Diminished PRRX1 Expression Is Associated With Increased Risk of Atrial Fibrillation and Shortening of the Cardiac Action Potential [Original Articles]

Conclusions—
We have identified a functional genetic variant that alters PRRX1 expression, ultimately resulting in electrophysiological alterations in atrial myocytes that may promote AF.

Source: Circulation: Cardiovascular Genetics - September 28, 2017 Category: Cardiology Authors: Tucker, N. R., Dolmatova, E. V., Lin, H., Cooper, R. R., Ye, J., Hucker, W. J., Jameson, H. S., Parsons, V. A., Weng, L.-C., Mills, R. W., Sinner, M. F., Imakaev, M., Leyton-Mange, J., Vlahakes, G., Benjamin, E. J., Lunetta, K. L., Lubitz, S. A., Mirny, L Tags: Arrhythmias, Atrial Fibrillation, Translational Studies, Genetic, Association Studies, Functional Genomics Original Articles Source Type: research