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Clinical Outcomes and Sustainability of Using CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention [Original Articles]
Conclusions: Implementing CYP2C19 genotype–guided DAPT is feasible and sustainable in a real-world setting but challenging to maintain at a consistently high level of fidelity. The higher risk of major adverse cardiovascular or cerebrovascular associated with clopidogrel use in CYP2C19 LOF allele carriers suggests that use of genotype-guided DAPT in practice may improve clinical outcomes. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 3, 2018 Category: Cardiology Authors: Lee, C. R., Sriramoju, V. B., Cervantes, A., Howell, L. A., Varunok, N., Madan, S., Hamrick, K., Polasek, M. J., Lee, J. A., Clarke, M., Cicci, J. D., Weck, K. E., Stouffer, G. A. Tags: Genetics, Pharmacology, Acute Coronary Syndromes, Atherosclerosis Original Articles Source Type: research

Circulating Branched-Chain Amino Acids and Incident Cardiovascular Disease in a Prospective Cohort of US Women [Original Articles]
Conclusions: Circulating plasma BCAAs were positively associated with incident CVD in women. Impaired BCAA metabolism may capture the long-term risk of the common cause underlying T2D and CVD. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - March 23, 2018 Category: Cardiology Authors: Tobias, D. K., Lawler, P. R., Harada, P. H., Demler, O. V., Ridker, P. M., Manson, J. E., Cheng, S., Mora, S. Tags: Biomarkers, Cardiovascular Disease, Diabetes, Type 2, Epidemiology, Women Original Articles Source Type: research

In This Issue: March [In This Issue: March]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - March 20, 2018 Category: Cardiology Tags: In This Issue: March Source Type: research

Beyond Gene Panels: Whole Exome Sequencing for Diagnosis of Congenital Heart Disease [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - March 19, 2018 Category: Cardiology Authors: Paige, S. L., Saha, P., Priest, J. R. Tags: Developmental Biology, Genetics Editorial Source Type: research

Epigenetic Age Acceleration: A Biological Doomsday Clock for Cardiovascular Disease? [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - March 19, 2018 Category: Cardiology Authors: Mendelson, M. M. Tags: Biomarkers, Aging, Cardiovascular Disease, Epidemiology, Epigenetics Editorial Source Type: research

ET (Endothelin)-1 and Ischemic Heart Disease: A Mendelian Randomization Study [Research Letter]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - March 19, 2018 Category: Cardiology Authors: Schooling, C. M., Kodali, H., Li, S., Borrell, L. N. Tags: Endothelium/Vascular Type/Nitric Oxide, Diet and Nutrition, Genetics, Coronary Artery Disease Research Letter Source Type: research

A Screening Approach to Identify Clinically Actionable Variants Causing Congenital Heart Disease in Exome Data [Original Articles]
Conclusions: The pathogenesis of CHD could be explained using our high-confidence CHD gene list for variant filtering in a subset of cases. Furthermore, our unbiased screening procedure of family exomes implicates additional genes and variants in the pathogenesis of CHD, which suggest themselves for functional validation. This 2-tiered approach provides a means of (1) identifying clinically actionable variants and (2) identifying additional disease-causal genes, both of which are essential for improving the molecular diagnosis of CHD. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - March 19, 2018 Category: Cardiology Authors: Szot, J. O., Cuny, H., Blue, G. M., Humphreys, D. T., Ip, E., Harrison, K., Sholler, G. F., Giannoulatou, E., Leo, P., Duncan, E. L., Sparrow, D. B., Ho, J. W. K., Graham, R. M., Pachter, N., Chapman, G., Winlaw, D. S., Dunwoodie, S. L. Tags: Developmental Biology, Genetics, Congenital Heart Disease Original Articles Source Type: research

Prospective Study of Epigenetic Age Acceleration and Incidence of Cardiovascular Disease Outcomes in the ARIC Study (Atherosclerosis Risk in Communities) [Original Articles]
Conclusions: In this sample of blacks, increased epigenetic age acceleration in whole blood was a potential risk marker for incident fatal coronary heart disease, peripheral arterial disease, and heart failure independently of chronological age and traditional CVD risk factors. DNA methylation–based measures of biological aging may help to identify new pathophysiological mechanisms contributing to the development of CVD. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - March 19, 2018 Category: Cardiology Authors: Roetker, N. S., Pankow, J. S., Bressler, J., Morrison, A. C., Boerwinkle, E. Tags: Aging, Cardiovascular Disease, Epidemiology, Risk Factors, Epigenetics Original Articles Source Type: research

