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Prediction of Adult Dyslipidemia Using Genetic and Childhood Clinical Risk Factors: The Cardiovascular Risk in Young Finns Study [Original Articles]
Conclusions— The inclusion of weighted genetic risk scores to lipid-screening programs in childhood could modestly improve the identification of those at highest risk of dyslipidemia in adulthood. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 15, 2017 Category: Cardiology Authors: Nuotio, J., Pitkanen, N., Magnussen, C. G., Buscot, M.-J., Venalainen, M. S., Elo, L. L., Jokinen, E., Laitinen, T., Taittonen, L., Hutri-Kahonen, N., Lyytikainen, L.-P., Lehtimaki, T., Viikari, J. S., Juonala, M., Raitakari, O. T. Tags: Lipids and Cholesterol, Risk Factors, Genetics Original Articles Source Type: research

Prediction of Adulthood Obesity Using Genetic and Childhood Clinical Risk Factors in the Cardiovascular Risk in Young Finns Study [Original Articles]
Conclusions— WGRS19 improves prediction of adulthood obesity. Predictive accuracy is highest among young children (3–6 years), whereas among older children (9–18 years) the risk can be identified using childhood clinical factors. The model is helpful in screening children with high risk of developing obesity. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 15, 2017 Category: Cardiology Authors: Seyednasrollah, F., Makela, J., Pitkanen, N., Juonala, M., Hutri-Kahonen, N., Lehtimaki, T., Viikari, J., Kelly, T., Li, C., Bazzano, L., Elo, L. L., Raitakari, O. T. Tags: Computational Biology, Clinical Studies, Epidemiology, Obesity, Genetics Original Articles Source Type: research

Ancestry, Telomere Length, and Atherosclerosis Risk [Advances in Genetics]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 14, 2017 Category: Cardiology Authors: Benetos, A., Aviv, A. Tags: Race and Ethnicity, Genetics, Atherosclerosis Advances in Genetics Source Type: research

Burden of Recurrent and Ancestral Mutations in Families With Hypertrophic Cardiomyopathy [Original Articles]
Conclusions— The majority of families with a causal variant identified have a nonunique variant. Discovery of the genetic origins of human disease forms a fundamental basis for improved understanding of disease pathogenesis and phenotype development. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 14, 2017 Category: Cardiology Authors: Ross, S. B., Bagnall, R. D., Ingles, J., Van Tintelen, J. P., Semsarian, C. Tags: Genetics, Cardiomyopathy, Hypertrophy Original Articles Source Type: research

Dark Side of the Deep Heart [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 13, 2017 Category: Cardiology Authors: Cencioni, C., Spallotta, F., Gaetano, C. Tags: Animal Models of Human Disease, Ischemia, Gene Expression & Regulation, Myocardial Infarction Editorial Source Type: research

Metabolic Anthropology: Selection Pressure Shapes Fatty Acid Metabolism in Greenlandic Inuit Populations [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 13, 2017 Category: Cardiology Authors: McGarrah, R. W. Tags: Genetic, Association Studies, Functional Genomics Editorial Source Type: research

The Missing LINC for Genetic Cardiovascular Disease? [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 13, 2017 Category: Cardiology Authors: Puckelwartz, M. J. Tags: Animal Models of Human Disease, Genetically Altered and Transgenic Models, Genetics, Cardiomyopathy Editorial Source Type: research

Repeats and Survival in Myotonic Dystrophy Type 1 [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 13, 2017 Category: Cardiology Authors: Wheeler, M. T. Tags: Arrhythmias, Sudden Cardiac Death, Genetics, Cardiomyopathy, Electrocardiology (ECG) Editorial Source Type: research

Genome-Wide Dynamics of Nascent Noncoding RNA Transcription in Porcine Heart After Myocardial Infarction [Original Articles]
Conclusions— Global run-on sequencing allowed us to follow the gradient of gene expression occurring in the ischemic heart and identify novel noncoding RNAs regulated by oxygen deprivation. These findings highlight potential new targets for diagnosis and treatment of myocardial ischemia. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 13, 2017 Category: Cardiology Authors: Kaikkonen, M. U., Halonen, P., Liu, O. H.-F., Turunen, T. A., Pajula, J., Moreau, P., Selvarajan, I., Tuomainen, T., Aavik, E., Tavi, P., Yla-Herttuala, S. Tags: Animal Models of Human Disease, Ischemia, Gene Expression & Regulation, Myocardial Infarction Original Articles Source Type: research

