Arquivos Brasileiros de Endocrinologia e Metabologia 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Sarcopenia
, the loss of muscle mass and function with age, is highly relevant to clinical practice as it has been associated with a wide range of ageing outcomes including disability and shorter survival times. As such it is now a major focus for research and drug discovery. There has been recent progress in the development of consensus definitions for the diagnosis of sarcopenia, taking the form of measurements of muscle mass and strength or physical performance. These definitions form potential inclusion criteria for use in trials, although the optimum choice of outcome measures is less clear. Prevalence estimates using these new ...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - August 22, 2014 Category: Endocrinology Source Type: research
The multiple effects of thyroid disorders on bone and mineral metabolism
We present here a thorough review of the action of TH on bone and of the impact of thyroid disorders, including hyper- and hypothyroidism and the syndrome of TH resistance, on the skeleton.Diferentemente da maioria dos hormônios, que usualmente são moléculas especializadas capazes de influenciar outras células, tecidos e sistemas, os hormônios da tireoide (HT) são peptídeos pleiotrópicos, cuja função primordial é difícil de identificar. A ação complexa dos HT na fisiologia humana pode ser facilmente reconhecida ao observar as diversas consequências do excesso e da deficiência de HT durante e após o pleno d...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - August 22, 2014 Category: Endocrinology Source Type: research
Osteocalcin, energy and glucose metabolism
Osteocalcin is a bone matrix protein that has been associated with several hormonal actions on energy and glucose metabolism. Animal and experimental models have shown that osteocalcin is released into the bloodstream and exerts biological effects on pancreatic beta cells and adipose tissue. Undercarboxylated osteocalcin is the hormonally active isoform and stimulates insulin secretion and enhances insulin sensitivity in adipose tissue and muscle. Insulin and leptin, in turn, act on bone tissue, modulating the osteocalcin secretion, in a traditional feedback mechanism that places the skeleton as a true endocrine organ. Fur...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - August 22, 2014 Category: Endocrinology Source Type: research
The burden of osteoporosis in Brazil
This article reviews the Brazilian burden of osteoporosis in terms of the prevalence and fractures attributable to the disease, the costs related to the investigation and management, as well as the impact of osteoporosis on the population as a whole and on affected individuals.Fraturas osteoporóticas impõem graves entraves físicos, psicossociais e financeiros, tanto para o paciente quanto para a sociedade. Estudos sobre a prevalência de osteoporose e fraturas por fragilidade no Brasil mostram uma grande variação, em decorrência das diferenças no tamanho das amostras, da população estudada e da metodologia emprega...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - August 22, 2014 Category: Endocrinology Source Type: research
Recommendations of the Brazilian Society of Endocrinology and Metabology (SBEM) for the diagnosis and treatment of hypovitaminosis D
Conclusion A scientific update regarding hypovitaminosis D was presented to serve as the basis for the diagnosis and treatment of this condition in Brazil. (Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - August 22, 2014 Category: Endocrinology Source Type: research
Targets in osteoporosis treatment
(Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - August 22, 2014 Category: Endocrinology Source Type: research
Sensor-augmented pump and Down syndrome: a new tool in tricky patients
We report a case of a 60-year-old woman presenting an 8-month history of enlargement of the neck associated with dysphagia. The patient underwent a right hemithyroidectomy and SFT of the thyroid was diagnosed. Immunohistochemistry showed positivity for CD34 marker, and the high number of mitoses and the presence of cellular atypia suggested that the tumor was malignant. To our knowledge, this is the second case of malignant SFT of the thyroid gland ever reported. Due to the rarity of these tumors, the indication of adjuvant therapy and prognosis are uncertain. Long-term follow-up after surgical resection seems to be advisa...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - June 17, 2014 Category: Endocrinology Source Type: research
Malignant solitary fibrous tumor of the thyroid: a case-report and review of the literature
We report a case of a 60-year-old woman presenting an 8-month history of enlargement of the neck associated with dysphagia. The patient underwent a right hemithyroidectomy and SFT of the thyroid was diagnosed. Immunohistochemistry showed positivity for CD34 marker, and the high number of mitoses and the presence of cellular atypia suggested that the tumor was malignant. To our knowledge, this is the second case of malignant SFT of the thyroid gland ever reported. Due to the rarity of these tumors, the indication of adjuvant therapy and prognosis are uncertain. Long-term follow-up after surgical resection seems to be advisa...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - June 17, 2014 Category: Endocrinology Source Type: research
