Butyrylcholinesterase activity and cardiovascular risk factors in obese adolescents submitted to an exercise program
CONCLUSION: The reduction in BChE activity, observed after physical exercise, was accompanied by the reduction of the variables associated with cardiovascular risk and obesity, indicating that BChE can be used as a secondary marker for the risk associated with early onset obesity. (Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 18, 2013 Category: Endocrinology Source Type: research

Evaluation of bone mineral density in female adolescents with eating disorders
CONCLUSION: The recovery of BMD does not occur together with the restoration of hypothalamic-pituitary-gonadal axis. (Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 18, 2013 Category: Endocrinology Source Type: research

Obesity: main risk factor for systemic arterial hypertension in Brazilian adolescents from a cohort study
CONCLUSION: The results show an association between obesity and hypertension among adolescents. (Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 18, 2013 Category: Endocrinology Source Type: research

Influence of PPARA, RXRA, NR1I2 and NR1I3 gene polymorphisms on the lipid-lowering efficacy and safety of statin therapy
CONCLUSION: The polymorphisms investigated in PPARA (rs1800206), RXRA (rs11381416), and NR1I2 (rs1523130) did not influence the lipid-lowering efficacy and safety of statin. Our results show the possible influence of NR1I3 genetic variant on the safety of statin.OBJETIVO: O objetivo deste estudo foi investigar a associação de seis variantes genéticas nos genes de receptores nucleares PPARA, RXRA, NR1I2 e NR1I3 na eficácia hipolipemiante e na segurança da terapia com estatinas. SUJEITOS E MÉTODOS: O estudo foi realizado com 240 pacientes hipercolesterolêmicos em terapia com sinvastina e atorvastatina. Os polimorfismo...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 18, 2013 Category: Endocrinology Source Type: research

Prevalence of vitamin D deficiency is higher in patients with Paget's disease of bone compared with age-matched controls
CONCLUSION: These results suggest a high prevalence of hypovitaminosis D in patients with Paget's disease living in the tropics.OBJETIVO: Investigar se a deficiência de vitamina D é mais prevalente nos pacientes com doença de Paget óssea (DPO) do que em controles equiparados pela idade. SUJEITOS E MÉTODOS: Neste estudo retrospectivo avaliamos a 25-OHD em 28 pacientes não tratados com DPO e dois grupos controle: 284 homens idosos de uma coorte de nosso departamento e 151 mulheres na pós-menopausa atendidas em nosso ambulatório para avaliação médica de rotina. RESULTADOS: A média ± DP da 25-OHD foi significativa...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 18, 2013 Category: Endocrinology Source Type: research

Translational research in gestational diabetes mellitus and mild gestational hyperglycemia: current knowledge and our experience
O diabetes materno constitui um ambiente desfavorável para o desenvolvimento embrionário e feto-placentário. É uma repercussão de importância na obstetrícia moderna, visto que está associado a um risco aumentado de morbidade materna e neonatal e continua a ser um desafio médico significativo. O aumento mundial na incidência do diabetes, o aumento do diabetes tipo 2 em mulheres em idade reprodutiva e a geração cruzada da programação intrauterina do diabetes tipo 2 são as bases para o interesse crescente na utilização de modelos experimentais diabéticos, a fim de obter conhecimento sobre os mecanismos que i...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 18, 2013 Category: Endocrinology Source Type: research

Response to the letter: Is there a higher cardiovascular disease risk in Japanese-Brazilians?
Cushing's disease (CD) is usually caused by secretion of ACTH by a pituitary corticotroph microadenoma. Nevertheless, 7%-20% of patients present with ACTH-secreting macroadenomas. Our aim is to report a 36-year-old female patient with CD due to solid-cystic ACTH-macroadenoma followed up during 34 months. The patient presented spontaneous remission due to presumed asymptomatic tumor apoplexy. She showed typical signs and symptoms of Cushing's syndrome (CS). Initial tests were consistent with ACTH-dependent CS: elevated urinary free cortisol, abnormal serum cortisol after low dose dexamethasone suppression test, and elevated...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 16, 2013 Category: Endocrinology Source Type: research

Is there a higher cardiovascular disease risk in Japanese-Brazilians?
Cushing's disease (CD) is usually caused by secretion of ACTH by a pituitary corticotroph microadenoma. Nevertheless, 7%-20% of patients present with ACTH-secreting macroadenomas. Our aim is to report a 36-year-old female patient with CD due to solid-cystic ACTH-macroadenoma followed up during 34 months. The patient presented spontaneous remission due to presumed asymptomatic tumor apoplexy. She showed typical signs and symptoms of Cushing's syndrome (CS). Initial tests were consistent with ACTH-dependent CS: elevated urinary free cortisol, abnormal serum cortisol after low dose dexamethasone suppression test, and elevated...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 16, 2013 Category: Endocrinology Source Type: research

