Surgical management of chronic pancreatitis: current utilization in the United States
ConclusionChronic pancreatitis leads to numerous inpatient readmissions, but surgical intervention only occurs in a minority of cases. Complicated patients are more likely to undergo surgery. The complexities of chronic pancreatitis management warrant early multidisciplinary evaluation and ongoing consideration of surgical and non‐surgical options. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 28, 2015 Category: Gastroenterology Authors: Lindsay A. Bliss, Catherine J. Yang, Mariam F. Eskander, Susanna W. L. Geus, Mark P. Callery, Tara S. Kent, A. James Moser, Steven D. Freedman, Jennifer F. Tseng Tags: Original Article Source Type: research

Delayed laparoscopic cholecystectomy increases the total hospital stay compared to an early laparoscopic cholecystectomy after acute cholecystitis: an updated meta‐analysis of randomized controlled trials
ConclusionDLC is associated with a longer total hospital stay but equivalent morbidity as compared to ELC for patients presenting with acute cholecystitis. ELC would appear to be the treatment of choice for patients presenting with ELC. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 27, 2015 Category: Gastroenterology Authors: Benjamin Menahem, Andrea Mulliri, Audrey Fohlen, Lydia Guittet, Arnaud Alves, Jean Lubrano Tags: Review Article: Meta‐Analysis Source Type: research

Distal pancreatectomy with celiac axis resection: what are the added risks?
ConclusionA distal pancreatectomy with celiac axis resection is associated with increased operative time, post‐operative acute kidney injury and a 10% operative mortality. The decision to offer a modified Appleby procedure for a body of pancreas tumour should be made with full disclosure of the increased risks. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 22, 2015 Category: Gastroenterology Authors: Joal D. Beane, Michael G. House, Susan C. Pitt, E. Molly Kilbane, Bruce L. Hall, Abishek D. Parmar, Taylor S. Riall, Henry A. Pitt Tags: Original Article Source Type: research

Conference Calendar
(Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 14, 2015 Category: Gastroenterology Tags: Conference Calendar Source Type: research

Metabolic syndrome after a liver transplantation in an Asian population
ConclusionIn conclusion, pre‐LT components of the MS and the use of certain immunosuppressants are related to developing post‐LTMS. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 14, 2015 Category: Gastroenterology Authors: Hwee Leong Tan, Kieron B. L. Lim, Shridhar Ganpathi Iyer, Stephen K. Y. Chang, Krishnakumar Madhavan, Alfred W. C. Kow Tags: Original Article Source Type: research

Safety and efficacy of transarterial chemoembolization in patients with transjugular intrahepatic portosystemic shunts
ConclusionTACE is an effective treatment strategy for HCC in TIPS patients; albeit may be associated with higher complication rates. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 14, 2015 Category: Gastroenterology Authors: John T. Miura, William S. Rilling, Sarah B. White, Robert A. Hieb, Sean M. Tutton, Parag J. Patel, T. Clark Gamblin, Eric J. Hohenwalter Tags: Original Article Source Type: research

Hilar Cholangiocarcinoma: expert consensus statement
Abstract An American Hepato‐Pancreato‐Biliary Association (AHPBA)‐sponsored consensus meeting of expert panellists met on 15 January 2014 to review current evidence on the management of hilar cholangiocarcinoma in order to establish practice guidelines and to agree consensus statements. It was established that the treatment of patients with hilar cholangiocarcinoma requires a coordinated, multidisciplinary approach to optimize the chances for both durable survival and effective palliation. An adequate diagnostic and staging work‐up includes high‐quality cross‐sectional imaging; however, pathologic confirmation ...
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 14, 2015 Category: Gastroenterology Authors: John C. Mansour, Thomas A. Aloia, Christopher H. Crane, Julie K. Heimbach, Masato Nagino, Jean‐Nicolas Vauthey Tags: Original Article Source Type: research

