Genome-Wide Prioritization and Transcriptomics Reveal Novel Signatures Associated With Thiazide Diuretics Blood Pressure Response [Original Articles]

Conclusions— This study highlights the strength of using different omics to identify novel biomarkers of drug response and suggests VASP as a potential determinant of thiazide diuretics BP response. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifiers: NCT00246519 and NCT01203852.

http://circgenetics.ahajournals.org/cgi/content/short/10/1/e001404?rss=1

Source: Circulation: Cardiovascular Genetics - January 22, 2017 Category: Cardiology Authors: Shahin, M. H., Sa, A. C., Webb, A., Gong, Y., Langaee, T., McDonough, C. W., Riva, A., Beitleshees, A. L., Chapman, A. B., Gums, J. G., Turner, S. T., Boerwinkle, E., Scherer, S. E., Sadee, W., Cooper-DeHoff, R. M., Johnson, J. A. Tags: Gene Expression & Regulation, Genetic, Association Studies, Genetics, High Blood Pressure, Hypertension Original Articles Source Type: research