Common and Rare Genetic Variation in CCR2, CCR5, or CX3CR1 and Risk of Atherosclerotic Coronary Heart Disease and Glucometabolic Traits [Original Articles]

Conclusions— No chemokine receptor variant was associated with CAD, MI, or glucometabolic traits in large European ancestry cohorts. In a South Asian cohort, we identified single nucleotide polymorphism associations with MI and type II diabetes mellitus but these did not meet significance in cohorts of European ancestry. These findings suggest the need for larger studies in South Asians but exclude clinically meaningful associations with CAD and glucometabolic traits in Europeans.

http://circgenetics.ahajournals.org/cgi/content/short/9/3/250?rss=1

Source: Circulation: Cardiovascular Genetics - June 20, 2016 Category: Cardiology Authors: Golbus, J. R., Stitziel, N. O., Zhao, W., Xue, C., Farrall, M., McPherson, R., Erdmann, J., Deloukas, P., Watkins, H., Schunkert, H., Samani, N. J., Saleheen, D., Kathiresan, S., Reilly, M. P., on behalf of CARDIoGRAMplusC4D, Myocardial Infarction Genetic Tags: Cardiovascular Disease, Genetic, Association Studies, Functional Genomics Original Articles Source Type: research