Noncoding Genetic Variation and Gene Expression: Deciphering the Molecular Drivers of Genome-Wide Association Study Signals in Atrial Fibrillation [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - March 15, 2018 Category: Cardiology Authors: Roberts, J. D. Tags: Atrial Fibrillation, Gene Expression & Regulation, Genetic, Association Studies Editorial Source Type: research

Genetic Control of Left Atrial Gene Expression Yields Insights into the Genetic Susceptibility for Atrial Fibrillation [Original Articles]
Conclusions: We provide a genome-wide catalog of the genetic control of gene expression in human left atrial appendage. These data can be used to confirm the relevance of genome-wide association loci and to direct future functional studies to identify the genes and genetic variants responsible for complex diseases such as AF. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - March 15, 2018 Category: Cardiology Authors: Hsu, J., Gore-Panter, S., Tchou, G., Castel, L., Lovano, B., Moravec, C. S., Pettersson, G. B., Roselli, E. E., Gillinov, A. M., McCurry, K. R., Smedira, N. G., Barnard, J., Van Wagoner, D. R., Chung, M. K., Smith, J. D. Tags: Arrhythmias, Gene Expression & Regulation, Functional Genomics Original Articles Source Type: research

Modeling Cardiomyopathy and Arrhythmias in Induced Pluripotent Stem Cell-Derived Cardiomyocytes [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - March 15, 2018 Category: Cardiology Authors: Chen, S. N., Taylor, M. R. G., Mestroni, L. Tags: Arrhythmias, Sudden Cardiac Death, Stem Cells, Genetics, Cardiomyopathy Editorial Source Type: research

Ion Channel Dysfunctions in Dilated Cardiomyopathy in Limb-Girdle Muscular Dystrophy [Original Articles]
Conclusions: This study demonstrates that patient-specific hiPSC cardiomyocytes can recapitulate some phenotypic properties of LGMD2I with DCM and provide a platform for studies on the cardiac events in LGMD. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - March 15, 2018 Category: Cardiology Authors: El-Battrawy, I., Zhao, Z., Lan, H., Li, X., Yucel, G., Lang, S., Sattler, K., Schunemann, J.-D., Zimmermann, W.-H., Cyganek, L., Utikal, J., Wieland, T., Bieback, K., Bauer, R., Ratte, A., Pribe-Wolferts, R., Rapti, K., Nowak, D., Wittig, J., Thomas, D., Tags: Arrhythmias, Sudden Cardiac Death, Stem Cells, Translational Studies, Cardiomyopathy Original Articles Source Type: research

Divergent Effects of PKC (Protein Kinase C) {alpha} in the Human and Animal Heart?: Therapeutic Implications for PKC Inhibitors in Cardiac Patients [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - March 14, 2018 Category: Cardiology Authors: Weeks, K. L., McMullen, J. R. Tags: Myocardial Biology Editorial Source Type: research

Genetic Reduction in Left Ventricular Protein Kinase C-{alpha} and Adverse Ventricular Remodeling in Human Subjects [Original Articles]
Conclusions: These findings support PKC-α as a regulator of the human heart but suggest that PKC-α inhibition may adversely affect the left ventricle depending on timing and duration. Pharmacological studies in human subjects are required to discern potential benefits and harms of PKC-α inhibitors as an approach to treat heart disease. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - March 14, 2018 Category: Cardiology Authors: Hu, R., Morley, M. P., Brandimarto, J., Tucker, N. R., Parsons, V. A., Zhao, S. D., Meder, B., Katus, H. A., Ruhle, F., Stoll, M., Villard, E., Cambien, F., Lin, H., Smith, N. L., Felix, J. F., Vasan, R. S., van der Harst, P., Newton-Cheh, C., Li, J., Kim Tags: Translational Studies, Gene Expression & Regulation, Genetics, Heart Failure Original Articles Source Type: research

Hyperacute Monocyte Gene Response Patterns Are Associated With Lower Extremity Vein Bypass Graft Failure [Original Articles]
Conclusions: A novel combination of dynamic gene clustering, linear models, and Bayesian network analysis has identified a core set of regulatory genes whose manipulations could migrate vein grafts toward a more favorable remodeling phenotype. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - March 12, 2018 Category: Cardiology Authors: Rehfuss, J. P., DeSart, K. M., Rozowsky, J. M., OMalley, K. A., Moldawer, L. L., Baker, H. V., Wang, Y., Wu, R., Nelson, P. R., Berceli, S. A. Tags: Computational Biology, Inflammation, Functional Genomics, Revascularization, Peripheral Vascular Disease Original Articles Source Type: research