How the immune system responds to therapeutic biological agents

This article considers the relative pathogenic mechanisms influencing immunogenicity in biological agents and discusses mechanisms of tolerance and adaptive immune response, including adaptive T-regulatory cell induction and immune response induction. Methods of determining cellular and humoral immune response to biological agents are identified and examined. Assays to detect antidrug antibodies and their isotypes can assist in monitoring immunogenicity and in preventing adverse events. Such strategies also enable resource conservation and may provide regulatory authorities with new insights that can be useful during the process of approving new biological or biosimilar agents.

Source: Journal of International Medical Research - September 27, 2016 Category: Research Authors: Vultaggio, A., Petroni, G., Pratesi, S., Nencini, F., Cammelli, D., Ferraro, A., Maggi, E., Matucci, A. Tags: Immuno-Mediated Diseases and Treatment Immunogenicity Source Type: research