The genetic basis of plasmid tropism between Chlamydia trachomatis and Chlamydia muridarum
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - March 1, 2014 Category: Microbiology Authors: Yibing Wang, Lesley T. Cutcliffe, Rachel J. Skilton, Kyle H. Ramsey, Nicholas R. Thomson, Ian N. Clarke Tags: Short Communication Source Type: research

A putative de‐N‐acetylase of the PIG‐L superfamily affects fluoroquinolone tolerance in Pseudomonas aeruginosa
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - March 1, 2014 Category: Microbiology Authors: Veerle Liebens, Valerie Defraine, Annelies Leyden, Valerie N. Groote, Carolina Fierro, Serge Beullens, Natalie Verstraeten, Cyrielle Kint, Ann Jans, Emanuela Frangipani, Paolo Visca, Kathleen Marchal, Wim Versées, Maarten Fauvart, Jan Michiels Tags: Research Paper Source Type: research

Oral immunization with recombinant Lactococcus lactis delivering a multi‐epitope antigen CTB‐UE attenuates Helicobacter pylori infection in mice
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - March 1, 2014 Category: Microbiology Authors: Xinyang Li, Yingying Xing, Le Guo, Xiaobo Lv, Hui Song, Tao Xi Tags: Research Paper Source Type: research

The deletion of TonB‐dependent receptor genes is part of the genome reduction process that occurs during adaptation of Pseudomonas aeruginosa to the cystic fibrosis lung
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - March 1, 2014 Category: Microbiology Authors: Jozef Dingemans, Lumeng Ye, Falk Hildebrand, Francesca Tontodonati, Michael Craggs, Florence Bilocq, Daniel Vos, Aurélie Crabbé, Rob Houdt, Anne Malfroot, Pierre Cornelis Tags: Research Paper Source Type: research

The carrying pigeons of the cell: exosomes and their role in infectious diseases caused by human pathogens
Abstract Exosomes have recently been classified as the newest family members of ‘bioactive vesicles’ that function to promote intercellular communication. Long ignored and thought to be only a mechanism by which cellular waste is removed, exosomes have garnered a huge amount of interest in recent years as their critical functions in maintaining homeostasis through intercellular communication and also in different types of diseases have been demonstrated. Many groundbreaking studies of exosome functions have been performed in the cancer field and the infectious disease areas of study, revealing the importance and also t...
Source: FEMS Immunology and Medical Microbiology - February 24, 2014 Category: Microbiology Authors: Adam Fleming, Gavin Sampey, Myung‐Chul Chung, Charles Bailey, Monique L. Hoek, Fatah Kashanchi, Ramin M. Hakami Tags: MiniReview Source Type: research

Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2‐aminoimidazole‐based small molecules
Abstract The expression of phenotypic drug resistance or drug tolerance serves as a strategy for Mycobacterium tuberculosis to survive in vivo antimicrobial drug treatment; however, the mechanisms are poorly understood. Progress toward a more in depth understanding of in vivo drug tolerance and the discovery of new therapeutic strategies designed specifically to treat drug‐tolerant M. tuberculosis are hampered by the lack of appropriate in vitro assays. A library of 2‐aminoimidazole‐based small molecules combined with the antituberculosis drug isoniazid was screened against M. tuberculosis expressing in vitro drug ...
Source: FEMS Immunology and Medical Microbiology - February 24, 2014 Category: Microbiology Authors: David F. Ackart, Erick A. Lindsey, Brendan K. Podell, Roberta J. Melander, Randall J. Basaraba, Christian Melander Tags: Research Article Source Type: research

Toxin–Antitoxin systems: their role in persistence, biofilm formation, and pathogenicity
Abstract One of the most pertinent recent outcomes of molecular microbiology efforts to understand bacterial behavior is the discovery of a wide range of toxin–antitoxin (TA) systems that are tightly controlling bacterial persistence. While TA systems were originally linked to control over the genetic material, for example plasmid maintenance, it is now clear that they are involved in essential cellular processes like replication, gene expression, and cell wall synthesis. Toxin activity is induced stochastically or after environmental stimuli, resulting in silencing of the above‐mentioned biological processes and entry...
Source: FEMS Immunology and Medical Microbiology - February 24, 2014 Category: Microbiology Authors: Yurong Wen, Ester Behiels, Bart Devreese Tags: MiniReview Source Type: research