An uncommon case of Marine-Lenhart syndrome
We describe here the case of a female patient with Graves’ disease who was successfully treated with radioiodine for Graves’ disease, returning to normal thyroid function. Three years later, biochemical analysis and ultrasound examination identified a thyroid nodule that progressively increased in size. The 99mTc-pertechnetate scintigraphy showed avid uptake in the right lobule, which corresponded to a nodular lesion consistent with AFTN.O termo “síndrome de Marine-Lenhart” descreve a associação da doença de Graves e nódulos tireoidianos de funcionamento autônomo (AFTN), como no adenoma tóxico ou bócio mul...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - June 17, 2014 Category: Endocrinology Source Type: research
The importance of memory bias in obtaining age of menarche by recall method in Brazilian adolescents
Conclusion: The age at menarche obtained by the recall method was similar for girls who menstruated within the previous 3 years (and approaches the age calculated by logit); when more than 3 years have passed, the recall bias was significant. (Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - June 17, 2014 Category: Endocrinology Source Type: research
TSH reference range in older adults: a Brazilian study
Conclusion: This study suggests an upper limit for normal TSH of approximately 4.6 mIU/L for the Brazilian elderly population. Objetivo: Estabelecer os valores de referência do TSH sérico em uma população idosa brasileira e compará-los ao encontrado na população adulta. Sujeitos e métodos: Foram selecionados voluntários saudáveis; com idade entre 70 e 85 anos; sem doença tireoidiana conhecida ou fatores de risco para disfunção tireoidiana; sem uso de medicamentos potencialmente interferentes no TSH. Indivíduos com bócio, nódulo tireoidiano palpável, anticorpos antitireoperoxidase ou T4 livre alterado f...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - June 17, 2014 Category: Endocrinology Source Type: research
The rs1893217 (T/C) polymorphism in PTPN2 gene is not associated with type 1 diabetes mellitus in subjects from Southern Brazil
Conclusion: The PTPN2 rs1893217 polymorphism is not significantly associated with T1DM in Caucasian subjects from Southern Brazil. Objetivo: Avaliar a associação do polimorfismo rs1893217 no gene PTPN2 com DM1 e/ou suas características clínicas e laboratoriais em uma população de brancos do Sul do Brasil. Sujeitos e métodos: Quatrocentos e oitenta e seis pacientes com DM1 e 484 indivíduos não diabéticos foram incluídos no estudo. A genotipagem do PTPN2 rs1893217 foi realizada por PCR em tempo real. Resultados: As frequências genotípicas não diferiram entre os pacientes com DM1 e indivíduos não diabéti...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - June 17, 2014 Category: Endocrinology Source Type: research
Fasting ghrelin but not PYY(3-36) is associated with insulin-resistance independently of body weight in Wistar rats
Conclusion: Fasting ghrelin and PYY serum levels are increased in lean, relatively insulin resistant Wistar rats, and this increase is independent of weight. Objetivo: O objetivo deste estudo foi avaliar a associação entre a resistência à insulina e os níveis de grelina e PYY em jejum em ratos Wistar. Materiais e métodos: Um total de 25 ratos Wistar machos, pesando 200-300 g, foi usado neste estudo. Os animais foram mantidos em gaiolas com um ciclo de luz escuro de 12/12h e alimentados com ração padrão e água ad libitum. Depois de um jejum de 12h, os valores de grelina, PYY, insulina e glicose foram determinad...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - June 17, 2014 Category: Endocrinology Source Type: research
Effect of treatment with sitagliptin on somatosensory-evoked potentials and metabolic control in patients with type 2 diabetes mellitus
Conclusion: The results give a glimpse of the possible use of sitagliptin in the treatment of some neurodegenerative conditions of the peripheral nervous system, in addition to its already established role in glycemic control. Objetivo: Avaliar o efeito da sitagliptina nos potenciais evocados somatossensoriais (PESS) e controle metabólico de pacientes com diabetes melito tipo 2, sem neuropatia diabética. Materiais e métodos: Estudo de intervenção, prospectivo e aberto. Os pacientes com menos de seis meses de diagnóstico foram incluídos. Exames dos PESS e testes laboratoriais em jejum e após a estimulação com ...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - June 17, 2014 Category: Endocrinology Source Type: research
Relation between ultra-sensitive C-reactive protein, diabetes and periodontal disease in patients with and without myocardial infarction
Conclusion: Diabetes had an impact in periodontal disease and us-CRP. In patients with AMI, DM and PD considerably increased the us-CRP. Objetivo: O objetivo deste estudo foi avaliar o impacto do diabetes e da doença periodontal na us-CRP, um marcador inflamatório em pacientes com ou sem infarto agudo do miocárdio (IAM). Sujeitos e métodos: Um estudo caso-controle foi conduzido em 401 sujeitos com idades entre 30 e 75 anos que moravam em Bogotá D.C. (Colômbia). Os pacientes que chegavam ao pronto-socorro do hospital universitário de San Ignacio com IAM foram incluídos no grupo caso. O grupo controle foi definido...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - June 17, 2014 Category: Endocrinology Source Type: research
