Genetic Testing in the Evaluation of Unexplained Cardiac Arrest: From the CASPER (Cardiac Arrest Survivors With Preserved Ejection Fraction Registry) [Original Articles]

Conclusions— Genetic testing identifies a pathogenic variant in a significant proportion of unexplained cardiac arrest survivors. Prior syncope and family history of sudden death are predictors of a positive genetic test. Both arrhythmia and cardiomyopathy genes are implicated. Broad, multiphenotype testing revealed the highest frequency of pathogenic variants in phenotype-negative patients. Clinical Trial Registration— https://www.clinicaltrials.gov. Unique Identifier: NCT00292032

http://circgenetics.ahajournals.org/cgi/content/short/10/3/e001686?rss=1

Source: Circulation: Cardiovascular Genetics - June 9, 2017 Category: Cardiology Authors: Mellor, G., Laksman, Z. W. M., Tadros, R., Roberts, J. D., Gerull, B., Simpson, C. S., Klein, G. J., Champagne, J., Talajic, M., Gardner, M., Steinberg, C., Arbour, L., Birnie, D. H., Angaran, P., Leather, R., Sanatani, S., Chauhan, V. S., Seifer, C., Hea Tags: Sudden Cardiac Death, Ventricular Fibrillation, Clinical Studies, Genetics Original Articles Source Type: research