Arquivos Brasileiros de Endocrinologia e Metabologia 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Serum uric acid levels and non-alcoholic fatty liver disease in Uyghur and Han ethnic groups in northwestern China
CONCLUSIONS: Serum uric acid is an independent risk factor in nonalcoholic fatty liver disease in both Uyghurs and Hans, but other risk factors may be more important in the differences in prevalence of the disease between the two ethnic groups.OBJETIVO: O objetivo deste estudo foi comparar os valores de ácido úrico em duas populações chinesas etnicamente diferentes: Uyghur, com alta prevalência de doença hepática gordurosa não alcoólica, e Han, com prevalência mais baixa. SUJEITOS E MÉTODOS: A concentração sérica de ácido úrico e várias caracterÃsticas clÃnicas e testes laboratoriais relevantes para a sÃ...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - December 17, 2013 Category: Endocrinology Source Type: research
Frequency of various types of neoplasia in a group of acromegalic patients
CONCLUSION: Although a small number of acromegalic patients was studied, our findings confirm the high frequency of thyroid neoplasias and primary hyperparathyroidism in this group of patients.OBJETIVO: Determinar a frequência de câncer de cólon, hiperparatireoidismo primário, tumores de tireoide e pele em todos os acromegálicos em seguimento no Hospital de ClÃnicas da Faculdade de Medicina de Botucatu de 2005 a 2011. SUJEITOS E MÉTODOS: Esses pacientes foram avaliados retrospectivamente quanto a presença de câncer de cólon, hiperparatiroidismo primário, tumores da tiroide e pele. RESULTADOS: Dos 29 pacientes in...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - December 17, 2013 Category: Endocrinology Source Type: research
Polymorphisms in LEPR, PPARG and APM1 genes: associations with energy intake and metabolic traits in young children
CONCLUSIONS: Two of the six studied SNPs presented consistent associations, showing that it is already possible to detect the influences of genetic variants on susceptibility to overweight in 4-year-old children.OBJETIVO: Avaliar a associação de polimorfismos de nucleotÃdeo único (SNPs) em cinco genes: leptina, receptor da leptina (LEPR), adiponectina (APM1), receptor ativado por proliferadores de peroxissomas gama (PPARG) e proteÃna desacopladora 1 com parâmetros antropométricos, metabólicos e dietéticos em uma coorte sul-brasileira composta por 325 crianças acompanhadas desde o nascimento até os 4 anos. MATERI...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - December 17, 2013 Category: Endocrinology Source Type: research
Interval training attenuates the metabolic disturbances in type 1 diabetes rat model
CONCLUSION: Low-volume high-intensity physical exercise attenuates hyperglycemia and dislipidemia induced by type 1 diabetes, and induces changes in the functionality of innate and acquired immunity.OBJETIVO: Este estudo investigou os efeitos do treinamento intervalado sobre parâmetros bioquÃmicos e imunológicos em ratos diabéticos do tipo 1. MATERIAIS E MÉTODOS: Ratos Wistar machos foram divididos em quatro grupos: sedentário (SE, n = 15), treinamento intervalado (TI, n = 17), sedentário diabético (SED, n = 17) e treinamento intervalado diabético (TID, n = 17). O diabetes foi induzido por uma injeção intravenos...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - December 17, 2013 Category: Endocrinology Source Type: research
Biochemical, hormonal and genetic evaluation of the families of two Brazilian patients with type 2 familial partial lipodystrophy
CONCLUSION: A mutation in the LMNA gene is a determinant of clinical, biochemical and hormonal changes that imply in metabolic deterioration in mutation carriers. (Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - December 17, 2013 Category: Endocrinology Source Type: research
Diagnosis and treatment of Paget's disease of bone: a mini-review
Paget's disease of bone (PDB) is a chronic progressive disorder of bone metabolism that may go undetected for many years, and endocrinologists should be alert to its clinical signs and promptly diagnose and treat PDB before it results in irreversible complications, such as deformity, fracture or neurological sequelae. Most commonly, PDB is suspected upon the incidental finding of elevated serum alkaline phosphatase levels or a radiographic abnormality in an otherwise healthy individual above 55 years of age. Some of these individuals may have symptoms such as bone pain or enlargement with increased warmth. In general, a ba...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - December 17, 2013 Category: Endocrinology Source Type: research
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(Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 18, 2013 Category: Endocrinology Source Type: research
Response to the letter: endocrine disturbances related to the use of lithium
Intracranial germinomas (GE) are malignant neoplasms most commonly found in the suprasellar region, which may cause anterior and particularly posterior pituitary hormone deficits with central diabetes insipidus (DI). Differential diagnosis of pituitary stalk thickening includes granulomatous, inflammatory, infectious, and neoplastic lesions. Although careful analysis of clinical, laboratory, and imaging findings may facilitate the diagnosis, transsphenoidal biopsy is indicated to confirm the disease, as the correct diagnosis directs the appropriate treatment.Germinomas intracranianos (GE) são neoplasias malignas comumente...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 18, 2013 Category: Endocrinology Source Type: research
