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Family Matters: Outcomes of Hypertrophic Cardiomyopathy Family Screening [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 16, 2018 Category: Cardiology Authors: Ingles, J., Semsarian, C. Tags: Genetics, Cardiomyopathy, Hypertrophy Editorial Source Type: research

Outcomes of Contemporary Family Screening in Hypertrophic Cardiomyopathy [Original Articles]
Conclusions: HCM was identified in 30% of relatives at first screening, and 16% developed HCM during 7 years of repeated evaluation. GT led to a discharge from clinical follow-up in 46% of the study population. Survival in the relatives was good. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 16, 2018 Category: Cardiology Authors: van Velzen, H. G., Schinkel, A. F. L., Baart, S. J., Oldenburg, R. A., Frohn-Mulder, I. M. E., van Slegtenhorst, M. A., Michels, M. Tags: Clinical Studies, Genetics, Cardiomyopathy, Hypertrophy, Mortality/Survival Original Articles Source Type: research

Functional Assays to Screen and Dissect Genomic Hits: Doubling Down on the National Investment in Genomic Research [White Paper]
The National Institutes of Health have made substantial investments in genomic studies and technologies to identify DNA sequence variants associated with human disease phenotypes. The National Heart, Lung, and Blood Institute has been at the forefront of these commitments to ascertain genetic variation associated with heart, lung, blood, and sleep diseases and related clinical traits. Genome-wide association studies, exome- and genome-sequencing studies, and exome-genotyping studies of the National Heart, Lung, and Blood Institute–funded epidemiological and clinical case–control studies are identifying large nu...
Source: Circulation: Cardiovascular Genetics - April 13, 2018 Category: Cardiology Authors: Musunuru, K., Bernstein, D., Cole, F. S., Khokha, M. K., Lee, F. S., Lin, S., McDonald, T. V., Moskowitz, I. P., Quertermous, T., Sankaran, V. G., Schwartz, D. A., Silverman, E. K., Zhou, X., Hasan, A. A. K., Luo, X.-z. J. Tags: Gene Expression & Regulation, Genetic, Association Studies, Genetically Altered and Transgenic Models, Genetics, Functional Genomics White Paper Source Type: research

Branched-Chain Amino Acids: The Metabolic Link Between Type 2 Diabetes Mellitus and Cardiovascular Disease? [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 12, 2018 Category: Cardiology Authors: Tuteja, S. Tags: Cardiovascular Disease, Diabetes, Type 2, Epidemiology, Risk Factors, Women Editorial Source Type: research

Genetics of Spontaneous Coronary Artery Dissection Gains New Momentum [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 12, 2018 Category: Cardiology Authors: Grond-Ginsbach, C., Engelter, S. T. Tags: Genetics, Acute Coronary Syndromes Editorial Source Type: research

Response by Ma et al to Letter Regarding Article, "Novel Mutation in FLNC (Filamin C) Causes Familial Restrictive Cardiomyopathy" [Response to Letter to the Editor]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 12, 2018 Category: Cardiology Authors: Tucker, N. R., Ellinor, P. T. Tags: Contractile Function, Genetics, Cardiomyopathy Response to Letter to the Editor Source Type: research

Is Plasma Renin Activity Genetically Determined and How Much Does It Matter for Treating Hypertension? [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 12, 2018 Category: Cardiology Authors: Alhenc-Gelas, F., Menard, J. Tags: ACE/Angiotensin Receptors/Renin Angiotensin System, Clinical Studies, Genetic, Association Studies, Hypertension, Pharmacology Editorial Source Type: research

Lung Function and Coronary Artery Disease Risk [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 12, 2018 Category: Cardiology Authors: Nowak, C. Tags: Cardiovascular Disease, Epidemiology, Risk Factors, Genetics, Coronary Artery Disease Editorial Source Type: research

Letter by Ma et al Regarding Article, "Novel Mutation in FLNC (Filamin C) Causes Familial Restrictive Cardiomyopathy" [Letter to the Editor]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 12, 2018 Category: Cardiology Authors: Ma, Y., Huang, J., Zhou, Z. Tags: Atrial Fibrillation, Genetics, Cardiomyopathy Letter to the Editor Source Type: research

