Genetic Reduction in Left Ventricular Protein Kinase C-{alpha} and Adverse Ventricular Remodeling in Human Subjects [Original Articles]

Conclusions:
These findings support PKC-α as a regulator of the human heart but suggest that PKC-α inhibition may adversely affect the left ventricle depending on timing and duration. Pharmacological studies in human subjects are required to discern potential benefits and harms of PKC-α inhibitors as an approach to treat heart disease.

Source: Circulation: Cardiovascular Genetics - March 14, 2018 Category: Cardiology Authors: Hu, R., Morley, M. P., Brandimarto, J., Tucker, N. R., Parsons, V. A., Zhao, S. D., Meder, B., Katus, H. A., Ruhle, F., Stoll, M., Villard, E., Cambien, F., Lin, H., Smith, N. L., Felix, J. F., Vasan, R. S., van der Harst, P., Newton-Cheh, C., Li, J., Kim Tags: Translational Studies, Gene Expression & Regulation, Genetics, Heart Failure Original Articles Source Type: research