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High Heart: A Role for Calcineurin Signaling in Hypoxia-Influenced Cardiac Growth [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - October 6, 2017 Category: Cardiology Authors: Lovato, T. L., Cripps, R. M. Tags: Animal Models of Human Disease, Cellular Reprogramming, Myocardial Biology, Physiology, Genetically Altered and Transgenic Models Editorial Source Type: research

Pathogenicity of Hypertrophic Cardiomyopathy Variants: A Path Forward Together [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - October 6, 2017 Category: Cardiology Authors: Ingles, J., Burns, C., Funke, B. Tags: Genetics Editorial Source Type: research

Genomic Triangulation in Sudden Unexplained Death in the Young: The Way to Go? [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - October 6, 2017 Category: Cardiology Authors: Bartels, E. D., Tfelt-Hansen, J., Winkel, B. G. Tags: Sudden Cardiac Death, Genetics Editorial Source Type: research

Biases in Genetic Association of Coronary Heart Disease Events May Be Less Likely Than Suspected: Here Is When to Check for Them [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - October 6, 2017 Category: Cardiology Authors: Dungan, J. R. Tags: Cardiovascular Disease, Epidemiology, Genetic, Association Studies, Myocardial Infarction, Coronary Artery Disease Editorial Source Type: research

Genomic Triangulation and Coverage Analysis in Whole-Exome Sequencing-Based Molecular Autopsies [Original Articles]
Conclusions— An SDY-parent, trio-based WEMA may be an effective way of elucidating a monogenic cause of death and bringing clarity to otherwise ambiguous variants. If other studies confirm this relatively high rate of SDY cases stemming from de novo mutations, then the WEMA should become even more cost-effective given that the decedent’s first-degree relatives should only need minimal cardiological evaluation. In addition, autopsy-sourced DNA demonstrated strikingly lower whole-exome sequencing coverage than DNA from fresh blood draw. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - October 6, 2017 Category: Cardiology Authors: Shanks, G. W., Tester, D. J., Nishtala, S., Evans, J. M., Ackerman, M. J. Tags: Arrhythmias, Sudden Cardiac Death, Ion Channels/Membrane Transport, Genetics, Hypertrophy Original Articles Source Type: research

Validation of Polygenic Scores for QT Interval in Clinical Populations [Original Articles]
Conclusions— For individuals of European descent, PGS provided a significant increase in variation in QT interval explained compared with a model with only nongenetic factors at nearly every significance level. There was no apparent benefit gained by relaxing the significance threshold from conventional genome-wide significance (P<5x10–8). (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - October 6, 2017 Category: Cardiology Authors: Rosenberg, M. A., Lubitz, S. A., Lin, H., Kosova, G., Castro, V. M., Huang, P., Ellinor, P. T., Perlis, R. H., Newton-Cheh, C. Tags: Epidemiology, Genetics Original Articles Source Type: research

Reduced Cardiac Calcineurin Expression Mimics Long-Term Hypoxia-Induced Heart Defects in Drosophila [Original Articles]
Conclusions— Our results suggest a key role for calcineurin in cardiac remodeling during long-term hypoxia with implications for diseases of chronic hypoxia, and it likely contributes to mechanisms underlying these disease states. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - October 6, 2017 Category: Cardiology Authors: Zarndt, R., Walls, S. M., Ocorr, K., Bodmer, R. Tags: Arrhythmias, Genetics, Heart Failure Original Articles Source Type: research

