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Improving Genomic Literacy Among Cardiovascular Practitioners via a Flipped-Classroom Workshop at a National Meeting [Special Report]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 20, 2016 Category: Cardiology Authors: Musunuru, K., Haspel, R. L., on behalf of the Innovative Approaches to Education Working Group of the Inter-Society Coordinating Committee for Practitioner Education in Genomics Tags: Genetics Special Report Source Type: research

Cardiovascular Risk Factors and Ischemic Heart Disease: Is the Confluence of Risk Factors Greater Than the Parts? A Genetic Approach [Original Articles]
Conclusions— The confluence of low-density lipoprotein cholesterol and triglycerides genetic risk load has an additive effect on IHD risk. The interaction between low-density lipoprotein cholesterol and IHD genetic load is more than multiplicative, supporting the hazardous impact on atherosclerosis progression of the combination of inflammation and increased lipid levels. The capacity of risk factor confluence to improve IHD risk prediction is questionable. Further studies in larger samples are warranted to confirm and expand our results. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 20, 2016 Category: Cardiology Authors: Elosua, R., Lluis-Ganella, C., Subirana, I., Havulinna, A., Lall, K., Lucas, G., Sayols-Baixeras, S., Pietila, A., Alver, M., Cabrera de Leon, A., Senti, M., Siscovick, D., Mellander, O., Fischer, K., Salomaa, V., Marrugat, J. Tags: Epidemiology, Primary Prevention, Risk Factors, Genetic, Association Studies Original Articles Source Type: research

International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents [Original Articles]
Conclusions— Our results suggest that genetic determinants of BP act from childhood, develop over the lifecourse, and show some evidence of age-specific effects. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 20, 2016 Category: Cardiology Authors: Parmar, P. G., Taal, H. R., Timpson, N. J., Thiering, E., Lehtimaki, T., Marinelli, M., Lind, P. A., Howe, L. D., Verwoert, G., Aalto, V., Uitterlinden, A. G., Briollais, L., Evans, D. M., Wright, M. J., Newnham, J. P., Whitfield, J. B., Lyytikainen, L.-P Tags: Epidemiology, Genetic, Association Studies, High Blood Pressure, Meta Analysis Original Articles Source Type: research

Whole-Exome Molecular Autopsy After Exertion-Related Sudden Unexplained Death in the Young [Original Articles]
Conclusions— Molecular screening in this clinical scenario is appropriate with a pathogenic mutation detection rate of 44% using direct DNA sequencing followed by whole-exome sequencing. Only 5 of the 100 interrogated sudden death genes hosted actionable pathogenic mutations for more than one third of these exertion-related, autopsy-negative SUDY cases. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 20, 2016 Category: Cardiology Authors: Anderson, J. H., Tester, D. J., Will, M. L., Ackerman, M. J. Tags: Sudden Cardiac Death, Ion Channels/Membrane Transport, Pediatrics, Genetics Original Articles Source Type: research

Common and Rare Genetic Variation in CCR2, CCR5, or CX3CR1 and Risk of Atherosclerotic Coronary Heart Disease and Glucometabolic Traits [Original Articles]
Conclusions— No chemokine receptor variant was associated with CAD, MI, or glucometabolic traits in large European ancestry cohorts. In a South Asian cohort, we identified single nucleotide polymorphism associations with MI and type II diabetes mellitus but these did not meet significance in cohorts of European ancestry. These findings suggest the need for larger studies in South Asians but exclude clinically meaningful associations with CAD and glucometabolic traits in Europeans. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 20, 2016 Category: Cardiology Authors: Golbus, J. R., Stitziel, N. O., Zhao, W., Xue, C., Farrall, M., McPherson, R., Erdmann, J., Deloukas, P., Watkins, H., Schunkert, H., Samani, N. J., Saleheen, D., Kathiresan, S., Reilly, M. P., on behalf of CARDIoGRAMplusC4D, Myocardial Infarction Genetic Tags: Cardiovascular Disease, Genetic, Association Studies, Functional Genomics Original Articles Source Type: research