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Admixture Mapping of Subclinical Atherosclerosis and Subsequent Clinical Events Among African Americans in 2 Large Cohort Studies [Original Articles]
Conclusions— We identified several novel LEA regions, in addition to previously identified genetic variations, associated with cCIMT and cardiovascular disease events among African Americans. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 13, 2017 Category: Cardiology Authors: Shendre, A., Wiener, H., Irvin, M. R., Zhi, D., Limdi, N. A., Overton, E. T., Wassel, C. L., Divers, J., Rotter, J. I., Post, W. S., Shrestha, S. Tags: Cardiovascular Disease, Epidemiology, Genetic, Association Studies, Ultrasound, Atherosclerosis Original Articles Source Type: research

Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor [Original Articles]
Conclusions— For common diseases such as VTE, biobanks provide potential to perform genetic discovery, explore the phenotypic consequences for disease-associated variants, and test causal inference. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 3, 2017 Category: Cardiology Authors: Klarin, D., Emdin, C. A., Natarajan, P., Conrad, M. F., the INVENT Consortium, Kathiresan, S. Tags: Genetic, Association Studies, Genetics, Thrombosis Original Articles Source Type: research

Potential Impact and Study Considerations of Metabolomics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association [AHA Scientific Statement]
Through the measure of thousands of small-molecule metabolites in diverse biological systems, metabolomics now offers the potential for new insights into the factors that contribute to complex human diseases such as cardiovascular disease. Targeted metabolomics methods have already identified new molecular markers and metabolomic signatures of cardiovascular disease risk (including branched-chain amino acids, select unsaturated lipid species, and trimethylamine-N-oxide), thus in effect linking diverse exposures such as those from dietary intake and the microbiota with cardiometabolic traits. As technologies for metabolomic...
Source: Circulation: Cardiovascular Genetics - March 30, 2017 Category: Cardiology Authors: Cheng, S., Shah, S. H., Corwin, E. J., Fiehn, O., Fitzgerald, R. L., Gerszten, R. E., Illig, T., Rhee, E. P., Srinivas, P. R., Wang, T. J., Jain, M., on behalf of the American Heart Association Council on Functional Genomics and Translational Biology; Cou Tags: Statements and Guidelines AHA Scientific Statement Source Type: research

Screening of the Filamin C Gene in a Large Cohort of Hypertrophic Cardiomyopathy Patients [Original Article]
Conclusions— We provide a compelling evidence of the involvement of FLNC in the development of HCM. Most of the FLNC variants were associated with mild forms of HCM and a reduced penetrance, with few affected in the families to confirm the segregation. Our work, together with others who found FLNC variants among patients with dilated and restrictive cardiomyopathies, pointed to this gene as an important cause of structural cardiomyopathies. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - March 29, 2017 Category: Cardiology Authors: Gomez, J., Lorca, R., Reguero, J. R., Moris, C., Martin, M., Tranche, S., Alonso, B., Iglesias, S., Alvarez, V., Diaz-Molina, B., Avanzas, P., Coto, E. Tags: Genetics, Hypertrophy Original Article Source Type: research

Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians [Original Article]
Conclusions— We identified 1 novel variant and 1 novel gene and present the first direct evidence of relevance of the KCNK3 locus for LTA BP among East Asians. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - March 27, 2017 Category: Cardiology Authors: Li, C., Kim, Y. K., Dorajoo, R., Li, H., Lee, I.-T., Cheng, C.-Y., He, M., Sheu, W. H.-h., Guo, X., Ganesh, S. K., He, J., Lee, J., Liu, J., Hu, Y., Rao, D. C., Tsai, F.-J., Koh, J. Y., Hu, H., Liang, K.-W., Palmas, W., Hixson, J. E., Han, S., Teo, Y.-Y., Tags: Genetic, Association Studies, High Blood Pressure Original Article Source Type: research

Editorial Board [Editorial Board]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - February 20, 2017 Category: Cardiology Tags: Editorial Board Source Type: research

Ankyrin-B Defects: Serendipity and Inquisitiveness are the Mothers of Invention [Editorials]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - February 13, 2017 Category: Cardiology Authors: Duff, H., Sheldon, R. S. Tags: Electrophysiology, Animal Models of Human Disease, Basic Science Research, Genetically Altered and Transgenic Models, Genetics Editorials Source Type: research

Hyaluronidase 2 Deficiency Causes Increased Mesenchymal Cells, Congenital Heart Defects, and Heart Failure [Original Articles]
Conclusions— These data demonstrate that disruption of normal HA catabolism in Hyal2–/– mice causes increased HA, which may promote endothelial-to-mesenchymal transition and proliferation of mesenchymal cells. Excess endothelial-to-mesenchymal transition, resulting in increased mesenchymal cells, is the likely cause of morphological heart abnormalities in both humans and mice. In mice, these abnormalities result in progressive and severe diastolic dysfunction, culminating in heart failure. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - February 13, 2017 Category: Cardiology Authors: Chowdhury, B., Xiang, B., Liu, M., Hemming, R., Dolinsky, V. W., Triggs-Raine, B. Tags: Basic Science Research, Developmental Biology, Fibrosis, Genetically Altered and Transgenic Models, Heart Failure Original Articles Source Type: research

