Validation of Polygenic Scores for QT Interval in Clinical Populations [Original Articles]

Conclusions— For individuals of European descent, PGS provided a significant increase in variation in QT interval explained compared with a model with only nongenetic factors at nearly every significance level. There was no apparent benefit gained by relaxing the significance threshold from conventional genome-wide significance (P<5x10–8).

http://circgenetics.ahajournals.org/cgi/content/short/10/5/e001724?rss=1

Source: Circulation: Cardiovascular Genetics - October 6, 2017 Category: Cardiology Authors: Rosenberg, M. A., Lubitz, S. A., Lin, H., Kosova, G., Castro, V. M., Huang, P., Ellinor, P. T., Perlis, R. H., Newton-Cheh, C. Tags: Epidemiology, Genetics Original Articles Source Type: research