Screening of the Filamin C Gene in a Large Cohort of Hypertrophic Cardiomyopathy Patients [Original Article]

Conclusions— We provide a compelling evidence of the involvement of FLNC in the development of HCM. Most of the FLNC variants were associated with mild forms of HCM and a reduced penetrance, with few affected in the families to confirm the segregation. Our work, together with others who found FLNC variants among patients with dilated and restrictive cardiomyopathies, pointed to this gene as an important cause of structural cardiomyopathies.
Source: Circulation: Cardiovascular Genetics - Category: Cardiology Authors: Tags: Genetics, Hypertrophy Original Article Source Type: research