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Alterations in TLRs as new molecular markers of congenital infections with Human cytomegalovirus?
We report the impact of TLRs on the function of miRNAs and the altered expression levels of these molecules, as observed in HCMV infections. We suggest that the methylation status of TLR gene promoter regions as epigenetic modifications may be significant in the immune response to HCMV infections. We conclude that it is important to study in detail the molecular mechanisms of TLR function in the immune response to HCMV infections in pregnancy. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - September 10, 2013 Category: Microbiology Authors: Wioletta Wujcicka, Jan Wilczyński, Dorota Nowakowska Tags: Minireview Source Type: research

Susceptibility genes are enriched in those of the herpes simplex virus 1/host interactome in psychiatric and neurological disorders
Abstract Herpes simplex virus 1 (HSV‐1) can promote beta‐amyloid deposition and tau phosphorylation, demyelination or cognitive deficits relevant to Alzheimer's disease or multiple sclerosis and to many neuropsychiatric disorders with which it has been implicated. A seroprevalence much higher than disease incidence has called into question any primary causal role. However, as also the case with risk‐promoting polymorphisms (also present in control populations), any causal effects are likely to be conditional. During its life cycle, the virus binds to many proteins and modifies the expression of multiple genes creatin...
Source: FEMS Immunology and Medical Microbiology - September 2, 2013 Category: Microbiology Authors: Chris J. Carter Tags: Research Article Source Type: research

Murine marginal zone B cells play a role in Vibrio cholerae LPS antibody responses
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - August 21, 2013 Category: Microbiology Authors: William F. Wade, R. Glenn King, Cyrille Grandjean, Terri K. Wade, Louis B. Justement Tags: Short Communication Source Type: research

Defective dendritic cell response to Toll‐like receptor 7/8 agonists in perinatally HIV‐infected children
In conclusion, a majority of perinatally HIV‐infected older children without HAART remain clinically stable in the short term, but have demonstrable immunologic abnormalities indicative of defects in the innate immune system. Children initiated on HAART showed improvement in CD4 counts but did not show improvement in DC function over the short term. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - August 19, 2013 Category: Microbiology Authors: Anbalagan Selvaraj, Sudheesh Pilakka‐Kanthikeel, Perumal Kannabiran Bhavani, Luke E. Hanna, Savita Pahwa, Soumya Swaminathan Tags: Research Article Source Type: research

An oral vaccine against candidiasis generated by a yeast molecular display system
Abstract Enolase 1 (Eno1p) of Candida albicans is an immunodominant antigen. However, conventional technologies for preparing an injectable vaccine require purification of the antigenic protein and preparation of an adjuvant. To develop a novel type of oral vaccine against candidiasis, we generated Saccharomyces cerevisiae cells that display the Eno1p antigen on their surfaces. Oral delivery of the engineered S. cerevisiae cells prolonged survival rate of mice that were subsequently challenged with C. albicans. Given that a vaccine produced using molecular display technology avoids the need for protein purification, this...
Source: FEMS Immunology and Medical Microbiology - August 14, 2013 Category: Microbiology Authors: Seiji Shibasaki, Wataru Aoki, Takashi Nomura, Ayuko Miyoshi, Senji Tafuku, Tomomitsu Sewaki, Mitsuyoshi Ueda Tags: Research Article Source Type: research

Identification of a protective protein from stationary‐phase exoproteome of Brucella abortus
Abstract Brucellosis is a worldwide zoonotic disease. No Brucella vaccine is available for use in humans, and existing animal vaccines have limitations. To search the putative vaccine candidates, we studied the exoproteome of Brucella abortus NCTC 10093 using 2‐DE–MS approach. Twenty‐six proteins were identified using MALDI‐TOF/TOF tandem mass spectrometry. Outer membrane protein 25, d‐galactose periplasmic‐binding protein, oligopeptide ABC transporter protein and isopropylmalate synthase were found to be the most abundant proteins. Most proteins (6, 23%) were predicted to be involved in amino acid transport an...
Source: FEMS Immunology and Medical Microbiology - August 14, 2013 Category: Microbiology Authors: Shikha Jain, Subodh Kumar, Sudhir Dohre, Prachiti Afley, Nabonita Sengupta, Syed I. Alam Tags: Research Article Source Type: research