Association of Genetic Instrumental Variables for Lung Function on Coronary Artery Disease Risk: A 2-Sample Mendelian Randomization Study [Original Articles]
Conclusions: Our study suggested an inverse relation between FEV1 and CAD, but for FVC, evidence is less clear. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 12, 2018 Category: Cardiology Authors: Au Yeung, S. L., Borges, M.-C., Lawlor, D. A. Tags: Cardiovascular Disease, Epidemiology, Risk Factors, Genetics, Coronary Artery Disease Original Articles Source Type: research

Prospective Cardiovascular Genetics Evaluation in Spontaneous Coronary Artery Dissection [Original Articles]
Conclusions: In this series, 8.2% of the SCAD patients evaluated had a molecularly identifiable disorder associated with vascular disease. The most common diagnosis was vascular Ehlers–Danlos syndrome. Patients with positive gene testing were significantly younger at the time of their first SCAD event. A low threshold for genetic testing should be considered in patients with SCAD. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 12, 2018 Category: Cardiology Authors: Kaadan, M. I., MacDonald, C., Ponzini, F., Duran, J., Newell, K., Pitler, L., Lin, A., Weinberg, I., Wood, M. J., Lindsay, M. E. Tags: Genetics, Aneurysm, Vascular Disease Original Articles Source Type: research

Genetic Variants Influencing Plasma Renin Activity in Hypertensive Patients From the PEAR Study (Pharmacogenomic Evaluation of Antihypertensive Responses) [Original Articles]
Conclusions: We identified multiple regions associated with baseline PRA that were prioritized through BP response signals to 2 mechanistically different antihypertensive drugs. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT00246519. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 12, 2018 Category: Cardiology Authors: McDonough, C. W., Magvanjav, O., Sa, A. C. C., El Rouby, N. M., Dave, C., Deitchman, A. N., Kawaguchi-Suzuki, M., Mei, W., Shen, Y., Singh, R. S. P., Solayman, M., Bailey, K. R., Boerwinkle, E., Chapman, A. B., Gums, J. G., Webb, A., Scherer, S. E., Sadee Tags: Genetic, Association Studies, High Blood Pressure, Hypertension, Pharmacology Original Articles Source Type: research

Whos Who of Pulmonary Hypertension: Redefining Classification to Advance Precision Care [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 9, 2018 Category: Cardiology Authors: Cirulis, M. M., Ryan, J. J. Tags: Pulmonary Biology, Mechanisms, Pathophysiology, Translational Studies, Vascular Biology Editorial Source Type: research

Exome Sequencing in Children With Pulmonary Arterial Hypertension Demonstrates Differences Compared With Adults [Original Articles]
Conclusions: Mutations in known PAH risk genes accounted for 70% to 80% of FPAH in both age groups, 21% of pediatric-onset IPAH, and 11% of adult-onset IPAH. Rare, predicted deleterious variants in TBX4 are enriched in pediatric patients and de novo variants in novel genes may explain 19% of pediatric-onset IPAH cases. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 9, 2018 Category: Cardiology Authors: Zhu, N., Gonzaga-Jauregui, C., Welch, C. L., Ma, L., Qi, H., King, A. K., Krishnan, U., Rosenzweig, E. B., Ivy, D. D., Austin, E. D., Hamid, R., Nichols, W. C., Pauciulo, M. W., Lutz, K. A., Sawle, A., Reid, J. G., Overton, J. D., Baras, A., Dewey, F., Sh Tags: Pediatrics, Genetic, Association Studies, Pulmonary Hypertension Original Articles Source Type: research

Implementation of Genotype-Guided Antiplatelet Therapy: Feasible but Not Without Obstacles [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 3, 2018 Category: Cardiology Authors: Lewis, J. P. Tags: Translational Studies, Genetics, Pharmacology, Acute Coronary Syndromes, Thrombosis Editorial Source Type: research