Novel Variant in the ANK2 Membrane-Binding Domain Is Associated With Ankyrin-B Syndrome and Structural Heart Disease in a First Nations Population With a High Rate of Long QT Syndrome [Original Articles]
Conclusions— We identify the first disease-causing ANK2 variant localized to the membrane-binding domain resulting in reduced ankyrin-B expression and abnormal localization. Further study is warranted on the potential association of this variant with structural heart disease given the role of ANK2 in targeting and stabilization of key structural and signaling molecules in cardiac cells. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - February 13, 2017 Category: Cardiology Authors: Swayne, L. A., Murphy, N. P., Asuri, S., Chen, L., Xu, X., McIntosh, S., Wang, C., Lancione, P. J., Roberts, J. D., Kerr, C., Sanatani, S., Sherwin, E., Kline, C. F., Zhang, M., Mohler, P. J., Arbour, L. T. Tags: Arrhythmias, Cell Biology/Structural Biology, Clinical Studies, Cardiovascular Disease, Genetics Original Articles Source Type: research

Genetic Insurance Discrimination in Sudden Arrhythmia Death Syndromes: Empirical Evidence From a Cross-Sectional Survey in North America [Original Article]
Conclusions— Increased genetic testing has negatively impacted insurability for SADS patients and affected family members. The challenges in obtaining life and health insurance are mainly because of the preexisting condition, even in the presence of protective laws in the United States. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - January 23, 2017 Category: Cardiology Authors: Mohammed, S., Lim, Z., Dean, P. H., Potts, J. E., Tang, J. N. C., Etheridge, S. P., Lara, A., Husband, P., Sherwin, E. D., Ackerman, M. J., Sanatani, S. Tags: Arrhythmias, Electrophysiology, Sudden Cardiac Death, Genetics, Ethics and Policy Original Article Source Type: research

The Long Noncoding RNA Landscape of the Ischemic Human Left Ventricle [Original Articles]
Conclusions— We describe a list of lncRNAs that are differentially expressed after ischemia in the human heart. These genes are predicted to function in pathways consistent with myocardial injury. As a result, lncRNAs may serve as novel diagnostic and therapeutic targets for ischemic heart disease. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00985049. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - January 22, 2017 Category: Cardiology Authors: Saddic, L. A., Sigurdsson, M. I., Chang, T.-W., Mazaika, E., Heydarpour, M., Shernan, S. K., Seidman, C. E., Seidman, J. G., Aranki, S. F., Body, S. C., Muehlschlegel, J. D. Tags: Ischemia, Gene Expression & Regulation, Myocardial Infarction, Cardiovascular Surgery Original Articles Source Type: research

Functional Validation of a Common Nonsynonymous Coding Variant in ZC3HC1 Associated With Protection From Coronary Artery Disease [Original Articles]
Conclusions— These findings extend the genetic association between rs11556924 and coronary artery disease risk by characterizing its effects on the encoded protein, NIPA. The resulting amino acid change Arg363His is associated with increased expression and nuclear mobility, as well as lower rates of cell growth in HeLa cells, further supporting a role for cell proliferation in atherosclerosis and its clinical consequences. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - January 22, 2017 Category: Cardiology Authors: Linseman, T., Soubeyrand, S., Martinuk, A., Nikpay, M., Lau, P., McPherson, R. Tags: Mechanisms, Cardiovascular Disease, Genetic, Association Studies, Functional Genomics, Coronary Artery Disease Original Articles Source Type: research

Genome-Wide Prioritization and Transcriptomics Reveal Novel Signatures Associated With Thiazide Diuretics Blood Pressure Response [Original Articles]
Conclusions— This study highlights the strength of using different omics to identify novel biomarkers of drug response and suggests VASP as a potential determinant of thiazide diuretics BP response. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifiers: NCT00246519 and NCT01203852. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - January 22, 2017 Category: Cardiology Authors: Shahin, M. H., Sa, A. C., Webb, A., Gong, Y., Langaee, T., McDonough, C. W., Riva, A., Beitleshees, A. L., Chapman, A. B., Gums, J. G., Turner, S. T., Boerwinkle, E., Scherer, S. E., Sadee, W., Cooper-DeHoff, R. M., Johnson, J. A. Tags: Gene Expression & Regulation, Genetic, Association Studies, Genetics, High Blood Pressure, Hypertension Original Articles Source Type: research

Inflammatory Biomarkers Predict Heart Failure Severity and Prognosis in Patients With Heart Failure With Preserved Ejection Fraction: A Holistic Proteomic Approach [Original Articles]
Conclusions— In HF with preserved ejection fraction, novel biomarkers of inflammation predict HF severity and prognosis that may complement or even outperform traditional markers, such as N-terminal probrain natriuretic peptide. These findings lend support to a hypothesis implicating global systemic inflammation in HF with preserved ejection fraction. Clinical Trial Registration— URL: http://www.clinicaltrials.gov; Unique identifier: NCT00774709. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - January 17, 2017 Category: Cardiology Authors: Hage, C., Michaelsson, E., Linde, C., Donal, E., Daubert, J.-C., Gan, L.-M., Lund, L. H. Tags: Heart Failure Original Articles Source Type: research

Effect of Metformin on Metabolites and Relation With Myocardial Infarct Size and Left Ventricular Ejection Fraction After Myocardial Infarction [Original Articles]
Conclusions— HDL triglyceride concentrations predict post-MI LVEF and ISZ. Metformin increases alanine levels and reduces the phospholipid content in very large HDL particles. Clinical Trial Registration— URL: https://clinicaltrials.gov/ct2/show/NCT01217307. Unique Identifier: NCT01217307. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - January 17, 2017 Category: Cardiology Authors: Eppinga, R. N., Kofink, D., Dullaart, R. P. F., Dalmeijer, G. W., Lipsic, E., van Veldhuisen, D. J., van der Horst, I. C. C., Asselbergs, F. W., van der Harst, P. Tags: Biomarkers, Lipids and Cholesterol, Secondary Prevention, Heart Failure, Myocardial Infarction Original Articles Source Type: research