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Associations of Age and Sex With Marfan Phenotype: The National Heart, Lung, and Blood Institute GenTAC (Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions) Registry [Original Articles]
Conclusions— Pulmonary, skeletal, and aortic complications, but not other phenotypic features, are more prevalent in adults than children in Marfan syndrome. Aortic aneurysms and prophylactic aortic surgery are more common in men. Aortic dissection, commonly type B, occurs in an appreciable proportion of Marfan patients, especially in men and after previous prophylactic aortic root replacement. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 9, 2017 Category: Cardiology Authors: Roman, M. J., Devereux, R. B., Preiss, L. R., Asch, F. M., Eagle, K. A., Holmes, K. W., LeMaire, S. A., Maslen, C. L., Milewicz, D. M., Morris, S. A., Prakash, S. K., Pyeritz, R. E., Ravekes, W. J., Shohet, R. V., Song, H. K., Weinsaft, J. W., for the Gen Tags: Genetics, Aneurysm, Aortic Dissection Original Articles Source Type: research

Gene Team in Blood Pressure Genetics [Editorials]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - May 15, 2017 Category: Cardiology Authors: Morris, B. J. Tags: Genetic, Association Studies, Functional Genomics, High Blood Pressure, Hypertension Editorials Source Type: research

Familial Analysis of Epistatic and Sex-Dependent Association of Genes of the Renin-Angiotensin-Aldosterone System and Blood Pressure [Original Articles]
Conclusions— SNPs at key renin–angiotensin–aldosterone system genes associate with systolic blood pressure individually in both sexes, individually in one sex only and only when combined with another SNP. Analyses that incorporate sex-dependent and epistatic effects could reconcile past inconsistencies and account for some of the missing heritability of blood pressure and are generally relevant to SNP association studies for any phenotype. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - May 15, 2017 Category: Cardiology Authors: Scurrah, K. J., Lamantia, A., Ellis, J. A., Harrap, S. B. Tags: ACE/Angiotensin Receptors/Renin Angiotensin System, Epidemiology, Genetic, Association Studies, Blood Pressure Original Articles Source Type: research

Use of Clinical Exome Sequencing in Isolated Congenital Heart Disease [Clinical Genomic Cases]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - May 4, 2017 Category: Cardiology Authors: Zahavich, L., Bowdin, S., Mital, S. Tags: Cardiovascular Disease, Genetics Clinical Genomic Cases Source Type: research

Genetics of Congenital Heart Disease: Is the Glass Now Half-Full? [Editorials]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - May 3, 2017 Category: Cardiology Authors: Leatherbury, L., Berul, C. I. Tags: Developmental Biology, Genetic, Association Studies, Congenital Heart Disease Editorials Source Type: research

Genome-Wide Association Studies and Meta-Analyses for Congenital Heart Defects [Original Articles]
Conclusions— We identified 1 novel candidate region associated with LVOTDs and report on several additional regions with suggestive evidence for association with CTD and LVOTD. These studies were constrained by the relatively small samples sizes and thus have limited power to detect small to moderate associations. Approaches that minimize the multiple testing burden (eg, gene or pathway based) may, therefore, be required to uncover common variants contributing to the risk of these relatively rare conditions. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - May 3, 2017 Category: Cardiology Authors: Agopian, A. J., Goldmuntz, E., Hakonarson, H., Sewda, A., Taylor, D., Mitchell, L. E., Pediatric Cardiac Genomics Consortium* Tags: Epidemiology, Genetic, Association Studies, Functional Genomics, Congenital Heart Disease Original Articles Source Type: research

Are Double Mutations Double Trouble? [Editorials]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 18, 2017 Category: Cardiology Authors: Fatkin, D., Johnson, R. Tags: Cardiovascular Disease, Genetics Editorials Source Type: research

Prevalence and Clinical Implication of Double Mutations in Hypertrophic Cardiomyopathy: Revisiting the Gene-Dose Effect [Original Articles]
Conclusions— Double mutations in patients with hypertrophic cardiomyopathy are much less common than previously estimated. With the exception of double radical MYBPC3 mutations, there is little data to guide clinical decision making in cases with double mutations. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 18, 2017 Category: Cardiology Authors: Fourey, D., Care, M., Siminovitch, K. A., Weissler-Snir, A., Hindieh, W., Chan, R. H., Gollob, M. H., Rakowski, H., Adler, A. Tags: Genetics, Cardiomyopathy Original Articles Source Type: research