Lithium and phosphorilation cell reactions
Intracranial germinomas (GE) are malignant neoplasms most commonly found in the suprasellar region, which may cause anterior and particularly posterior pituitary hormone deficits with central diabetes insipidus (DI). Differential diagnosis of pituitary stalk thickening includes granulomatous, inflammatory, infectious, and neoplastic lesions. Although careful analysis of clinical, laboratory, and imaging findings may facilitate the diagnosis, transsphenoidal biopsy is indicated to confirm the disease, as the correct diagnosis directs the appropriate treatment.Germinomas intracranianos (GE) são neoplasias malignas comumente...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 18, 2013 Category: Endocrinology Source Type: research
An intrasellar germinoma with normal tumor marker concentrations mimicking primary lymphocytic hypophysitis
Intracranial germinomas (GE) are malignant neoplasms most commonly found in the suprasellar region, which may cause anterior and particularly posterior pituitary hormone deficits with central diabetes insipidus (DI). Differential diagnosis of pituitary stalk thickening includes granulomatous, inflammatory, infectious, and neoplastic lesions. Although careful analysis of clinical, laboratory, and imaging findings may facilitate the diagnosis, transsphenoidal biopsy is indicated to confirm the disease, as the correct diagnosis directs the appropriate treatment.Germinomas intracranianos (GE) são neoplasias malignas comumente...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 18, 2013 Category: Endocrinology Source Type: research
Mild adrenal insufficiency due to a NROB1 (DAX1) gene mutation in a boy presenting an association of hypogonadotropic hypogonadism, reduced final height and attention deficit disorder
Mutation on NROB1 (DAX1) gene can cause different phenotypes of adrenal insufficiency in infancy. Long-term evolution of these patients shows that it is possible to have an association with hypogonadotropic hypogonadism. In this article we describe the evolution of a patient with NROB1 gene mutation, diagnosed with a mild form of adrenal insufficiency, and we highlight the presence of hypogonadotropic hypogonadism and short stature, besides the presence of attention deficit disorder. Such associations should make physicians aware during the follow-up of patients with this disease.Mutações no gene NROB1 (DAX1) podem levar...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 18, 2013 Category: Endocrinology Source Type: research
Giant macroprolactinoma and pregnancy
We present the case of a 38-year-old woman with history of amenorrhea and infertility. At seven weeks of pregnancy she presented neuro-ophthalmologic complaints of headaches, diplopia, and right ptosis. The work-up study revealed an invasive pituitary macroadenoma with a maximum diameter of 9 cm and serum prolactin of 25,800 ng/mL (3-20). At 12 weeks, she was referred to the Endocrinology Department of the Coimbra University Hospital and started therapy with bromocriptine, initially 5 mg/day and then at crescent doses. Hyperprolactinemia was rapidly and drastically reduced to 254 ng/mL three weeks after taking bromocriptin...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 18, 2013 Category: Endocrinology Source Type: research
Physical activities in daily life and functional capacity compared to disease activity control in acromegalic patients: impact in self-reported quality of life
CONCLUSIONS: In this study, the presence and severity of physical disability and pain were not associated with initial GH and IGF-1 levels or time of exposure to GH excess. However, the patients considered controlled, with normal a normal age-adjusted IGF-1, presented higher scores in SF-36, in physical and emotional domains, compared with patients with persistent hypersomatotrophism. These findings suggest benefits of metabolic control in self-reported quality of life.OBJETIVO: Avaliar a qualidade de vida e sua associação com a prática de vida diária e controle metabólico em pacientes portadores de acromegalia. SUJEI...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 18, 2013 Category: Endocrinology Source Type: research
Diabetes: time to redefine goals?
CONCLUSIONS: Besides recommending different A1c goals for different patients, the SBD should probably review its recommendations and adopt different blood glucose goals that are compatible with the proposed A1c goals, making therapeutic targets clearer. (Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 18, 2013 Category: Endocrinology Source Type: research
Evolution of thyroid cancer mortality in adults in Brazil
CONCLUSION: Knowledge about trends allows setting priorities and allocating resources toward positive changes in this scenario in the Brazilian population.OBJETIVO: Avaliar a tendência da mortalidade por câncer de tireoide no Brasil entre 1980 e 2010. MATERIAIS E MÉTODOS: Estudo ecológico, de séries temporais. As taxas de mortalidade por câncer de tireoide ajustadas por idade segundo sexo foram calculadas entre 1980 e 2010. Os dados foram analisados por três estratégias distintas: regressão polinomial, joinpoint analysis e médias móveis. RESULTADOS: Mais de 70% das mortes ocorrem nos idosos, independente do sexo...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 18, 2013 Category: Endocrinology Source Type: research