CPT1A Missense Mutation Associated With Fatty Acid Metabolism and Reduced Height in Greenlanders [Original Articles]
Conclusion— Our study shows that a common CPT1A missense mutation is strongly associated with a range of metabolic phenotypes and reduced height in Greenlanders. These findings are important from a public health perspective and highlight the usefulness of complex trait genetic studies in isolated populations. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 13, 2017 Category: Cardiology Authors: Skotte, L., Koch, A., Yakimov, V., Zhou, S., Soborg, B., Andersson, M., Michelsen, S. W., Navne, J. E., Mistry, J. M., Dion, P. A., Pedersen, M. L., Borresen, M. L., Rouleau, G. A., Geller, F., Melbye, M., Feenstra, B. Tags: Metabolism, Genetic, Association Studies Original Articles Source Type: research

Association Between Mutation Size and Cardiac Involvement in Myotonic Dystrophy Type 1: An Analysis of the DM1-Heart Registry [Original Articles]
Conclusions— The size of the CTG expansion in the blood of myotonic dystrophy type 1 patients is associated with total and sudden deaths, conduction defects, left ventricular dysfunction, and supraventricular arrhythmias. Clinical Trial Registration— URL: https://www.clinicaltrials.gov. Unique Identifier: NCT01136330 (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 13, 2017 Category: Cardiology Authors: Chong-Nguyen, C., Wahbi, K., Algalarrondo, V., Becane, H. M., Radvanyi-Hoffman, H., Arnaud, P., Furling, D., Lazarus, A., Bassez, G., Behin, A., Fayssoil, A., Laforet, P., Stojkovic, T., Eymard, B., Duboc, D. Tags: Arrhythmias, Sudden Cardiac Death, Genetics, Cardiomyopathy, Mortality/Survival Original Articles Source Type: research

Whole Exome Sequencing Identifies Truncating Variants in Nuclear Envelope Genes in Patients With Cardiovascular Disease [Original Articles]
Conclusions— These data expand the repertoire of pathogenic variants associated with cardiovascular disease and validate the diagnostic and research use of whole exome sequencing. We identify NUP37, NUP43, and NUP188 as novel candidate genes for cardiovascular disease, and suggest that dysfunction of the nuclear envelope may be an under-recognized component of inherited cardiac disease in some cases. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 13, 2017 Category: Cardiology Authors: Haskell, G. T., Jensen, B. C., Samsa, L. A., Marchuk, D., Huang, W., Skrzynia, C., Tilley, C., Seifert, B. A., Rivera-Munoz, E. A., Koller, B., Wilhelmsen, K. C., Liu, J., Alhosaini, H., Weck, K. E., Evans, J. P., Berg, J. S. Tags: Translational Studies, Genetics, Functional Genomics, Congenital Heart Disease Original Articles Source Type: research

Marfan Syndrome: Always Evolving [Editorials]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 9, 2017 Category: Cardiology Authors: Jondeau, G., Boileau, C., Milleron, O. Tags: Genetics, Aneurysm, Aortic Dissection, Vascular Disease Editorials Source Type: research

Genetic Causes in Cardiac Arrest Survivors: Fake News or the Real Deal? [Editorials]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 9, 2017 Category: Cardiology Authors: Semsarian, C., Wilde, A. A. M. Tags: Arrhythmias, Sudden Cardiac Death, Genetics Editorials Source Type: research

Genetic Testing in the Evaluation of Unexplained Cardiac Arrest: From the CASPER (Cardiac Arrest Survivors With Preserved Ejection Fraction Registry) [Original Articles]
Conclusions— Genetic testing identifies a pathogenic variant in a significant proportion of unexplained cardiac arrest survivors. Prior syncope and family history of sudden death are predictors of a positive genetic test. Both arrhythmia and cardiomyopathy genes are implicated. Broad, multiphenotype testing revealed the highest frequency of pathogenic variants in phenotype-negative patients. Clinical Trial Registration— https://www.clinicaltrials.gov. Unique Identifier: NCT00292032 (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 9, 2017 Category: Cardiology Authors: Mellor, G., Laksman, Z. W. M., Tadros, R., Roberts, J. D., Gerull, B., Simpson, C. S., Klein, G. J., Champagne, J., Talajic, M., Gardner, M., Steinberg, C., Arbour, L., Birnie, D. H., Angaran, P., Leather, R., Sanatani, S., Chauhan, V. S., Seifer, C., Hea Tags: Sudden Cardiac Death, Ventricular Fibrillation, Clinical Studies, Genetics Original Articles Source Type: research