HspX vaccination and role in virulence in the guinea pig model of tuberculosis
In this report, three HspX formulas (native and two recombinant variants) were used as vaccines in the guinea pig model of tuberculosis; none were protective during challenge with WT Mtb. However, recombinant HspX was protective in animals challenged with a strain of Mtb lacking hspX (X4‐19), indicating protection was driven by molecules co‐purifying with HspX or an adjuvant effect of recombinant HspX in this system. Mtb X4‐19 was significantly less virulent than WT Mtb. Quantitative PCR and whole genome sequencing identified several genes (Rv2030c‐Rv2032, Rv1062, Rv1771, Rv1907, and Rv3479) with altered expression...
Source: FEMS Immunology and Medical Microbiology - February 24, 2014 Category: Microbiology Authors: Agatha E. Wieczorek, Jolynn L. Troudt, Phillip Knabenbauer, Jennifer Taylor, Rebecca L. Pavlicek, Russell Karls, Anne Hess, Rebecca M. Davidson, Michael Strong, Helle Bielefeldt‐Ohmann, Angelo A. Izzo, Karen M. Dobos Tags: Research Article Source Type: research

Identification, immunogenicity, and cross‐reactivity of type IV pilin and pilin‐like proteins from Clostridium difficile
We describe nine pilin or pilin‐like protein genes, for which we introduce a coherent nomenclature, in the C. difficile R20291 genome. The nine predicted pilin or pilin‐like proteins have relatively conserved N‐terminal hydrophobic regions, but diverge at their C‐termini. Analysis of synonymous and nonsynonymous substitutions revealed evidence of diversifying selective pressure in two pilin genes. Six of the nine identified proteins were purified and used to immunize mice. Immunization of mice with each individual protein generated antibody responses that varied in titer and cross‐reactivity, a notable result gi...
Source: FEMS Immunology and Medical Microbiology - February 18, 2014 Category: Microbiology Authors: Grace A. Maldarelli, Leon Masi, Erik C. Rosenvinge, Mihaela Carter, Michael S. Donnenberg Tags: Research Article Source Type: research

Temporal expression of agrB, cidA and alsS in the early development of Staphylococcus aureus UAMS‐1 biofilm formation and the structural role of extracellular DNA and carbohydrates
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - February 17, 2014 Category: Microbiology Authors: R. Grande, L. Nistico, K. Sambanthamoorthy, M. Longwell, A. Iannitelli, L. Cellini, A. Di Stefano, L. Hall Stoodley, P. Stoodley Tags: Research Paper Source Type: research

Multiple effects of Escherichia coli Nissle 1917 on growth, biofilm formation and inflammation cytokines profile of Clostridium perfringens type A strain CP4
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - February 16, 2014 Category: Microbiology Authors: Yanlong Jiang, Qingke Kong, Kenneth L. Roland, Amanda Wolf, Roy Curtiss Tags: Research Paper Source Type: research

TLR2 and TLR4 mediate the TNFα response to Vibrio vulnificus biotype 1
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - February 16, 2014 Category: Microbiology Authors: Lola V. Stamm, Rebecca L. Drapp Tags: Short Communication Source Type: research

Antifouling polyurethanes to fight device‐related staphylococcal infections: synthesis, characterization and antibiofilm efficacy
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - February 16, 2014 Category: Microbiology Authors: I. Francolini, G. Donelli, C. Vuotto, F. A. Baroncini, P. Stoodley, V. Taresco, A. Martinelli, L. D'Ilario, A. Piozzi Tags: Research Paper Source Type: research

Importance of biofilm formation and dipeptidyl peptidase IV for the pathogenicity of clinical Porphyromonas gingivalis isolates
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - February 16, 2014 Category: Microbiology Authors: Sofie Clais, Gaëlle Boulet, Monique Kerstens, Tessa Horemans, Wim Teughels, Marc Quirynen, Ellen Lanckacker, Ingrid Meester, Anne‐Marie Lambeir, Peter Delputte, Louis Maes, Paul Cos Tags: Research Paper Source Type: research

Differences in aerosolization of Rift Valley Fever virus resulting from choice of inhalation exposure chamber: implications for animal challenge studies.
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - February 16, 2014 Category: Microbiology Authors: Douglas S. Reed, Laura M. Bethel, Diana S. Powell, Amy L. Caroline, Amy L. Hartman Tags: Research Paper Source Type: research