Association Between Mutation Size and Cardiac Involvement in Myotonic Dystrophy Type 1: An Analysis of the DM1-Heart Registry [Original Articles]

Conclusions— The size of the CTG expansion in the blood of myotonic dystrophy type 1 patients is associated with total and sudden deaths, conduction defects, left ventricular dysfunction, and supraventricular arrhythmias. Clinical Trial Registration— URL: https://www.clinicaltrials.gov. Unique Identifier: NCT01136330

http://circgenetics.ahajournals.org/cgi/content/short/10/3/e001526?rss=1

Source: Circulation: Cardiovascular Genetics - June 13, 2017 Category: Cardiology Authors: Chong-Nguyen, C., Wahbi, K., Algalarrondo, V., Becane, H. M., Radvanyi-Hoffman, H., Arnaud, P., Furling, D., Lazarus, A., Bassez, G., Behin, A., Fayssoil, A., Laforet, P., Stojkovic, T., Eymard, B., Duboc, D. Tags: Arrhythmias, Sudden Cardiac Death, Genetics, Cardiomyopathy, Mortality/Survival Original Articles Source Type: research