Helminths and their implication in sepsis ‐ a new branch of their immunomodulatory behaviour
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - August 8, 2013 Category: Microbiology Authors: Marc P. Hübner, Laura E. Layland, Achim Hoerauf Tags: MiniReview Source Type: research

Role of the Listeria monocytogenes 2‐Cys peroxiredoxin homologue in protection against oxidative and nitrosative stress and in virulence
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - August 8, 2013 Category: Microbiology Authors: Lone E. Dons, Ahmed Mosa, Martin E. Rottenberg, Jesper T. Rosenkrantz, Krister Kristensson, John E. Olsen Tags: Short Communication Source Type: research

Mycobacterium tuberculosis escapes from the phagosomes of infected human osteoclasts, and reprograms osteoclast development via dysregulation of cytokines and chemokines
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - August 8, 2013 Category: Microbiology Authors: Akiyoshi Hoshino, Sanshiro Hanada, Hiroyuki Yamada, Shinji Mii, Masahide Takahashi, Satoshi Mitarai, Kenji Yamamoto, Yoshinobu Manome Tags: Research Paper Source Type: research

TLRs alterations as new molecular markers of congenital infections with HCMV
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - August 8, 2013 Category: Microbiology Authors: Wioletta Wujcicka, Jan Wilczyński, Dorota Nowakowska Tags: Other Source Type: research

Peptide matching between Epstein–Barr virus and human proteins
We report that numerous EBV peptides of different length (from 10‐ to 13‐mer) are present in 28 human proteins. The viral vs. human peptide overlap mainly involves the glycine‐rich region allocated in the NH2 terminus of Epstein–Barr nuclear antigen 1 protein and host cellular components that play crucial roles in basic biochemical pathways, such as chromatin remodeling, RNA splicing, transmission across chemical/electrical synapses, and neurogenesis, and that, when altered, may characterize various pathologies such as immunodeficiency, systemic lupus erythematosus, myelination, and speech disorders. The present re...
Source: FEMS Immunology and Medical Microbiology - August 6, 2013 Category: Microbiology Authors: Giovanni Capone, Michele Calabrò, Guglielmo Lucchese, Candida Fasano, Bruna Girardi, Lorenzo Polimeno, Darja Kanduc Tags: Short Communication Source Type: research

Haemophilus influenzae and Streptococcus pneumoniae: living together in a biofilm
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Source: FEMS Immunology and Medical Microbiology - August 3, 2013 Category: Microbiology Authors: Alexandra Tikhomirova, Stephen P. Kidd Tags: Mini Review Source Type: research

Pseudomonas aeruginosa‐dependent upregulation of TLR2 influences host responses to a secondary Staphylococcus aureus infection
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - August 3, 2013 Category: Microbiology Authors: Hee‐Sung Shin, Jung‐Hoon Lee, Se‐Hwan Paek, Yong Woo Jung, Un‐Hwan Ha Tags: Research Paper Source Type: research

The RD1 locus in the Mycobacterium tuberculosis genome contributes to the maturation and secretion of IL‐1α from infected macrophages through the elevation of cytoplasmic calcium levels and calpain activation
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - August 3, 2013 Category: Microbiology Authors: Ruili Yang, Chen Xi, Sita R. Dewamitta, Shunsuke Sakai, Kohsuke Tsuchiya, Hideki Hara, Yanna Shen, Huixin Qu, Rendong Fang, Masao Mitsuyama, Ikuo Kawamura Tags: Research Paper Source Type: research

Evaluation of YadC protein delivered by live attenuated Salmonella as a vaccine against plague
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - August 3, 2013 Category: Microbiology Authors: Wei Sun, Joseph Olinzock, Shifeng Wang, Shilpa Sanapala, Roy Curtiss Tags: Research Paper Source Type: research