horseradish peroxidase chemiluminescence for quantification of serum {alpha}-fetoprotein
Conclusion Protein microarray is a rapid, simple and low-cost alternative to ELISA for detecting AFP in human serum. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 18, 2015 Category: Research Authors: Zhao, Y., Zhang, Y., Lin, D., Li, K., Yin, C., Liu, X., Jin, B., Sun, L., Liu, J., Zhang, A., Li, N. Tags: Research Reports Source Type: research

Expression of Na+/H+ exchanger regulatory factor 1 in autosomal-dominant polycystic kidney disease
Conclusions ADPKD is associated with a decrease in NHERF1 protein and mRNA levels. Supplementing exogenous NHERF1 inhibited the proliferation of WT9–12 cells. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 18, 2015 Category: Research Authors: Wang, J.-Q., Qin, F., Zhu, L. Tags: Research Reports Source Type: research

Comparison of early recovery and cognitive function after desflurane and sevoflurane anaesthesia in elderly patients: A meta-analysis of randomized controlled trials
Conclusions Desflurane is associated with a faster recovery from general anaesthesia than sevoflurane in elderly patients. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 18, 2015 Category: Research Authors: Chen, G., Zhou, Y., Shi, Q., Zhou, H. Tags: Meta-Analysis Source Type: research

Effect of statins on preventing infectious complications after surgery: Systematic review and meta-analysis
Conclusion Preoperative statin use is associated with a reduced risk of postoperative infectious complications. (Source: Journal of International Medical Research)
Source: Journal of International Medical Research - September 18, 2015 Category: Research Authors: Ma, B.-X., Li, H., Li, J.-S., Wu, S.-S. Tags: Meta-Analysis Source Type: research