Arquivos Brasileiros de Endocrinologia e Metabologia 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Evaluation of fructosamine as a parameter of blood glucose control in diabetic pregnant women
Conclusion The levels of fructosamine can be used as further parameter to aid self monitoring of blood glucose to evaluate hyperglycemias and glycemic variability, however, this can underestimate hypoglycemias in pregnant women carrying small-for-gestational age fetuses. (Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 4, 2014 Category: Endocrinology Source Type: research
The prevalence of glucose metabolism disturbances in Chinese Muslims and possible risk factors: a study from northwest China
Conclusions In northwest China, the prevalence of DM was higher in the Muslim population, and it was special higher on the 20-year-old age compared to the Han. This might be explained by the potential genetic differences and poor dietary habits. Objetivo Avaliar a prevalência de diabetes melito (DM) e pré-diabetes melito (PDM) na população muçulmana no noroeste da China e discutir os fatores de risco. Materiais e métodos Selecionamos três vilarejos de acordo com a renda e a população, usando uma amostra estratificada e por cluster. Os sujeitos eram residentes com ≥ 20 anos de idade e de famÃlias que estav...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 4, 2014 Category: Endocrinology Source Type: research
Serum levels of retinol binding protein 4 in women with different levels of adiposity and glucose tolerance
Conclusions Although RBP4 have shown lower levels in diabetic and obese, a strong correlation with HOMA-IR index highlights that, in our study, there is growing IR when there is an increasing in RBP4 levels. Objetivo A proteÃna carreadora do retinol 4 (RBP4) é uma adipocina responsável pelo transporte de vitamina A (retinol). Estudos associam os nÃveis aumentados de RBP4 com a gravidade do diabetes melito tipo 2 (DM2) e resistência à insulina (RI). O objetivo deste estudo foi investigar como esses nÃveis se comportam em mulheres com ampla variação do Ãndice de massa corporal (IMC) e tolerância à glicose. Suj...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 4, 2014 Category: Endocrinology Source Type: research
The role of imaging in congenital adrenal hyperplasia
Congenital adrenal hyperplasia (CAH) is an autossomic recessive disorder caused by impaired steroidogenesis. Patients with CAH may present adrenal insufficiency with or without salt-wasting, as well as various degrees of virilization and fertility impairment, carrying a high incidence of testicular adrenal rest tumors and increased incidence of adrenal tumors. The diagnosis of CAH is made based on the adrenocortical profile hormonal evaluation and genotyping, in selected cases. Follow-up is mainly based on hormonal and clinical evaluation. Utility of imaging in this clinical setting may be helpful for the diagnosis, manage...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 4, 2014 Category: Endocrinology Source Type: research
Diagnosis, treatment, and follow-up of medullary thyroid carcinoma: recommendations by the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism
Conclusions 7 (Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 4, 2014 Category: Endocrinology Source Type: research
Persistence of intrasellar trigeminal artery and simultaneous pituitary adenoma: description of two cases and their importance for the differential diagnosis of sellar lesions
Persistent trigeminal artery (PTA) is the most frequent embryonic communication between the carotid and vertebrobasilar systems. However, hormonal changes or the association of PTA with other sellar lesions, such as pituitary adenomas, are extremely rare. The aim of the present study was to report two patients with intrasellar PTA and simultaneous pituitary adenoma in order to emphasize the importance of differential diagnoses for sellar lesions. Case 1. A female patient, 41 years old, was admitted with a history of chronic headache (> 20 years). Pituitary magnetic resonance imaging (MRI) showed a rounded lesion in the ...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 10, 2014 Category: Endocrinology Source Type: research
Aggressive pituitary lesion with a remarkably high Ki-67
The uncommon aggressive pituitary tumors are named carcinomas when metastases are detected, either in the central nervous system and/or systemically. Some cases are associated with hormonal overproduction, but most are diagnosed because of local symptoms. These neoplasias are generally refractory to current treatments. A 51 year-old woman presented sudden onset of headache, left arm paresis and left facial hypoesthesia. Computed tomography scan and magnetic resonance imaging revealed a pituitary tumor invading the left sphenoidal and cavernous sinuses. Laboratory data excluded hormonal hypersecretion. The patient underwent...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 10, 2014 Category: Endocrinology Source Type: research
3?-hydroxysteroid dehydrogenase type II deficiency on newborn screening test
We present the first report of 3β-HSD type II deficiency genotype-proven detected at the Newborn Screening Program in Brazil. The case described herein corroborates the strong genotype-phenotype correlation associated with the HSD3B2 p.P222Q mutation, which leads to a classic salt-wasting 3β-HSD deficiency. Further evaluation of 17OHP assays used in newborn screening tests would aid in determining their reproducibility, as well as the potential significance of moderately elevated 17OHP levels as an early indicator to the diagnosis of other forms of classic CAH, beyond 21-hydroxylase deficiency.A deficiência da enzima 3Î...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 10, 2014 Category: Endocrinology Source Type: research
