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Defective dendritic cell response to toll like receptor 7/8 agonists in perinatally HIV infected children
In conclusion, a majority of perinatally HIV‐infected older children without HAART remain clinically stable in the short term, but have demonstrable immunologic abnormalities indicative of defects in the innate immune system. Children initiated on HAART showed improvement in CD4 counts but didn't show improvement in DC function over the short term. This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - July 19, 2013 Category: Microbiology Authors: Anbalagan Selvaraj, Sudheesh Pilakka Kanthikeel, Bhavani PK, Luke Elizabeth Hanna, Savita Pahwa, Soumya Swaminathan Tags: Research Paper Source Type: research

An oral vaccine against candidiasis generated by yeast molecular display system
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - July 19, 2013 Category: Microbiology Authors: Seiji Shibasaki, Wataru Aoki, Takashi Nomura, Ayuko Miyoshi, Senji Tafuku, Tomomitsu Sewaki, Mitsuyoshi Ueda Tags: Research Paper Source Type: research

Genus‐optimized strategy for the identification of chlamydial type III secretion substrates
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - July 19, 2013 Category: Microbiology Authors: Kelley M. Hovis, Sergio Mojica, Jason E. McDermott, Laura Pedersen, Chana Simhi, Roger G. Rank, Garry S.A. Myers, Jacques Ravel, Ru‐ching Hsia, Patrik M. Bavoil Tags: Research Paper Source Type: research

Early expression of the Type III secretion system of Parachlamydia acanthamoebae during a replicative cycle within its natural host cell Acanthamoeba castellanii
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - July 16, 2013 Category: Microbiology Authors: Antony Croxatto, Valérie Murset, Bérénice Chassot, Gilbert Greub Tags: Research Paper Source Type: research

Analysis of the Staphylococcus aureus abscess proteome identifies antimicrobial host proteins and bacterial stress responses at the host‐pathogen interface
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - July 11, 2013 Category: Microbiology Authors: Ahmed S. Attia, James E. Cassat, Sheg O. Aranmolate, Lisa J. Zimmerman, Kelli L. Boyd, Eric P. Skaar Tags: Research Paper Source Type: research

Antifungal and anticancer effects of a polysaccharide–protein complex from the gut bacterium Raoultella ornithinolytica isolated from the earthworm Dendrobaena veneta
Abstract The polysaccharide–protein complex (PPC) isolated from metabolites of gut bacteria Raoultella ornithinolytica from Dendrobaena veneta earthworms exhibits activity against Candida albicans, in breast ductal carcinoma (line T47D) and in the endometrioid ovarian cancer line (TOV‐112D) in vitro. The action against C. albicans was analyzed using light, SEM, TEM, and AFM microscopes. The changes observed indicated two directions of the action of the complex, that is, disturbance of metabolic activity and cell wall damage. The PPC is an adhesion‐promoting complex inducing death of C. albicans cells by necrosis. O...
Source: FEMS Immunology and Medical Microbiology - July 10, 2013 Category: Microbiology Authors: Marta J. Fiołka, Kinga Lewtak, Jolanta Rzymowska, Krzysztof Grzywnowicz, Monika Hułas‐Stasiak, Weronika Sofińska‐Chmiel, Krzysztof Skrzypiec Tags: Research Article Source Type: research

The role of Serpine‐1 and Tissue inhibitor of metalloproteinase type‐1 in early host responses to Staphylococcus aureus intracutaneous infection of mice
Abstract Staphylococcus aureus is a common cause of skin and soft tissue infections in animal and humans. In the current study, we hypothesized that early host responses to S. aureus infection leading to the recruitment of neutrophils and control of the bacterium at the site of infection depend on the expression of Serpine‐1 and Tissue inhibitor of metalloproteinase type‐1, two important endogenous proteinase inhibitors that possess regulatory properties on a variety of pathophysiological conditions. Using a mouse model of skin infection and single‐gene and double‐gene knockout mice, however, our observations show...
Source: FEMS Immunology and Medical Microbiology - July 8, 2013 Category: Microbiology Authors: Jakob Harslund, Dorte Frees, Páll S. Leifsson, Hanne Offenberg, Maria U. Rømer, Nils Brünner, John E. Olsen Tags: Research Article Source Type: research

Salivary IgA response to probiotic bacteria and mutans streptococci after the use of chewing gum containing Lactobacillus reuteri
Abstract We investigated whether ingestion of probiotic bacteria could influence salivary IgA levels, specific anti‐mutans streptococci IgA levels and specific antibodies towards the ingested probiotic bacterium. The study was a randomised, double‐blind, placebo‐controlled trial, where the test group (n = 11) received twice daily chewing of gum containing Lactobacillus reuteri (2 × 108 CFU per dose) and the control group (n = 12) received placebo. Resting saliva was collected before and after 12 weeks of treatment and 4 weeks after end of treatment. Total salivary IgA concentrations were measured by ELISA. ...
Source: FEMS Immunology and Medical Microbiology - July 2, 2013 Category: Microbiology Authors: Dan Ericson, Kristina Hamberg, Gunilla Bratthall, Gabriela Sinkiewicz‐Enggren, Lennart Ljunggren Tags: Research Article Source Type: research

