Hyaluronidase 2 Deficiency Causes Increased Mesenchymal Cells, Congenital Heart Defects, and Heart Failure [Original Articles]

Conclusions—
These data demonstrate that disruption of normal HA catabolism in Hyal2–/– mice causes increased HA, which may promote endothelial-to-mesenchymal transition and proliferation of mesenchymal cells. Excess endothelial-to-mesenchymal transition, resulting in increased mesenchymal cells, is the likely cause of morphological heart abnormalities in both humans and mice. In mice, these abnormalities result in progressive and severe diastolic dysfunction, culminating in heart failure.

Source: Circulation: Cardiovascular Genetics - February 13, 2017 Category: Cardiology Authors: Chowdhury, B., Xiang, B., Liu, M., Hemming, R., Dolinsky, V. W., Triggs-Raine, B. Tags: Basic Science Research, Developmental Biology, Fibrosis, Genetically Altered and Transgenic Models, Heart Failure Original Articles Source Type: research