Rare association between penile squamous cell carcinoma and parathyroid related peptide (PTH-rP) secretion
We report on a rare case of an adult with severe hypercalcemia secondary to the ectopic secretion of parathyroid-related peptide (PTH-rP) from a penile squamous cell cancer (PC). A patient of 47 years old was admitted with warty lesions and areas of ulceration covered by purulent material in a large area of the groin, scrotum and penis. Laboratory tests revealed severe hypercalcemia and elevation of PTH-rP; the biopsy reported PC. Hypercalcemia was successfully treated with zoledronic acid, however, the tumor displayed aggressive behavior, which resulted in a poor prognosis for the patient.Relatamos um caso raro em um adul...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 10, 2014 Category: Endocrinology Source Type: research
Lack of association between polymorphisms in the UBASH3A gene and autoimmune thyroid disease: a case control study
Conclusion: Rs11203203 and rs3788013 in UBASH3A gene may not be associated with AITD patients in Chinese Han population. Objetivo: O objetivo deste estudo foi investigar a variação no gene UBASH3A com a doença tiroidiana autoimune e caracterÃsticas clÃnicas na população chinesa Han. Sujeitos e métodos: Um total de 667 pacientes com DTAI (417 com DG e 250 com TH) e 301 controles saudáveis foi genotipado para dois polimorfismos de nucleotÃdeo simples (SNPs) rs11203203, rs3788013 do gene UBASH3A, usando-se a plataforma MALDI-TOF-MS (Ionização/Dessorção de Matriz Assistida por Laser – Tempo de Voo/Espectr...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 10, 2014 Category: Endocrinology Source Type: research
Hydrochloride pioglitazone protects diabetic rats against podocyte injury through preserving glomerular podocalyxin expression
Conclusion: PIO could alleviate diabetic kidney injury in a dose-dependent pattern and the role may be associated with restraining urinary sediment podocalyxin excretion and preserving the glomerular podocalyxin expression. Objetivo: Buscamos testar os efeitos de diferentes doses de pioglitazona (PIO) sobre a expressão glomerular de podocalixina e sobre a excreção de podocalixina em células do sedimento urinário, além de explorar o potencial mecanismo de proteção renal. Materiais e métodos: O diabetes tipo 1 foi induzido em 36 ratos Sprague-Dawley machos com estreptozotocina (65 mg/kg). Os animais foram trat...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 10, 2014 Category: Endocrinology Source Type: research
Screening of celiac disease in patients with autoimmune thyroid disease from Southern Brazil
Conclusion: We found a prevalence of 1.2% (1:85) of confirmed CD among Brazilian patients with ATD. Although some IgA-EmA positive patients had Graves’ disease and one was male, all three patients with confirmed CD were female and had Hashimoto’s thyroiditis. Arq Bras Endocrinol Metab. 2014;58(6):625-9 Objetivo: O objetivo do presente estudo foi determinar a prevalência de doença celÃaca (DC) em adultos com doenças autoimunes de tireoide (DAT) que foram atendidos em um serviço de endocrinologia de um hospital universitário do sul do Brasil. Sujeitos e métodos: Entre os anos de 2007 a 2011, 254 pacientes co...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 10, 2014 Category: Endocrinology Source Type: research
Evaluation of parathyroid function and mineral metabolism in psychiatric patients using lithium salts
Conclusion: Our data demonstrate that lithium may create an imbalance in the parathyroid axis, characterized by elevated levels of PTH. Objetivo: Avaliar a função paratireoidiana e o metabolismo mineral em pacientes psiquiátricos usuários de sais de lÃtio. Materiais e métodos: Foram avaliados os nÃveis séricos de cálcio total, cálcio iônico, fósforo inorgânico, fosfatase alcalina, albumina, paratormônio (PTH), ureia, creatinina, 25-hidroxivitamina D e lÃtio de 35 pacientes diagnosticados com transtorno afetivo bipolar usuários de carbonato de lÃtio (CL) há pelo menos um ano (Grupo LÃtio – GL) e 3...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 10, 2014 Category: Endocrinology Source Type: research
Insulin resistance and components of metabolic syndrome, analysis by gender and stage of adolescence
Conclusions: Insulin resistance is associated with inadequate body composition, in biochemical levels and lifestyle, being the factors associated different in each phase of adolescence. Arq Bras Endocrinol Metab. 2014;58(6):610-8 (Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 10, 2014 Category: Endocrinology Source Type: research
Obesity, insulin resistance and comorbidities ? Mechanisms of association
Overall excess of fat, usually defined by the body mass index, is associated with metabolic (e.g. glucose intolerance, type 2 diabetes mellitus (T2DM), dyslipidemia) and non-metabolic disorders (e.g. neoplasias, polycystic ovary syndrome, non-alcoholic fat liver disease, glomerulopathy, bone fragility etc.). However, more than its total amount, the distribution of adipose tissue throughout the body is a better predictor of the risk to the development of those disorders. Fat accumulation in the abdominal area and in non-adipose tissue (ectopic fat), for example, is associated with increased risk to develop metabolic and non...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 10, 2014 Category: Endocrinology Source Type: research