Hypericum hircinum L. components as new single‐molecule inhibitors of both HIV‐1 reverse transcriptase‐associated DNA polymerase and ribonuclease H activities
In this study, we have tested the ethanolic extracts obtained by the Hypericum hircinum L. (Hypericaceae) growing in Sardinia (Italy) on the HIV‐1 RT‐associated RNase H function and found that they have inhibitory effects. Active extracts were fractionated up to obtain the main components that have been isolated, tested, and identified to be betulinic acid, shikimic acid, chlorogenic acid, quercetin, 5,7,3′,5′‐tetrahydroxyflavanone, and 5,7,3′,5′‐tetrahydroxyflavanone 7‐O‐glucoside. Betulinic acid and 5,7,3′,5′‐tetrahydroxyflavanone 7‐O‐glucoside were active on both RT‐associated activities,...
Source: FEMS Immunology and Medical Microbiology - July 2, 2013 Category: Microbiology Authors: Francesca Esposito, Cinzia Sanna, Claudia Del Vecchio, Valeria Cannas, Alessandro Venditti, Angela Corona, Armandodoriano Bianco, Anna M. Serrilli, Laura Guarcini, Cristina Parolin, Mauro Ballero, Enzo Tramontano Tags: Research Article Source Type: research

Quantitative immunophenotypic analysis of antigen‐presenting cells involved in ectromelia virus antigen presentation in BALB/c and C57BL/6 mice
Abstract During mousepox in resistant (C57BL/6) or susceptible (BALB/c) strains of mice, stimulation of Th1 or Th2 cytokine immune response, respectively, is observed. Because mechanisms of different polarization of T cells remain elusive, in this study, we quantitatively assessed the phenotype of antigen‐presenting cells (APCs) involved in ectromelia virus (ECTV) antigen presentation and cluster formation with effector cells in secondary lymphoid organs of BALB/c and C57BL/6 mice. We showed that both strains of mice display similar dynamics and kinetics of viral antigen presentation by CD11c+, CD11b+, and CD19+ cells. C...
Source: FEMS Immunology and Medical Microbiology - July 2, 2013 Category: Microbiology Authors: Lidia Szulc‐Dąbrowska, Małgorzata Gieryńska, Anna Boratyńska‐Jasińska, Lech Martyniszyn, Anna Winnicka, Marek G. Niemiałtowski Tags: Research Article Source Type: research

Host Organelle Hijackers: A similar modus operandi for Toxoplasma gondii and Chlamydia trachomatis‐Co‐infection model as a tool to investigate pathogenesis –
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - July 2, 2013 Category: Microbiology Authors: Julia D. Romano, Isabelle Coppens Tags: MiniReview Source Type: research

Chlamydia pneumoniae induces expression of proatherogenic factors through activation of the lectin‐like oxidized LDL receptor‐1
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - July 2, 2013 Category: Microbiology Authors: Lee Ann Campbell, Amy W. Lee, Michael E. Rosenfeld, Cho‐chou Kuo Tags: Research Paper Source Type: research

Draft genome sequences of five recent human uropathogenic Escherichia coli isolates
This study reports the release of draft genome sequences of five isolates of uropathogenic Escherichia coli (UPEC), isolated from patients suffering from uncomplicated cystitis in 2012 in Ann Arbor, Michigan. Phylogenetic analyses revealed that these strains belonged to E. coli phylogroups B2 and D, and are closely related to known UPEC strains. Comparative genomic analysis revealed that more conserved proteins were shared between these recent isolates and UPEC strains causing cystitis than those causing pyelonephritis. Additional genomic comparisons identified that three isolates encode a type III secretion system (T3SS) ...
Source: FEMS Immunology and Medical Microbiology - July 2, 2013 Category: Microbiology Authors: Sargurunathan Subashchandrabose, Tracy H. Hazen, David A. Rasko, Harry L. T. Mobley Tags: Short Communication Source Type: research

Co‐infection with Mycobacterium tuberculosis and Human Immunodeficiency Virus: an overview and motivation for systems approaches
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - July 2, 2013 Category: Microbiology Authors: Armin Deffur, Nicola J Mulder, Robert J Wilkinson Tags: MiniReview Source Type: research

Role of Bordetella pertussis RseA in the cell envelope stress response and adenylate cyclase toxin release
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - July 2, 2013 Category: Microbiology Authors: Tomoko Hanawa, Hideo Yonezawa, Hayato Kawakami, Shigeru Kamiya, Sandra K. Armstrong Tags: Research Paper Source Type: research