Care in Specialized Centers and Data Sharing Increase Agreement in Hypertrophic Cardiomyopathy Genetic Test Interpretation [Original Articles]
Conclusions— Discordance in variant classification among hypertrophic cardiomyopathy centers is largely attributable to privately held data. Some discrepancies are caused by differences in expert assessment of conflicting data. Discordance was markedly lower among centers specialized in hypertrophic cardiomyopathy than among clinical laboratories, suggesting that optimal genetic test interpretation occurs in the context of clinical care delivered by specialized centers with both clinical and genetics expertise. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - October 6, 2017 Category: Cardiology Authors: Furqan, A., Arscott, P., Girolami, F., Cirino, A. L., Michels, M., Day, S. M., Olivotto, I., Ho, C. Y., Ashley, E., Green, E. M., Caleshu, C., on behalf of the SHaRe Consortium Tags: Clinical Studies, Genetics, Cardiomyopathy, Hypertrophy, Diagnostic Testing Original Articles Source Type: research

Impact of Selection Bias on Estimation of Subsequent Event Risk [Original Articles]
Conclusions— In most empirical settings, selection bias is expected to have a limited impact on genetic effect estimates of subsequent event risk. Nevertheless, because of undercoverage increasing with sample size, most confidence intervals will be over precise (not wide enough). When there is no effect modification by history of coronary heart disease, the false-positive rates of association tests will be close to nominal. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - October 6, 2017 Category: Cardiology Authors: Hu, Y.-J., Schmidt, A. F., Dudbridge, F., Holmes, M. V., Brophy, J. M., Tragante, V., Li, Z., Liao, P., Quyyumi, A. A., McCubrey, R. O., Horne, B. D., Hingorani, A. D., Asselbergs, F. W., Patel, R. S., Long, Q., on behalf of the GENIUS-CHD Consortium Tags: Cardiovascular Disease, Secondary Prevention, Genetics, Quality and Outcomes Original Articles Source Type: research

What Do We Really Think About Human Germline Genome Editing, and What Does It Mean for Medicine? [Perspective]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - October 3, 2017 Category: Cardiology Authors: Musunuru, K., Lagor, W. R., Miano, J. M. Tags: Gene Therapy, Genetics Perspective Source Type: research

Letter by Brewster Regarding Article, "CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia" [Correspondence]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - September 28, 2017 Category: Cardiology Authors: Brewster, L. M. Tags: Biomarkers, Gene Expression & Regulation Correspondence Source Type: research

Connecting the Dots in Atrial Fibrillation [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - September 28, 2017 Category: Cardiology Authors: Nurnberg, S. T. Tags: Atrial Fibrillation, Mechanisms, Genetic, Association Studies Editorial Source Type: research

Diminished PRRX1 Expression Is Associated With Increased Risk of Atrial Fibrillation and Shortening of the Cardiac Action Potential [Original Articles]
Conclusions— We have identified a functional genetic variant that alters PRRX1 expression, ultimately resulting in electrophysiological alterations in atrial myocytes that may promote AF. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - September 28, 2017 Category: Cardiology Authors: Tucker, N. R., Dolmatova, E. V., Lin, H., Cooper, R. R., Ye, J., Hucker, W. J., Jameson, H. S., Parsons, V. A., Weng, L.-C., Mills, R. W., Sinner, M. F., Imakaev, M., Leyton-Mange, J., Vlahakes, G., Benjamin, E. J., Lunetta, K. L., Lubitz, S. A., Mirny, L Tags: Arrhythmias, Atrial Fibrillation, Translational Studies, Genetic, Association Studies, Functional Genomics Original Articles Source Type: research

Insights From the Positive Association of Height With Incident Venous Thromboembolism [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - September 5, 2017 Category: Cardiology Authors: Schooling, C. M. Tags: Etiology, Cardiovascular Disease, Thrombosis Editorial Source Type: research

Body Height and Incident Risk of Venous Thromboembolism: A Cosibling Design [Original Articles]
Conclusions— Height is an independent predictor of VTE. The use of sibling pairs reduces the likelihood that familial confounding explains the results. The findings are important for the understanding of the pathogenesis of VTE. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - September 5, 2017 Category: Cardiology Authors: Zoller, B., Ji, J., Sundquist, J., Sundquist, K. Tags: Epidemiology, Risk Factors, Genetics, Embolism, Thrombosis Original Articles Source Type: research