Issue Information
(Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - October 22, 2013 Category: Microbiology Tags: Issue Information Source Type: research

Plasmid mediated transformation tropism of chlamydial biovars
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - October 22, 2013 Category: Microbiology Authors: Lihua Song, John H. Carlson, Bing Zhou, Kimmo Virtaneva, William M. Whitmire, Gail L. Sturdevant, Stephen F. Porcella, Grant McClarty, Harlan D. Caldwell Tags: Short Communication Source Type: research

Gallium Induces the Production of Virulence Factors in Pseudomonas aeruginosa
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - October 22, 2013 Category: Microbiology Authors: Rodolfo García‐Contreras, Berenice Pérez‐Eretza, Elizabeth Lira‐Silva, Ricardo Jasso‐Chávez, Rafael Coria‐Jiménez, Adrián Rangel‐Vega, Toshinari Maeda, Thomas K. Wood Tags: Short Communication Source Type: research

Functional dissection of protein domains involved in the immunomodulatory properties of PE_PGRS33 of Mycobacterium tuberculosis
In this study, PE_PGRS33 and its functional deletion mutants were expressed in M. smegmatis, and in vitro and in vivo assays were used to dissect the protein domains involved in the immunomodulatory properties of the protein. We demonstrate that PE_PGRS33‐mediated secretion of TNF‐α by macrophages occurs by extracellular interaction with TLR2. Our results also show that while the PGRS domain of the protein is required for triggering TNF‐α secretion, mutation in the PE domain affects the pro‐inflammatory properties of the protein. These results indicate that PE_PGRS33 is a protein with immunomodulatory activity a...
Source: FEMS Immunology and Medical Microbiology - October 7, 2013 Category: Microbiology Authors: Antonella Zumbo, Ivana Palucci, Alessandro Cascioferro, Michela Sali, Marcello Ventura, Pamela D'Alfonso, Raffaella Iantomasi, Gabriele Di Sante, Francesco Ria, Maurizio Sanguinetti, Giovanni Fadda, Riccardo Manganelli, Giovanni Delogu Tags: Research Article Source Type: research

The presence of antibiotic‐resistant nosocomial pathogens in endotracheal tube biofilms and corresponding surveillance cultures
In this study, we compare the presence of a number of antibiotic‐resistant nosocomial bacteria (Enterobacter aerogenes, Escherichia coli, Micrococcus luteus, Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis) and of Candida albicans in cultures from ET biofilms and SC (i.e. sputum samples, nose swabs, and throat swabs) of 20 mechanically ventilated patients. Our data indicate that there is a good correlation between the presence of (antibiotic‐resistant) pathogens in ET biofilms and SC. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - October 7, 2013 Category: Microbiology Authors: Ilse Vandecandelaere, Nele Matthijs, Hans J. Nelis, Pieter Depuydt, Tom Coenye Tags: Research Article Source Type: research

Identification and characterization of a novel inhibitor of alginate overproduction in Pseudomonas aeruginosa
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - October 1, 2013 Category: Microbiology Authors: T. Ryan Withers, Yeshi Yin, Hongwei D. Yu Tags: Short Communication Source Type: research

Mass spectrometry based proteomic analysis of Leishmania donovani soluble proteins in Indian clinical isolate
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - October 1, 2013 Category: Microbiology Authors: Awanish Kumar, Pragya Misra, Brijesh Sisodia, Ajit Kumar Shasany, Shyam Sundar, Anuradha Dube Tags: Short Communication Source Type: research

Presence of antibiotic resistant nosocomial pathogens in endotracheal tube biofilms and corresponding surveillance cultures
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - September 23, 2013 Category: Microbiology Authors: Ilse Vandecandelaere, Nele Matthijs, Hans J. Nelis, Pieter Depuydt, Tom Coenye Tags: Original Article Source Type: research

Staphylococcus aureus nasal isolates from healthy individuals cause highly variable host cell responses in vitro
This study included five isolates with the most common spa types and five isolates with rare spa types from healthy population. Selected phenotypic traits and genomic content among nasal S. aureus isolates were compared. Besides the rather similar growth rates, our data revealed a high diversity among isolates; i.e. in biofilm formation, ability to attach to and internalize in keratinocytes as well as ability to induce pro‐ and anti‐inflammatory cytokines. The results showed that S. aureus isolates from healthy hosts are phenotypically diverse and causes highly variable host cell responses. Therefore, generalizing the ...
Source: FEMS Immunology and Medical Microbiology - September 21, 2013 Category: Microbiology Authors: Fatemeh Askarian, Maria Sangvik, Anne‐Merethe Hanssen, Lars Snipen, Johanna U. E. Sollid, Mona Johannessen Tags: Research Paper Source Type: research

Issue Information
(Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - September 17, 2013 Category: Microbiology Tags: Issue Information Source Type: research

Functional dissection of protein domains involved in the immune‐modulatory properties of PE_PGRS33 of Mycobacterium tuberculosis
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - September 14, 2013 Category: Microbiology Authors: Antonella Zumbo, Ivana Palucci, Alessandro Cascioferro, Michela Sali, Marcello Ventura, Pamela D'Alfonso, Raffaella Iantomasi, Gabriele Di Sante, Francesco Ria, Maurizio Sanguinetti, Giovanni Fadda, Riccardo Manganelli, Giovanni Delogu Tags: Research Paper Source Type: research

A synthetic lymph node containing inactivated Treponema pallidum cells elicits strong, antigen‐specific humoral and cellular immune responses in mice
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - September 14, 2013 Category: Microbiology Authors: Lola V. Stamm, Rebecca L. Drapp Tags: Research Paper Source Type: research

Issue Information
(Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - September 12, 2013 Category: Microbiology Tags: Issue Information Source Type: research

Helminths and their implication in sepsis – a new branch of their immunomodulatory behaviour?
Abstract The prevalence of autoimmune and allergic disorders has dramatically increased in developed countries, and it is believed that our ‘cleaner living’ reduces exposure to certain microorganisms and leads to deviated and/or reduced regulation of the immune system. In substantiation of this health hygiene hypothesis, multiple epidemiological studies and animal models have characterized the protective immune responses induced by helminths during auto‐inflammatory disorders. The beneficial effects of such helminths, like schistosomes and filariae, are thought to lie in their immunomodulatory capacity, which can be ...
Source: FEMS Immunology and Medical Microbiology - September 10, 2013 Category: Microbiology Authors: Marc P. Hübner, Laura E. Layland, Achim Hoerauf Tags: MiniReview Source Type: research

Mycobacterium tuberculosis escapes from the phagosomes of infected human osteoclasts reprograms osteoclast development via dysregulation of cytokines and chemokines
In this study, we investigated the inflammatory responses of human multinucleated osteoclasts infected with virulent Mtb strain. We found that the intracellular Mtb infection of multinuclear osteoclasts resulted in the rapid growth of Mtb and an osteolytic response, rather than inflammation. In response to Mtb infection, the mononuclear osteoclast precursors produced proinflammatory cytokines including tumor necrosis factor (TNF)‐α, an intrinsic characteristic they share with macrophages. In contrast, highly fused multinucleated osteoclasts incapacitated the production of these cytokines. Instead, the intracellular Mtb ...
Source: FEMS Immunology and Medical Microbiology - September 10, 2013 Category: Microbiology Authors: Akiyoshi Hoshino, Sanshiro Hanada, Hiroyuki Yamada, Shinji Mii, Masahide Takahashi, Satoshi Mitarai, Kenji Yamamoto, Yoshinobu Manome Tags: Research Article Source Type: research