Staphylococcus aureus nasal isolates from healthy individuals cause highly variable host cell responses in vitro

This study included five isolates with the most common spa types and five isolates with rare spa types from healthy population. Selected phenotypic traits and genomic content among nasal S. aureus isolates were compared. Besides the rather similar growth rates, our data revealed a high diversity among isolates; i.e. in biofilm formation, ability to attach to and internalize in keratinocytes as well as ability to induce pro‐ and anti‐inflammatory cytokines. The results showed that S. aureus isolates from healthy hosts are phenotypically diverse and causes highly variable host cell responses. Therefore, generalizing the results from one S. aureus isolate to all is highly questionable. This article is protected by copyright. All rights reserved.
Source: FEMS Immunology and Medical Microbiology - Category: Microbiology Authors: Tags: Research Paper Source Type: research