Correction [Correction]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 18, 2017 Category: Cardiology Tags: Correction Source Type: research

Investigating the Genetic Architecture of the PR Interval Using Clinical Phenotypes [Original Articles]
Conclusions— The genetic architecture of the PR interval comprises modulators of atrial fibrillation risk and obesity. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 17, 2017 Category: Cardiology Authors: Mosley, J. D., Shoemaker, M. B., Wells, Q. S., Darbar, D., Shaffer, C. M., Edwards, T. L., Bastarache, L., McCarty, C. A., Thompson, W., Chute, C. G., Jarvik, G. P., Crosslin, D. R., Larson, E. B., Kullo, I. J., Pacheco, J. A., Peissig, P. L., Brilliant, Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Genetic, Association Studies Original Articles Source Type: research

Socioeconomic Status Interacts with the Genetic Effect of a Chromosome 9p21.3 Common Variant to Influence Coronary Artery Calcification and Incident Coronary Events in the Heinz Nixdorf Recall Study (Risk Factors, Evaluation of Coronary Calcium, and Lifestyle) [Original Articles]
Conclusions— A 9p21.3 common variant seems to interact with SES to influence CAC and incident coronary events in a population-based cohort. This supports the hypothesis that better material, psychosocial, and lifestyle conditions enable higher SES groups to reduce the expression of their genetic susceptibility to coronary artery disease. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 14, 2017 Category: Cardiology Authors: Schmidt, B., Frolich, S., Dragano, N., Frank, M., Eisele, L., Pechlivanis, S., Forstner, A. J., Nothen, M. M., Mahabadi, A. A., Erbel, R., Moebus, S., Jockel, K.-H. Tags: Epidemiology, Lifestyle, Genetic, Association Studies, Atherosclerosis, Coronary Artery Disease Original Articles Source Type: research

Delivering Clinical Grade Sequencing and Genetic Test Interpretation for Cardiovascular Medicine [Advances in Genetics]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 14, 2017 Category: Cardiology Authors: Harper, A. R., Parikh, V. N., Goldfeder, R. L., Caleshu, C., Ashley, E. A. Tags: Sudden Cardiac Death, Cardiovascular Disease, Genetics, Cardiomyopathy Advances in Genetics Source Type: research

Local Ancestry Association, Admixture Mapping, and Ongoing Challenges [Editorials]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 13, 2017 Category: Cardiology Authors: Mani, A. Tags: Genetic, Association Studies, Genetics, Cerebrovascular Disease/Stroke, Ischemic Stroke, Vascular Disease Editorials Source Type: research

Heritability of the Severity of the Metabolic Syndrome in Whites and Blacks in 3 Large Cohorts [Original Articles]
Conclusions— MetS severity seems highly heritable among whites and blacks. This continuous MetS severity Z score may provide a more useful means of characterizing phenotypic MetS in genetic studies by minimizing racial differences. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 13, 2017 Category: Cardiology Authors: Musani, S. K., Martin, L. J., Woo, J. G., Olivier, M., Gurka, M. J., DeBoer, M. D. Tags: Cardiovascular Disease, Epidemiology, Risk Factors Original Articles Source Type: research

Nonfamilial Hypertrophic Cardiomyopathy: Prevalence, Natural History, and Clinical Implications [Original Articles]
Conclusions— Approximately 40% of HCM probands have a nonfamilial subtype, with later onset and less severe clinical course. We propose a revised clinical pathway for management, highlighting the role of genetic testing, a detailed pedigree, and refined clinical surveillance recommendations for family members. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 13, 2017 Category: Cardiology Authors: Ingles, J., Burns, C., Bagnall, R. D., Lam, L., Yeates, L., Sarina, T., Puranik, R., Briffa, T., Atherton, J. J., Driscoll, T., Semsarian, C. Tags: Genetics, Cardiomyopathy, Hypertrophy Original Articles Source Type: research