Genetic Variants Influencing Plasma Renin Activity in Hypertensive Patients From the PEAR Study (Pharmacogenomic Evaluation of Antihypertensive Responses) [Original Articles]

Conclusions: We identified multiple regions associated with baseline PRA that were prioritized through BP response signals to 2 mechanistically different antihypertensive drugs. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT00246519.

http://circgenetics.ahajournals.org/cgi/content/short/11/4/e001854?rss=1

Source: Circulation: Cardiovascular Genetics - April 12, 2018 Category: Cardiology Authors: McDonough, C. W., Magvanjav, O., Sa, A. C. C., El Rouby, N. M., Dave, C., Deitchman, A. N., Kawaguchi-Suzuki, M., Mei, W., Shen, Y., Singh, R. S. P., Solayman, M., Bailey, K. R., Boerwinkle, E., Chapman, A. B., Gums, J. G., Webb, A., Scherer, S. E., Sadee Tags: Genetic, Association Studies, High Blood Pressure, Hypertension, Pharmacology Original Articles Source Type: research