Perspectives in isolation of microRNA from thyroid fine-needle aspiration: reply to the letter "Nucleic acid recovery from thyroid fine-needle cytology slides"
Cushing's disease (CD) is usually caused by secretion of ACTH by a pituitary corticotroph microadenoma. Nevertheless, 7%-20% of patients present with ACTH-secreting macroadenomas. Our aim is to report a 36-year-old female patient with CD due to solid-cystic ACTH-macroadenoma followed up during 34 months. The patient presented spontaneous remission due to presumed asymptomatic tumor apoplexy. She showed typical signs and symptoms of Cushing's syndrome (CS). Initial tests were consistent with ACTH-dependent CS: elevated urinary free cortisol, abnormal serum cortisol after low dose dexamethasone suppression test, and elevated...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 16, 2013 Category: Endocrinology Source Type: research

Nucleic acid recovery from thyroid fine-needle cytology slides
Cushing's disease (CD) is usually caused by secretion of ACTH by a pituitary corticotroph microadenoma. Nevertheless, 7%-20% of patients present with ACTH-secreting macroadenomas. Our aim is to report a 36-year-old female patient with CD due to solid-cystic ACTH-macroadenoma followed up during 34 months. The patient presented spontaneous remission due to presumed asymptomatic tumor apoplexy. She showed typical signs and symptoms of Cushing's syndrome (CS). Initial tests were consistent with ACTH-dependent CS: elevated urinary free cortisol, abnormal serum cortisol after low dose dexamethasone suppression test, and elevated...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 16, 2013 Category: Endocrinology Source Type: research

Spontaneous remission of hypercortisolism presumed due to asymptomatic tumor apoplexy in ACTH-producing pituitary macroadenoma
Cushing's disease (CD) is usually caused by secretion of ACTH by a pituitary corticotroph microadenoma. Nevertheless, 7%-20% of patients present with ACTH-secreting macroadenomas. Our aim is to report a 36-year-old female patient with CD due to solid-cystic ACTH-macroadenoma followed up during 34 months. The patient presented spontaneous remission due to presumed asymptomatic tumor apoplexy. She showed typical signs and symptoms of Cushing's syndrome (CS). Initial tests were consistent with ACTH-dependent CS: elevated urinary free cortisol, abnormal serum cortisol after low dose dexamethasone suppression test, and elevated...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 16, 2013 Category: Endocrinology Source Type: research

Horner syndrome as a manifestation of thyroid carcinoma: a rare association
An 82-year-old patient presented a progressively growing hard thyroid nodule, and left ptosis. Additionally, ophthalmologic evaluation revealed ipsilateral miosis, diagnostic findings of Horner syndrome. Computerized tomography revealed a 7.5-cm thyroid mass infiltrating the main neck vessels. Although clinical and imaging data were suggestive of poorly differentiated thyroid carcinoma, fine-needle aspiration led to the diagnosis of papillary carcinoma. Paliative care was proposed to the patient due to the advanced stage of the neoplasm and to significant comorbidities. Horner syndrome is an infrequent manifestation of thy...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 16, 2013 Category: Endocrinology Source Type: research

Iodine nutrition in elementary state schools of Queretaro, Mexico: correlations between urinary iodine concentration with global nutrition status and social gap index
CONCLUSIONS: There is coexistence between the two extremes of iodine intake (insufficient and excessive). To our knowledge, the observed positive correlation between UIC and overweight and obesity has not been described before, and could be explained by the availability and consumption of snack food rich in energy and iodized salt.OBJETIVO E MÉTODOS: Estimar a concentração de iodo urinário (CIU) mediana e correlacioná-la com os indicadores de nutrição geral e com o índice de desigualdade social (IDS) de 50 escolas estaduais de ensino fundamental de 10 municípios do estado de Querétaro, no México. RESULTADOS: Uti...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 16, 2013 Category: Endocrinology Source Type: research

Association of processed meat intake and obesity in a population-based study of Japanese-Brazilians
CONCLUSION: Our results showed that high intakes of processed meats were associated with overall with abdominal obesity in male Japanese-Brazilians, but not in females. (Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 16, 2013 Category: Endocrinology Source Type: research

Parameters of glycemic control in type 2 diabetic patients on hemodialysis or peritoneal dialysis: implications for clinical practice
CONCLUSION: Similar HbA1c values in PD patients may correspond to greater levels of AG than in HD or NRF patients.OBJETIVO: Para melhor explorar a relação entre os parâmetros de controle glicêmico em DM2 em TRS, estudamos 23 pacientes em hemodiálise (HD), 22 em diálise peritoneal (DP) em comparação à 24 DM2 com função renal normal (FRN). MATERIAIS E MÉTODOS: Em quatro dias consecutivos, realizamos 10 glicemias capilares [4 em jejum, 2 pré- e 4 pós-prandiais (G-pós) e a média glicêmica (MG)], glicemia aleatória e HbA1c em todos os pacientes. RESULTADOS: As glicemias pré-prandiais foram mais elevadas nos p...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 16, 2013 Category: Endocrinology Source Type: research