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Contribution of Fibronectin‐Binding Protein to Pathogenesis of Streptococcus equi ssp. zooepidemicus
Abstract Streptococcus equi ssp. zooepidemicus (S. zooepidemicus) is responsible for a wide variety of infections in many species. Fibronectin‐binding protein is a bacterial cell surface protein, which specifically binds fibronectin (FN). Considering the specific role of FN‐binding protein in host‐pathogen interactions, we investigated the function of a novel FN‐binding domain in the FN‐binding protein (FNZ) of S. zooepidemicus. Five recombinant FNZ gene fragments [N1 (amino acids 38–197), N2 (amino acids 38‐603), N3 (amino acids 41‐315), N4 (amino acids 192‐370) and N5 (amino acids 38‐225)] were expres...
Source: FEMS Immunology and Medical Microbiology - December 1, 2012 Category: Microbiology Authors: Li Yi, Yang Wang, Zhe Ma, Hui Zhang, Yue Li, Jun‐xi Zheng, Yong‐chun Yang, Cheng‐ping Lu, Hong‐jie Fan Tags: Research Paper Source Type: research

Bordetella holmesii: initial genomic analysis of an emerging opportunist
Abstract Bordetella holmesii is an emerging opportunistic pathogen that causes respiratory disease in healthy individuals and invasive infections among patients lacking splenic function. We used 16S rRNA analysis to confirm B. holmesii as the cause of bacteremia in a child with sickle cell disease. Semiconductor‐based draft genome sequencing provided insight into B. holmesii phylogeny and potential virulence mechanisms and also identified a toluene‐4‐monoxygenase locus unique among bordetellae. Bordetella holmesii is a brown pigment‐producing Gram‐negative coccobacillus that is increasingly recognized as a cause ...
Source: FEMS Immunology and Medical Microbiology - December 1, 2012 Category: Microbiology Authors: Paul J. Planet, Apurva Narechania, Saul R. Hymes, Christina Gagliardo, Richard C. Huard, Susan Whittier, Phyllis Della‐Latta, Adam J. Ratner Tags: Short Communication Source Type: research

Pili play an important role in enhancing the bacterial clearance from the middle ear in a mouse model of acute otitis media with Moraxella catarrhalis
In this study, we developed an experimental murine AOM model by inoculating M. catarrhalis in the middle ear bulla and studied the local response to this inoculation, and modulation of its course by the pili of M. catarrhalis. The pili‐positive and pili‐negative M. catarrhalis showed differences in the bacterial clearance and infiltration of inflammatory cells in the middle ear. Pili‐negative M. catarrhalis induces a more delayed and prolonged immune response in the middle ear than that of pili‐positive M. catarrhalis. TLR2, ‐4, ‐5, and ‐9 mRNA expression was upregulated in neutrophils that infiltrated the mi...
Source: FEMS Immunology and Medical Microbiology - December 1, 2012 Category: Microbiology Authors: Toshiaki Kawano, Takashi Hirano, Satoru Kodama, Marcelo Takahiro Mitui, Kamruddin Ahmed, Akira Nishizono, Masashi Suzuki Tags: Research Paper Source Type: research

Colonization of gerbils with Helicobacter pylori O‐chain‐deficient mutant SS1 HP0826::Kan results in gastritis and is associated with de novo synthesis of extended homopolymers
Abstract The O‐chain polysaccharide of Helicobacter pylori is important for colonization and generation of chronic gastritis in mice. There are marked host differences in the development of H. pylori‐induced gastric pathology in mice and gerbils. To investigate the role of the O‐chain polysaccharide of H. pylori in colonization and gastritis in Mongolian gerbils inoculation by oral gavage with H. pylori strain SS1 and its corresponding O‐chain polysaccharide‐deficient mutant SS1 HP0826::Kan was undertaken. Infection with both strains resulted in corpus atrophy, loss of parietal cells and extensive mucous metaplas...
Source: FEMS Immunology and Medical Microbiology - December 1, 2012 Category: Microbiology Authors: Vandana Chandan, Anthony PT Jeremy, Michael F Dixon, Eleonora Altman, Jean E Crabtree Tags: Research Paper Source Type: research

Launching PAD (Pathogens and Disease): More than a new title!
The launch of Pathogens and Disease, which replaces FEMS Immunology and Medical Microbiology, represents much more than a change in title. The journal has been entirely re‐conceived to embrace today's and tomorrow's research in infectious disease biology. In addition to well‐established areas in molecular and cellular pathogenesis, and the host response to infection, Pathogens and Disease will highlight and showcase the role of microbial communities in infectious diseases, the continually expanding impact of systems biology approaches, and the experimental translational applications thereof. © 2013 Federation of Europ...
Source: FEMS Immunology and Medical Microbiology - December 1, 2012 Category: Microbiology Authors: Patrik Bavoil Tags: Editorial Source Type: research

Mannose receptor, C type 1 contributes to bacterial uptake by placental trophoblast giant cells
FEMS Immunology&Medical Microbiology,Volume 66, Issue 3, Page 427-435, December 2012. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - November 16, 2012 Category: Microbiology Source Type: research

Immunogenicity and therapeutic effects of Ag85A/B chimeric DNA vaccine in mice infected with Mycobacterium tuberculosis
FEMS Immunology&Medical Microbiology,Volume 66, Issue 3, Page 419-426, December 2012. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - November 16, 2012 Category: Microbiology Source Type: research

Improved diagnostic power by combined interferon ‐gamma release assay and nested‐PCR in tuberculous pleurisy in high tuberculosis prevalence area
FEMS Immunology&Medical Microbiology,Volume 66, Issue 3, Page 393-398, December 2012. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - November 16, 2012 Category: Microbiology Source Type: research

Alcohol treatment enhances Staphylococcus aureus biofilm development
FEMS Immunology&Medical Microbiology,Volume 66, Issue 3, Page 411-418, December 2012. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - November 16, 2012 Category: Microbiology Source Type: research

Human intestinal epithelial cell ‐derived molecule(s) increase enterohemorrhagic Escherichia coli virulence
FEMS Immunology&Medical Microbiology,Volume 66, Issue 3, Page 399-410, December 2012. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - November 16, 2012 Category: Microbiology Source Type: research

Retraction
FEMS Immunology&Medical Microbiology,Volume 66, Issue 3, Page 449-449, December 2012. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - November 16, 2012 Category: Microbiology Source Type: research

Bill Costerton: leader as servant
FEMS Immunology&Medical Microbiology,Volume 66, Issue 3, Page 269-272, December 2012. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - November 16, 2012 Category: Microbiology Source Type: research

Pluronic P85 enhances the efficacy of outer membrane vesicles as a subunit vaccine against Brucella melitensis challenge in mice
FEMS Immunology&Medical Microbiology,Volume 66, Issue 3, Page 436-444, December 2012. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - November 16, 2012 Category: Microbiology Source Type: research

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FEMS Immunology&Medical Microbiology,Volume 66, Issue 3, Page 427-435, December 2012. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - November 16, 2012 Category: Microbiology Source Type: research

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FEMS Immunology&Medical Microbiology,Volume 66, Issue 3, Page 419-426, December 2012. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - November 16, 2012 Category: Microbiology Source Type: research