Familial Analysis of Epistatic and Sex-Dependent Association of Genes of the Renin-Angiotensin-Aldosterone System and Blood Pressure [Original Articles]

Conclusions— SNPs at key renin–angiotensin–aldosterone system genes associate with systolic blood pressure individually in both sexes, individually in one sex only and only when combined with another SNP. Analyses that incorporate sex-dependent and epistatic effects could reconcile past inconsistencies and account for some of the missing heritability of blood pressure and are generally relevant to SNP association studies for any phenotype.

http://circgenetics.ahajournals.org/cgi/content/short/10/3/e001595?rss=1

Source: Circulation: Cardiovascular Genetics - May 15, 2017 Category: Cardiology Authors: Scurrah, K. J., Lamantia, A., Ellis, J. A., Harrap, S. B. Tags: ACE/Angiotensin Receptors/Renin Angiotensin System, Epidemiology, Genetic, Association Studies, Blood Pressure Original Articles Source Type: research