Impact of Selection Bias on Estimation of Subsequent Event Risk [Original Articles]

Conclusions— In most empirical settings, selection bias is expected to have a limited impact on genetic effect estimates of subsequent event risk. Nevertheless, because of undercoverage increasing with sample size, most confidence intervals will be over precise (not wide enough). When there is no effect modification by history of coronary heart disease, the false-positive rates of association tests will be close to nominal.
Source: Circulation: Cardiovascular Genetics - Category: Cardiology Authors: Tags: Cardiovascular Disease, Secondary Prevention, Genetics, Quality and Outcomes Original Articles Source Type: research