Gallbladder Cancer: expert consensus statement
Abstract An American Hepato‐Pancreato‐Biliary Association (AHPBA)‐sponsored consensus meeting of expert panellists was convened on 15 January 2014 to review current evidence on the management of gallbladder carcinoma in order to establish practice guidelines. In summary, within high incidence areas, the assessment of routine gallbladder specimens should include the microscopic evaluation of a minimum of three sections and the cystic duct margin; specimens with dysplasia or proven cancer should be extensively sampled. Provided the patient is medically fit for surgery, data support the resection of all gallbladder poly...
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 14, 2015 Category: Gastroenterology Authors: Thomas A. Aloia, Nicolas Járufe, Milind Javle, Shishir K. Maithel, Juan C. Roa, Volkan Adsay, Felipe J. F. Coimbra, William R. Jarnagin Tags: Original Article Source Type: research

Intrahepatic Cholangiocarcinoma: expert consensus statement
Abstract An American Hepato‐Pancreato‐Biliary Association (AHPBA)‐sponsored consensus meeting of expert panellists met on 15 January 2014 to review current evidence on the management of intrahepatic cholangiocarcinoma (ICC) in order to establish practice guidelines and to agree on consensus statements. The treatment of ICC requires a coordinated, multidisciplinary approach to optimize survival. Biopsy is not necessary if the surgeon suspects ICC and is planning curative resection, although biopsy should be obtained before systemic or locoregional therapies are initiated. Assessment of resectability is best accomplish...
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 14, 2015 Category: Gastroenterology Authors: Sharon M. Weber, Dario Ribero, Eileen M. O'Reilly, Norihiro Kokudo, Masaru Miyazaki, Timothy M. Pawlik Tags: Original Article Source Type: research

Consensus Conference on Hilar Cholangiocarcinoma
(Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 14, 2015 Category: Gastroenterology Authors: Christopher E. Forsmark, Alessandro L. Diniz, Andrew X. Zhu Tags: Editorial Source Type: research

Consensus Conference on Gallbladder Cancer
(Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 14, 2015 Category: Gastroenterology Authors: Rachna T. Shroff, Jennifer Knox, Elijah Dixon Tags: Editorial Source Type: research

Consensus Conference on Intrahepatic Cholangiocarcinoma
(Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 14, 2015 Category: Gastroenterology Authors: Ghassan K. Abou‐Alfa, Jean‐François Geschwind, Michael Choti, Michael I. d'Angelica Tags: Editorial Source Type: research

Highlights in this issue
(Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 14, 2015 Category: Gastroenterology Tags: Highlights in this issue Source Type: research

The adequacy of Hepato‐Pancreato‐Biliary training: how closely do perceptions of fellows and programme directors align?
ConclusionsThis study provides insight into content domains that may require additional attention to achieve an appropriate level of proficiency and confidence upon completion of training. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 1, 2015 Category: Gastroenterology Authors: Alexsander K. Bressan, Janet P. Edwards, Sean C. Grondin, Elijah Dixon, Rebecca M. Minter, D. Rohan Jeyarajah, Chad G. Ball Tags: Original Article Source Type: research

Glycogen synthase kinase‐3 inhibitor AR‐A014418 suppresses pancreatic cancer cell growth via inhibition of GSK‐3‐mediated Notch1 expression
ConclusionsThis study demonstrates for the first time that the growth suppressive effect of AR‐A014418 on pancreatic cancer cells is mainly mediated by a reduction in phosphorylation of GSK‐3α with concomitant Notch1 reduction. GSK‐3α appears to stabilize Notch1 by binding and may represent a target for therapeutic development. Furthermore, downregulation of GSK‐3 and Notch1 may be a viable strategy for possible chemosensitization of pancreatic cancer cells to standard therapeutics. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 1, 2015 Category: Gastroenterology Authors: Selvi Kunnimalaiyaan, T. Clark Gamblin, Muthusamy Kunnimalaiyaan Tags: Original Article Source Type: research