Genome-Wide Association Studies and Meta-Analyses for Congenital Heart Defects [Original Articles]

Conclusions—
We identified 1 novel candidate region associated with LVOTDs and report on several additional regions with suggestive evidence for association with CTD and LVOTD. These studies were constrained by the relatively small samples sizes and thus have limited power to detect small to moderate associations. Approaches that minimize the multiple testing burden (eg, gene or pathway based) may, therefore, be required to uncover common variants contributing to the risk of these relatively rare conditions.

Source: Circulation: Cardiovascular Genetics - May 3, 2017 Category: Cardiology Authors: Agopian, A. J., Goldmuntz, E., Hakonarson, H., Sewda, A., Taylor, D., Mitchell, L. E., Pediatric Cardiac Genomics Consortium* Tags: Epidemiology, Genetic, Association Studies, Functional Genomics, Congenital Heart Disease Original Articles Source Type: research